 | | Vol. 15.03 – 26 January, 2023 |
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| Scientists used both the sleeping beauty transposon mutagenesis system and CRISPR-Cas9–mediated genome-wide screening in mice to identify potential genetic alterations that acted synergistically with breast cancer–associated gene 1 deficiency to promote tumorigenesis.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers determined that expression of the pseudokinase nuclear receptor binding protein 1 (NRBP1) was positively associated with poor prognosis in TNBC and was required for efficient migration, invasion, and proliferation of TNBC cells in culture as well as the growth of TNBC orthotopic xenografts.
[Oncogene] |
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| Investigators showed that human lung or mammary cells underwent squamous metaplasia with polyploidization when they were exposed to genotoxic or mitotic drugs.
[Cell Death Discovery] |
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| Using spatial transcriptomics, the authors investigated the abundance and zonation of hepatic genes in cancer-bearing mice. They found that breast cancers affected liver zonation in various distinct manners depending on biological pathways.
[Communications Biology] |
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| Researchers showed that histone lysine demethylase (KDM) 5B-N-terminal truncated, accumulated in breast cancer cell lines due to remarkable protein stability relative to the canonical PLU-1 isoform, which showed a much faster turnover.
[Cancer Gene Therapy] |
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| To delineate catechol-O-methyl transferase (COMT) role in metastasis of estrogen receptor dependent breast cancer, scientists investigated the effect of COMT overexpression on invasion, transcriptome, proteome and interactome of MCF7 cells stably transduced with lentiviral vector carrying COMT gene.
[Scientific Reports] |
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| Investigators found that adriamycin (ADR) + cyperotundone (CYT) inhibited the activity of MCF-7 and MCF-7/ADR cells in breast cancer, as well as causing apoptosis in MCF-7 and MCF-7/ADR cells and blocking the cell cycle in the G0/G1 phase.
[Scientific Reports] |
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| Researchers explored the function of miR-375 in breast cancer. MicroRNA-375 targets were predicted by online target prediction tools and found that HOXA5 was one of the potential targets.
[Applied Biochemistry and Biotechnology] |
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| Scientists established hypoxia-resistant breast cancer cell lines by continuous culture in a hypoxic environment and investigated the effect of eribulin on hormone receptor-positive breast cancer cells that were resistant to endocrine blockade.
[Anticancer Research] |
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| The authors synthesize the existing data on the clinical, pathological and genomic features, management, and outcomes of metaplastic breast cancer. They also identify potential targets for future clinical trials.
[Critical Reviews in Oncology/Hematology] |
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| The team of 41 scientists who made a ground-breaking gene discovery of the BRCA2 cancer gene in 1995, transforming the field of cancer research, have been celebrated with the unveiling of two commemorative plaques in London.
[The Institute of Cancer Research] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | Novartis – Atlanta, Georgia, United States |
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| | Umeå University – Umeå, Sweden |
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| | Imperial College London – London, England, United Kingdom |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | Institute of Cancer Research – London, England, United Kingdom |
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