Mammary Cell News Volume 15.04 | Feb 02 2023

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    Noshin Noorjahan
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    2023-02-02 | MCN 15.04


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.04 – 2 February, 2023
    TOP STORY

    A Palmitate-Rich Metastatic Niche Enables Metastasis Growth via p65 Acetylation Resulting in Pro-Metastatic NF-κB Signaling

    Scientists found that breast cancer cells used palmitate to synthesize acetyl-CoA in a carnitine palmitoyltransferase 1a-dependent manner.
    [Nature Cancer]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Epigenetic Regulation of Neuregulin 1 Promotes Breast Cancer Progression Associated to Hyperglycemia

    Researchers showed that hyperglycemia caused active histone modifications at the Neuregulin 1 enhancer, forming enhanceosome complexes.
    [Nature Communications]

    Full Article

    LncRNA TINCR Impairs the Efficacy of Immunotherapy against Breast Cancer by Recruiting DNMT1 and Downregulating MiR-199a-5p via the STAT1–TINCR-USP20-PD-L1 Axis

    The authors confirmed that tissue differentiation inducing non-protein coding RNA (TINCR) upregulated programmed death-ligand 1 expression in vivo and in vitro, and promoted the progression of breast cancer.
    [Cell Death & Disease]

    Full Article

    METTL3 Regulates Breast Cancer-Associated Alternative Splicing Switches

    Scientists identified a specific alternative splicing (AS) signature associated with breast tumorigenesis in vitro. They characterized the role of methyltransferase-like 3 (METTL3) in modulating breast cancer-associated AS programs.
    [Oncogene]

    Full Article

    Lactate from Glycolysis Regulates Inflammatory Macrophage Polarization in Breast Cancer

    Using multiomics data analysis, investigators found that lactate was mainly derived from glycolysis in breast cancer. Single-cell transcriptome analysis found that breast cancer cells with higher malignancy have higher expression levels of glycolytic metabolic enzymes.
    [Cancer Immunology Immunotherapy]

    Abstract

    Pseudo-Temporal Dynamics of Chemoresistant Triple-Negative Breast Cancer Cells Reveal EGFR/HER2 Inhibition as Synthetic Lethal during Mid-Neoadjuvant Chemotherapy

    To investigate the underlying tumor dynamics in TNBC, the authors performed trajectory analysis on the single-nuclei RNA-seq of chemoresistant tumor clones during neoadjuvant chemotherapy.
    [Iscience]

    AbstractFull ArticleGraphical Abstract

    CENPF Knockdown Inhibits Adriamycin Chemoresistance in Triple-Negative Breast Cancer via the RB-E2F1 Axis

    Researchers found that CENPF, which was highly expressed in TNBC, was associated with a poor prognosis in patients receiving chemotherapy.
    [Scientific Reports]

    Full Article

    S100A9 Promotes Glycolytic Activity in HER2-Positive Breast Cancer to Induce Immunosuppression in the Tumor Microenvironment

    A total of 667 breast cancer patients were enrolled in this study. Haematoxylin and eosin staining were used to count TIN in tissues. Human breast cancer cell lines were transfected with S100A9 specific small interfering RNA.
    [Heliyon]

    Full Article

    Effect of Gubenyiliu Formula II and Its Disassembled Prescriptions on Cell Autophagy in Breast Cancer through PI3K/AKT/mTOR Pathway

    After a breast cancer in situ tumor model was established, mice were randomly distributed into different groups: model, Gubenyiliu II, Quxie, Fuzheng, and tamoxifen groups, and treated correspondingly.
    [Anti-Cancer Drugs]

    Abstract
    Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.
    REVIEWS

    c-MYC Mediates the Crosstalk between Breast Cancer Cells and Tumor Microenvironment

    The authors summarize and review the relevant research clarify that c-MYC is a key mediator between breast cancer cells and tumor microenvironment.
    [Cell Communication and Signaling]

    Full Article

    The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

    Scientists evaluate cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer pathogenesis.
    [Current Nutrition Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    Gilead Awards $7.6 Million in Grants to Advance Health Equity in Breast Cancer

    Gilead Sciences, Inc. awarded $7.6 million in grant funding to 24 US-based, community organizations through the newly created Toward Health Equity Oncology Grant™.
    [Gilead Sciences, Inc.]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2023

    April 14 – 19, 2023
    Orlando, Florida, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Oncogenic Signaling

    Imperial College London – London, England, United Kingdom

    Postdoctoral Fellowship – Breast Cancer

    Umeå University – Umeå, Sweden

    Research Associate – CAR T Immunotherapy

    Imperial College London – London, England, United Kingdom

    Postdoctoral Position – Spatial Omics Analysis

    European Molecular Biology Laboratory – Heidelberg, Germany

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

    > See All Jobs

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