Mammary Cell News Volume 15.14 | April 13 2023

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    2023-04-13 | MCN 15.14


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.14 – 13 April, 2023
    TOP STORY

    N-acetylcysteine Overcomes NF1 Loss-Driven Resistance to PI3Kα Inhibition in Breast Cancer

    Depletion of NF1 in PIK3CAH1047R breast cancer cell lines and a patient-derived organoid model showed that NF1 loss reduced sensitivity to phosphatidylinositol 3-kinase α (PI3Kα) inhibition and correlated with enhanced glycolysis and lower levels of reactive oxygen species.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
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    ER-Localized JmjC Domain-Containing Protein JMJD8 Targets STING to Promote Immune Evasion and Tumor Growth in Breast Cancer

    Researchers demonstrated that an endoplasmic reticulum (ER)-localized JmjC domain-containing protein, JMJD8, inhibited STING-induced type I interferon responses to promote immune evasion and breast tumorigenesis.
    [Developmental Cell]

    AbstractGraphical Abstract

    eIF2Bδ Blocks the Integrated Stress Response and Maintains eIF2B Activity and Cancer Metastasis by Overexpression in Breast Cancer Stem Cells

    The authors described a unique translation regulatory axis enacted by reduced expression of miR-183 in breast cancer stem cells, which they showed targeted the eIF2Bδ subunit of guanine nucleotide exchange factor eIF2B.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    ETV7 Reduces Inflammatory Responses in Breast Cancer Cells by Repressing the TNFR1/NF-κB Axis

    Scientists identified TNFRSF1A, encoding for the main receptor of TNF-α, TNFR1, as one of the genes down-regulated by ETV7. They showed that ETV7 directly bound to the intron I of this gene, and that the ETV7-mediated down-regulation of TNFRSF1A reduced the activation of NF-κB signaling.
    [Cell Death & Disease]

    Full Article

    RON-Augmented Cholesterol Biosynthesis in Breast Cancer Metastatic Progression and Recurrence

    Investigators modeled breast cancer recurrence using implantation of RON-overexpressing murine breast cancer cells. Recurrent growth was examined after tumor resection via in vivo imaging and ex vivo culture of circulating tumor cells from whole blood samples from tumor bearing mice.
    [Oncogene]

    Abstract

    Suppression of Triple-Negative Breast Cancer Aggressiveness by LGALS3BP via Inhibition of the TNF-α–TAK1–MMP9 Axis

    The authors investigated the function and underlying mechanism of action of lectin galactoside-binding soluble 3 binding protein (LGALS3BP) in TNBC progression and determined the therapeutic potential of nanoparticle-mediated delivery of LGALS3BP in TNBC.
    [Cell Death Discovery]

    Full Article

    PDK1-Stabilized LncRNA SPRY4-IT1 Promotes Breast Cancer Progression via Activating NF-κB Signaling Pathway

    Researchers found that lncRNA sprouty4-intron transcript 1 (SPRY4-IT1) was regulated by pyruvate dehydrogenase kinase 1 (PDK1) with correlation analysis, and PDK1 upregulated SPRY4-IT1 remarkably in breast cancer cells.
    [Molecular Carcinogenesis]

    Abstract

    Circular Forms of Dedicator of Cytokinesis 1 Promotes Breast Cancer Progression by Derepressing Never in Mitosis Related Kinase 2 via Sponging miR-128-3p

    Scientists explored the regulation between circular forms of dedicator of cytokinesis 1 and miR-128-3p, and its implication on the pathogenesis of breast cancer modulated by never in mitosis related kinase 2.
    [Environmental Toxicology]

    Abstract

    The Estrogen/miR-338-3p/ADAM17 Axis Enhances the Viability of Breast Cancer Cells via Suppressing NK Cell’s Function

    miR-338-3p level was found to be significantly downregulated in breast cancer (BC) tissues and estrogen receptor positive (ER+) cells, this difference was more obvious in ER+ patients or BC patients at advanced stage.
    [Environmental Toxicology]

    Abstract
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    REVIEWS

    Triumphs and Challenges in Exploiting poly(ADP-Ribose) Polymerase Inhibition to Combat Triple-Negative Breast Cancer

    The authors discuss the roles of poly(ADP-ribose) polymerase (PARP) in mediating DNA repair processes in breast epithelial cells, mechanisms of PARPi resistance in TNBC, and recent advances in the development of agents designed to overcome PARPi resistance in TNBC.
    [Journal of Cellular Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    METUPUK Are Delighted by the Scottish Medicines Consortium (SMC) Acceptance of Enhertu (Trastuzumab Deruxtecan) for Routine Use on the NHS

    The SMC has accepted Enhertu for treating HER2-positive unresectable or metastatic breast cancer in adults who have received one or more prior anti-HER2 based therapies for routine use on the NHS in Scotland.
    [METUPUK]

    Press Release
    FEATURED EVENT

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    May 27 – 28, 2023
    West Dover, Vermont, United States

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Head and Neck Cancer

    University of Liverpool – Liverpool, England, United Kingdom

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Research Scientist – Breast Cancer Research

    Columbia University Irving Medical Center – New York City, New York, United States

    Staff Scientist – Molecular and Cellular Mechanisms of Breast Cancer Initiation

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship – Breast Cancer

    Harvard Medical School – Boston, Massachusetts, United States

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