 | | Vol. 15.12 – 30 March, 2023 |
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| Researchers reported that apoptotic cancer cells enhanced the metastatic outgrowth of surviving cells through peptidylarginine deiminase 4-mediated nuclear expulsion.
[Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that the long noncoding RNA LITATS1 was an epithelial gatekeeper in normal epithelial cells and inhibited epithelial-mesenchymal transition in breast and non-small cell lung cancer cells. Transcriptome analysis identified LITATS1 as a TGF-β target gene.
[EMBO Journal] |
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| Using tissue-specific mouse models, investigators found that loss of single-minded 2 (Sim2) reduced lactation performance, whereas gain of Sim2s enhanced and extended lactation performance and survival of mammary epithelial cells.
[Cell Death & Differentiation] |
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| Thea authors developed cRGD-modified nanoparticles of a conjugate of doxorubicin, adjudin, and D-α-tocopherol polyethylene glycol 1000 succinate linked with pH-sensitive bonds, and then combined the nanoparticles with PD-L1 antagonist to treat 4T1 TNBC.
[Nanoscale Horizons] |
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| Scientists found that TNBC cells displayed frequent, spontaneous inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ oscillations, which were sensed by mitochondria.
[Frontiers in Cell and Developmental Biology] |
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| Researchers performed various bioinformatic analyses, including machine learning models to identify critical regulatory lncRNAs affecting prognosis in breast cancer. The in situ hybridization assay was carried out to confirm the expression levels of lncRNA PCAT19 in tissue specimens.
[Cancer Medicine] |
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| The authors developed and characterized patient‑derived orthotopic xenografts from patients with endocrine hormone receptor‑positive, HER2‑negative metastatic breast cancer who had relapsed on therapy.
[Oncology Reports] |
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| The cytotoxicity of crocin was evaluated by CCK-8 assay. Cell proliferation was assessed using EdU incorporation assay and western blot analysis. Breast cancer-related genes were extracted from GEPIA.
[Environmental Toxicology] |
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| Immunohistochemistry was adopted to analyze the protein level of 6-phosphofructose-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3) in benign breast tissues, invasive ductal carcinoma with diabetes, and invasive ductal carcinoma without diabetes.
[World Journal of Surgical Oncology] |
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| The authors ponder the biomedical significance of various curcumin (Cur)-nanomedicines and adaptable functionalizations for amplifying the physicochemical properties and anticancer efficacy of Cur while reversing the multidrug resistance and reoccurrence in breast cancer.
[Journal of Nanobiotechnology] |
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| Scientists illustrate the altered metabolism in breast cancer and its underlying mechanisms, as well as metabolic interventions in breast cancer treatment, with the intention to provide strategies for developing novel therapeutic treatments for breast cancer.
[Molecular Diagnosis & Therapy] |
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| Merck announced that the US FDA has granted full approval to KEYTRUDA for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options.
[Merck] |
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| May 7 – 10, 2023
Vancouver, British Columbia, Canada |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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