Mammary Cell News Volume 15.13 | April 06 2023

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    Noshin Noorjahan
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    2023-04-06 | MCN 15.13


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.13 – 6 April, 2023
    TOP STORY

    Loss of the Receptors ER, PR, and HER2 Promotes USP15-Dependent Stabilization of PARP1 in Triple-Negative Breast Cancer

    Scientists demonstrated that the deubiquitinase USP15 interacted with and deubiquitinated poly(ADP-ribose) polymerase 1 (PARP1) to promote its stability, thereby stimulating DNA repair, genomic stability, and TNBC cell proliferation.
    [Nature Cancer]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    CircPVT1 Promotes ER-Positive Breast Tumorigenesis and Drug Resistance by Targeting ESR1 and MAVS

    Investigators reported that circPVT1, a circular RNA generated from the lncRNA PVT1, was highly expressed in estrogen receptor (ER)α-positive breast cancer cell lines and tumor samples and was functionally important in promoting ERα-positive breast tumorigenesis and endocrine therapy resistance.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Cryptochrome 2 Acetylation Attenuates Its Antiproliferative Effect in Breast Cancer

    The authors elucidated the post-translational regulations of cryptochrome 2 (Cry2) and its role in breast cancer pathogenesis. They identified p300-drived acetylation as a novel Cry2 post-translational modification, which histone deacetylase 6 could reverse.
    [Cell Death & Disease]

    Full Article

    Let-7b-5p Inhibits Breast Cancer Cell Growth and Metastasis via Repression of Hexokinase 2-Mediated Aerobic Glycolysis

    Scientists showed that microRNA-let-7b-5p (let-7b-5p) repressed HK2 expression by targeting its 3′-untranslated region. By suppressing HK2-mediated aerobic glycolysis, let-7b-5p restrained breast tumor growth and metastasis both in vitro and in vivo.
    [Cell Death Discovery]

    Full Article

    Targeting the NF-κB Pathway Enhances Responsiveness of Mammary Tumors to JAK Inhibitors

    Researchers demonstrated that exposure of macrophages to janus kinase (JAK) inhibitors led to activation of NF-κB signaling, which resulted in increased expression of genes known to be associated with therapeutic resistance.
    [Scientific Reports]

    Full Article

    Pyrazole Derivatives of Pyridine and Naphthyridine as Proapoptotic Agents in Cervical and Breast Cancer Cells

    In search of novel compounds with pro-apoptotic potential, pyrazolo-pyridine and pyrazolo-naphthyridine derivatives were investigated against cervical cancer and breast cancer cells. The anti-proliferative activity was determined through the MTT assay.
    [Scientific Reports]

    Full Article

    POP1 Promotes the Progression of Breast Cancer through Maintaining Telomere Integrity

    Investigators identified that processing of precursor 1 (POP1) was upregulated in breast cancer cell lines and tissues and patients with higher POP1 expression were associated with poor outcomes.
    [Carcinogenesis]

    AbstractGraphical Abstract

    Antitumor Effect of a Novel Humanized MUC1 Antibody-Drug Conjugate on Triple-Negative Breast Cancer

    Researchers developed a novel humanized antibody that specifically bound MUC1 expressed in breast cancer cells and conjugated a humanized MUC1 (HzMUC1) antibody to monomethyl auristatin (MMAE). HzMUC1-MMAE showed an anti-proliferative effect on HER2 positive trastuzumab-resistant breast cancer.
    [Heliyon]

    Full Article

    Bisphenol A Prevents MCF-7 Breast Cell Apoptosis via the Inhibition of Progesterone Receptor Transactivation

    Scientists investigated the effects of bisphenol A on P4 signaling and TRIM22 and TP53 expression in human breast carcinoma MCF-7 cells. In MCF-7 cells incubated with various concentrations of P4, TRIM22 messenger RNA (mRNA) levels increased in a dose-dependent manner.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Glucose-Conjugated Glutenin Nanoparticles for Selective Targeting and Delivery of Camptothecin into Breast Cancer Cells

    Glucose-conjugated camptothecin-loaded glutenin nanoparticles were fabricated to deliver camptothecin to MCF-7 cells via GLUT-1 transporter protein.
    [Naunyn-Schmiedebergs Archives Of Pharmacology]

    AbstractGraphical Abstract
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    REVIEWS

    Proteolysis Targeting Chimera (PROTAC) as a Promising Novel Therapeutic Modality for the Treatment of Triple-Negative Breast Cancer (TNBC)

    The authors give a brief overview of TNBC and PROTACs and highlight the rationale behind using PROTACs as a therapeutic modality in patients with TNBC.
    [Drug Development Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Western Research Projects Receive over $9 Million in Federal Grants

    The Canadian Institutes of Health Research awarded $9.4 million in federal funding to 17 Western researchers for their innovations in medical and health studies.
    [Western University]

    Press Release
    FEATURED EVENT

    Diversity in a Dish: Pluripotent Stem Cells in Genetic Analysis and Disease Modeling

    May 23 – 25, 2023
    Bar Harbor, Maine, United States & Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Breast Cancer Research

    Columbia University Irving Medical Center – New York City, New York, United States

    Post Doctoral Training Fellow – Homologous Recombination Defective Cancers

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Training Fellow – Cell Death & Immunity

    Institute of Cancer Research – London, England, United Kingdom

    Staff Scientist – Molecular and Cellular Mechanisms of Breast Cancer Initiation

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Fellow – Medical Oncology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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