 | | Vol. 15.09 – 9 March, 2023 |
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| To study underlying cell-cell interactions between dormant disseminated tumor cells and bone lining cells, researchers established a bioinspired dynamic indirect coculture model of estrogen receptor–positive (ER+) breast cancer cells with bone marrow niche cells, human mesenchymal stem cells, and fetal osteoblasts.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators systematically investigated how SMAD-mediated responses were modulated by various ligands of the transforming growth factor β family and compared these ligand responses in quiescent and proliferating MCF10A cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors showed that OBSCN-Antisense RNA 1 (OBSCN-AS1), a novel nuclear long-noncoding RNA gene originating from the minus strand of OBSCN, and OBSCN displayed positively correlated expression and were downregulated in breast cancer biopsies.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers identified transforming acidic coiled-coil containing protein 3 (TACC3) to be overexpressed in tumors with centrosome amplification, and its high expression was associated with dramatically worse clinical outcome.
[Cell Death & Differentiation] |
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| Gene expression profiling identified the liver X receptor (LXR)-dependent transcriptional network as a key pathway that controlled both cancer cell-derived extracellular vesicle-induced migration of B cells and accumulation of B cells in breast cancer tissues.
[Cell Reports] |
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| To understand the role of the normally tumor suppressive myoepithelial cell in disease progression, investigators presented a three-dimensional (3D) in vitro model incorporating both luminal and myoepithelial cells in physiomimetic conditions.
[npj Breast Cancer] |
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| To explore the potential mechanism of Resina Draconis (RD) against breast cancer (BC) using network pharmacology and experimental validation, data on bioactive compounds, potential targets of RD, and related genes of BC were obtained from multiple public databases.
[Scientific Reports] |
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| Methyltransferase like-3 (METTL3) was found to be downregulated in TNBC cells via qPCR and western blot analyses. Co-immunoprecipitation and GST pulldown assays revealed the interaction between acetyl-CoA acetyltransferase 1 (ACAT1) and METTL3.
[Genes And Immunity] |
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| A human cytokine array was performed to investigate the differential expression of cytokines by human epidermal growth factor receptor 2 (HER2) overexpression. qRT- PCR, enzyme-linked immunosorbent assay, and western blot were performed to detect the levels of mRNA and protein expression.
[Anticancer Research] |
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| The effect of isophysalin A on breast cancer stem cells was examined using a mammosphere formation, a colony formation, and a cell migration assay, as well as CD44 analysis, an apoptosis assay, qRT- PCR, western blotting, an electrophoretic mobility shift assay, and a cytokine profiling assay.
[Anticancer Research] |
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| Zoledronic acid and denosumab are bone-modifying agents that have different anticancer activities, and they may be associated with the improvement of survival of breast cancer patients under different mechanisms.
[Journal of Bone and Mineral Metabolism] |
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| The total cost of cancer to the global economy will reach 25.2 trillion international dollars between 2020 and 2050, according to an analysis of 29 cancers across 204 countries.
[Nature] |
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| April 24 – 26, 2023
Hinxton, England, United Kingdom |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Miami – Miami, Florida, United States |
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| | Penn Medicine – Philadelphia, Pennsylvania, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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