 | | Vol. 15.15 – 20 April, 2023 |
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| To discover alternative treatments to transcriptionally active ESR1 gene fusions (ESR1-TAF), a mass spectrometry-based kinase inhibitor pulldown assay was deployed to identify druggable kinases that were upregulated by diverse ESR1-TAFs.
[Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To identify oncogenic RNA-binding proteins in TNBC, researchers employed an in vivo CRISPR screen and a TNBC progression model, which revealed small nuclear ribonucleoprotein polypeptide C (SNRPC) as a key modulator of TNBC progression.
[Cancer Research] |
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| Scientists investigated the biological role and clinical applications of proline rich 15 (PRR15) on TNBC. PRR15 gene was differentially expressed between TNBC and non-TNBC patients, previously described as an oncogenic factor in breast cancer.
[Cell Death & Disease] |
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| Investigators examined in vitro reciprocal effect between breast cancer cells and cancer-sensitized peripheral primary sensory neurons. Secretome obtained from either cultured DRG neurons from tumor-burdened rats, or MRMT1 breast cancer cells were used to study neuronal and cancer cell reciprocity.
[International Journal of Cancer] |
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| Researchers showed that CD146 negatively regulated transendothelial migration in breast cancer. This inhibitory activity was reflected by a reduction in melanoma cell adhesion molecule (MCAM) gene expression and increased promoter methylation in tumor tissue compared to normal breast tissue.
[Frontiers in Cell and Developmental Biology] |
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| The authors investigated whether withaferin A (WA) inhibited breast cancer induction of osteoclast differentiation. At plasma achievable doses, WA treatment inhibited osteoclast differentiation induced by three different subtypes of breast cancer cells.
[Molecular Carcinogenesis] |
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| Investigators obtained pre-treatment biopsy and post-treatment mastectomy specimens from a retrospective cohort of TNBC patients treated with neoadjuvant chemotherapy.
[Scientific Reports] |
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| Scientists studied the effect that 16.4 µm fragment type polypropylene microplastics, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer.
[Scientific Reports] |
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| Three breast cancer cell lines were treated with a combination of 1 μM tamoxifen and 10 μM of a cholesterol depleting agent following transfection with a miR-128 inhibitor or a miR-223 mimic.
[Iubmb Life] |
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| Mass spectrometry analysis of miRNA-overexpressed cell lines MCF7-miR526b, MCF7-miR655, and miRNA-low MCF7-Mock cell-free secretomes identified 34 differentially expressed proteins coded by eight genes.
[Heliyon] |
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| The authors review recent studies that have yielded insights into important regulators of lineage integrity and mechanisms that trigger mammary epithelial lineage derail, and evaluate their impacts on breast tumor development.
[Trends in Cell Biology] |
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| The Cancer Prevention and Research Institute of Texas has granted $1.05 million to The University of Texas at San Antonio (UTSA) for cancer research.
[The University of Texas at San Antonio] |
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| May 28 – 31, 2023
Killarney, Ireland |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Columbia University Irving Medical Center – New York City, New York, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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