 | | Vol. 14.46 – 8 December, 2022 |
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| Using genetic mouse models and ex vivo primary organoid cultures, scientists showed that conditional co-deletion of the LATS1 and LATS2 kinases in mature mammary luminal epithelial cells promoted the development of Krt14 and Sox9-expressing basal-like carcinomas that metastasize over time.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that short-term TGFBR inhibitor treatment of peripubertal ACI inbred and Sprague Dawley outbred rats induced lasting changes and prevented estrogen- and carcinogen-induced mammary tumors, respectively.
[Nature Communications] |
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| Researchers reported that insulin/insulin-like growth factor (IGF) signaling supported breast cancer stem cell self-renewal in an IRS2-phosphatidylinositol 3-kinase-dependent manner that involved the activation and stabilization of MYC.
[Cell Reports] |
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| Scientists demonstrated that the F-box protein FBXL2 was a critical negative regulator of breast cancer stem cell stemness and that downregulation of FBXL2 played a causal role in TNBC drug resistance.
[Oncogene] |
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| Investigators identified RBCK1 as an important regulator of hypoxia-inducing factor (HIF) 1α signaling pathway which is activated in breast cancer tumor cells in hypoxia.
[Cell Death & Disease] |
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| Using TNBC as a model, the authors showed that compared to normal human breast epithelial cells, the TNBC cells, MDA-MB-231 and MDA-MB-468 that harbor constitutively active STAT3 also expressed higher glucose-6-phosphate dehydrogenase, thioredoxin reductase 1, NADPH, and glutathione levels for survival.
[Cell Death & Disease] |
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| Researchers found that checkpoint suppressor 1 had a high abundance in TNBC and its expression was tightly associated with malignant phenotype and poor outcomes of patients.
[Cell Death Discovery] |
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| Scientists investigated the effect of the androgen receptor signaling pathway-related long non-coding RNAs (lncRNAs) on the process of subtype classification and the tumor microenvironment of breast cancer.
[Scientific Reports] |
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| Investigators performed RNA-seq analyses on a combined dataset of 2D and 3D cultures of tumorigenic MCF7 and non-tumorigenic MCF10A.
[Scientific Reports] |
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| Researchers investigated the molecular subtype discordance between the primary tumor and circulating tumor cells (CTCs) in breast cancer patients.
[Scientific Reports] |
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| The authors select relevant genes in breast cancer treatment pathways to evaluate treatment response from a pharmacogenetic perspective and highlight polymorphism frequencies and ethnic and continental representation of breast cancer.
[Pharmacogenomics] |
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| Endomag announced that the Magtrace® lymphatic tracer can now be used for all patients undergoing breast cancer surgery across the US while reducing the reliance on uncertain radioactive tracer availability.
[Endomag (GlobeNewswire, Inc.)] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Nencki Institute of Experimental Biology – Warsaw, Poland |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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