 | | Vol. 15.02 – 19 January, 2023 |
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| Using clinical-practice ultrasound elastography for patients’ lesions and atomic force microscopy for surgical samples, scientists showed that increased matrix stiffness was linked with poor responses to neoadjuvant chemotherapy, worse prognosis, and cancer stem cell enrichment in patients with breast cancer.
[Nature
Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that in vitro studies of human mammary epithelial cells with CRISPR-induced mutations in the MAPK and MAP2K components of the JNK pathway had no change in growth in two-dimensional (2D) culture, but promoted epithelial cell proliferation in three-dimensional (3D) culture.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators identified a YAP1 tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in TNBC.
[Cellular And Molecular Life Sciences] |
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| The authors leveraged the WAP-T syngeneic mammary carcinoma mouse model and developed a strategy combining magnetic-activated cell sorting-based tumor cell enrichment with high-throughput transcriptome analyses.
[International Journal of Cancer] |
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| Given the critical role of cancer stem cells in promoting cancer progression, scientists examined the impact of forkhead box transcription factor 1 (FOXO1) inhibition with AS1842856 on basal-like breast cancer and glioblastoma multiforme cell viability.
[FEBS Open Bio] |
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| Investigators studied the role of miR-335 and -145 on programmed cell death 1 receptor-ligand (PD-L1) suppression in breast cancer.
[Scientific Reports] |
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| Researchers investigated in vitro and in vivo effects of filgrastim on cell migration, invasion, and metastasis. A lentivirus vector of the anti- C-X-C chemokine receptor type 4 (CXCR4) receptor was first used for the CXCR4 knockout.
[Medical Oncology] |
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| PLGA-PTX nanoparticles were assayed in breast cancer cell lines, breast cancer stem cells, and multicellular tumor spheroids analyzing cell cycle, cell uptake, and α-tubulin expression.
[Bioimpacts] |
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| Scientists uncovered a role of CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) in trastuzumab-resistant HER2+ breast cancer. CMTM6 expression was upregulated in trastuzumab-resistant HER2+ breast cancer cells.
[Molecular Cancer] |
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| The authors discuss neurotransmitters in the context of breast cancer as well as the risk factors, pharmaceuticals impacting neurotransmitter pathways, and the opportunity for better-integrated models that encompass exercise, the intestinal microbiome, and other non-pharmacologic considerations.
[Oncogene] |
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| Seven researchers from diverse scientific backgrounds won the Ullman Family Team Science Award for a proposal to investigate novel therapies for TNBC, an aggressive, hard-to-treat form of the disease.
[University of Chicago Medicine] |
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| Minerva Biotechnologies announced that the FDA has approved their Investigational New Drug (IND) application to conduct clinical trials with huMNC2-CAR22, aka MUC1*-CAR-1XX, for the treatment of metastatic breast cancers.
[Minerva Biotechnologies (Business Wire)] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | IRCCS Candiolo Cancer Institute – Turin, Italy |
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| | Pompeu Fabra University – Barcelona, Spain |
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| | Stanford Medicine – Stanford, California, United States |
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