Mammary Cell News Volume 15.06 | Feb 16 2023

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    2023-02-16 | MCN 15.06


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.06 – 16 February, 2023
    TOP STORY

    Targeted MDM2 Degradation Reveals a New Vulnerability for p53 Inactivated Triple Negative Breast Cancer

    Researchers identified an unexpected protein vulnerability in p53-inactivated TNBC and designed a new PROTAC to target it.
    [Cancer Discovery]

    Abstract
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    lncRNA BREA2 Promotes Metastasis by Disrupting the WWP2-Mediated Ubiquitination of Notch1

    Investigators reported that the long noncoding RNA (lncRNA) BREA2 drove breast cancer metastasis by stabilizing the Notch1 intracellular domain.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Polo-Like Kinase 4 (Plk4) Potentiates Anoikis-Resistance of p53KO Mammary Epithelial Cells by Inducing a Hybrid EMT Phenotype

    Scientists investigated the role of Plk4 in carcinogenesis and showed that its overexpression significantly potentiated resistance to cell death by anoikis of nontumorigenic p53 knock-out (p53KO) mammary epithelial cells.
    [Cell Death & Disease]

    Full Article

    DNMT3a-Dermatopontin Axis Suppresses Breast Cancer Malignancy via Inactivating YAP

    Researchers found that DNA methyltransferases (DNMT) 3a-mediated dermatopontin (DPT) promoter hypermethylation resulted in the downregulation of DPT expression in breast cancer and its low expression correlated with poor prognosis.
    [Cell Death & Disease]

    Full Article

    Stabilization of E-Cadherin Adhesions by COX-2/GSK3β Signaling Is a Targetable Pathway in Metastatic Breast Cancer

    The authors discovered that COX-2, a target gene of C/EBPd, or its metabolite prostaglandin E2 promoted protein stability of E-cadherin, β-catenin, and p120 catenin through inhibition of GSK3β.
    [JCI Insight]

    AbstractGraphical Abstract

    Targeting mTOR to Overcome Resistance to Hormone and CDK4/6 Inhibitors in ER-Positive Breast Cancer Models

    Scientists assessed the mechanisms of acquired resistance using T47D and MCF-7 tamoxifen- and palbociclib-resistant cell-line variants in culture and as xenografts, and patient-derived cells obtained from sensitive or resistant patient-derived xenografts.
    [Scientific Reports]

    Full Article

    Epigenetic Alterations Impede Epithelial-Mesenchymal Transition by Modulating Centrosome Amplification and Myc/RAS Axis in Triple Negative Breast Cancer Cells

    Investigators elucidated the effect of epigenetic alterations on centrosome amplification, epithelial-mesenchymal transition, and apoptosis in TNBC adenocarcinoma derived MDA-MB-231 cell line.
    [Scientific Reports]

    Full Article

    Achieving Anticancer Peptides: Protein-Lipid Interactions in Breast Cancer Models

    Researchers explored protein-lipid interactions using lipidomic and mass spectrometry approaches to better understand the molecular determinants of anti-cancer peptide selectivity.
    [Biophysical Journal]

    Abstract

    Determining the Roles of Membrane Tension in Breast Cancer Cell Migration

    The authors developed experimental and analytical approaches that allowed them to monitor polarized membrane trafficking, the formation of adhesive structures, and membrane tension in several migrating breast epithelial cell lines.
    [Biophysical Journal]

    Abstract
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    REVIEWS

    The Oncogenic Roles and Clinical Implications of YAP/TAZ in Breast Cancer

    Scientists give an overview of Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ)-mediated oncogenesis in breast cancer (BC), and then systematically summarize the oncogenic roles of YAP/TAZ in various BC subtypes, BC stem cells, and tumor microenvironments.
    [British Journal of Cancer]

    Full Article

    Immunotherapy in Breast Cancer: An Overview of Current Strategies and Perspectives

    Investigators provide an overview of immunotherapies currently under clinical development and updated key results from clinical trials.
    [npj Breast Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Baylor Receives More than $5.8 Million in CPRIT Funding

    Baylor College of Medicine has been awarded more than $5.8 million in grants by the Cancer Prevention & Research Institute of Texas (CPRIT) to support innovative translational research and cancer treatments.
    [Baylor College of Medicine]

    Press Release

    UPEI Graduate Student Receives Funding for Breast Cancer Research

    Miranda Steeves, a graduate student at the University of Prince Edward Island (UPEI), is working on breast cancer research, with assistance from $11,900 in funding provided by the Canadian Cancer Society’s J.D. Irving, Limited—Excellence in Cancer Research Fund.
    [University of Prince Edward Island]

    Press Release
    FEATURED EVENT

    OrganoidNL Symposium 2023

    March 31, 2023
    Amsterdam, The Netherlands

    > See All Events

    JOB OPPORTUNITIES

    Bioinformatician – Breast Cancer Mutagenesis

    University of Texas Health Science Center – San Antonio, Texas United States

    Team Leader – Breast Cancer Research

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Research Fellow – Hematologic Malignancies and Cancer Biology

    Duke University – Durham, North Carolina, United States

    Program Leader – Basic Science

    Vanderbilt-Ingram Cancer Center – Nashville, Tennessee, United States

    Associate Professor – Department of Cell and Molecular Biology

    University of Mississippi Medical Center – Jackson, Mississippi, United States

    > See All Jobs

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