 | | Vol. 15.10 – 16 March, 2023 |
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| Using single-cell RNA sequencing analysis of human preneoplastic BRCA1+/mut and noncarrier breast tissues, researchers showed distinct changes in epithelial homeostasis including increased proliferation and expansion of basal-luminal intermediate progenitor cells.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used syngeneic ER+ mouse models in which disseminated tumor cells displayed a dormant phenotype in young mice but accelerated metastatic outgrowth in an aged or fibrotic microenvironment.
[Nature Cancer] |
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| The authors showed that invasive breast cancer cells exposed to hypoxia released small extracellular vesicles that disrupted the differentiation of normal mammary epithelia, expanded stem and luminal progenitor cells, and induced atypical ductal hyperplasia and intraepithelial neoplasia.
[Journal Of Clinical Investigation] |
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| To study the origin and dynamics of the basement membrane (BM), scientists developed and imaged a laminin beta1-Dendra2 mouse model. They showed that the turnover of laminin beta1 was faster in the BMs that surrounded the tumor lobes than in the BMs that surrounded the healthy epithelium.
[Developmental Cell] |
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| Investigators identified X-inactive specific transcript (XIST) as a key regulator of breast cancer stem cells, which exhibited aldehyde dehydrogenase positive epithelial-and CD24loCD44hi mesenchymal-like phenotypes.
[Oncogene] |
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| The clinical significance of mucin 16 (MUC16) and ELAVL1 or Hu antigen R was examined using breast cancer TCGA data. Microarray was performed on MUC16 knockdown and scramble TNBC cells, and MUC16-associated genes were identified using RNA immunoprecipitation and metastatic cDNA array.
[Breast Cancer Research] |
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| In breast cancer cell lines, tumor-expressed FVII drove changes reminiscent of epithelial-to-mesenchymal transition, tumor cell invasion, and expression of the pro-metastatic genes SNAI2 and SOX9.
[Blood Advances] |
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| Co-culture systems in vitro and co-implantation systems in vivo were designed to characterize the interactions between breast cancer stem cells and bulk cancer cells.
[Cell Communication and Signaling] |
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| Researchers showed that overexpression of TRIM47 correlated with progression and poor prognosis in TNBC. They demonstrated that TRIM47 directly interacted with breast cancer susceptibility gene 1 (BRCA1) and induced ubiquitin-ligase-mediated proteasome turnover of BRCA1.
[Oncogenesis] |
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| Scientists evaluated the effect of fluorouracil, a typical chemotherapy for the treatment of TNBC, on cell motility by utilizing a cell line with high αB-crystallin expression.
[Scientific Reports] |
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| Multi-dimensional integration of high-resolution single-cell and spatial technologies has highlighted the importance of the entire breast cancer ecosystem and the presence of distinct cellular “neighborhoods.”
[Cell] |
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| The authors assess the status of research on RET in breast cancer and evaluate the therapeutic potential of RET-selective kinase inhibitors across major breast cancer subtypes.
[Breast Cancer Research] |
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| Agendia, Inc. announced the first patient has been enrolled in the PROOFS Registry trial. The study aims to determine whether premenopausal women with early HR+ breast cancer can avoid chemotherapy, and maintain strong outcomes by opting for temporary ovarian function suppression with endocrine therapy.
[Agendia, Inc.] |
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| May 7 – 10, 2023
Vancouver, British Columbia, Canada |
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| | Columbia University – New York City, New York, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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