Mammary Cell News Volume 15.16 | April 27 2023

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    2023-04-27 | MCN 15.16


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.16 – 27 April, 2023
    TOP STORY

    TMEM25 Inhibits Monomeric EGFR-Mediated STAT3 Activation in Basal State to Suppress Triple-Negative Breast Cancer Progression

    Researchers reported that epidermal growth factor receptor (EGFR) monomer might activate signal transducer activator of transcription-3 (STAT3) in the absence of transmembrane protein transmembrane (TMEM) 25, whose expression was frequently decreased in human TNBC.
    [Nature Communications]

    Full Article
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    CHST2-Mediated Sulfation of MECA79 Antigens Is Critical for Breast Cancer Cell Migration and Metastasis

    Scientists reported that identification of a gene encoding the key GlcNAc sulfation enzyme CHST2 was induced by Snail in multiple breast cancer cells.
    [Cell Death & Disease]

    Full Article

    Methionine Alleviates Heat Stress-Induced Ferroptosis in Bovine Mammary Epithelial Cells through the Nrf2 Pathway

    Investigators evaluated the regulatory effect and mechanism of methionine in alleviating heat stress-induced ferroptosis by using bovine mammary epithelial cell line as an in vitro model.
    [Ecotoxicology And Environmental Safety]

    Full Article

    Never in Mitosis Gene A-Related Kinase-8 Promotes Proliferation, Migration, Invasion, and Stemness of Breast Cancer Cells via β-Catenin Signaling Activation

    To investigate the role of never in mitosis gene A-related kinase-8 (NEK8) in breast cancer, NEK8 was knocked down in MDA-MB-231, BT549, and HCC38 breast cancer cell lines.
    [Scientific Reports]

    Full Article

    Prolactin-Induced Protein (PIP) Increases the Sensitivity of Breast Cancer Cells to Drug-Induced Apoptosis

    Scientists analyzed the impact of PIP expression on resistance of breast cancer (BC) cells to anti-cancer drugs and its biological role in BC progression. Expression of PIP and apoptotic genes in BC cell lines was analyzed using real-time PCR and Western blotting.
    [Scientific Reports]

    Full Article

    SNRPD1 Conveys Prognostic Value on Breast Cancer Survival and Is Required for Anthracycline Sensitivity

    Researchers conducted in silico analysis at gene expression and genetic levels to differentiate the clinical relevance of SNRPD1 and SNRPE, and explored their differential functionalities and molecular mechanistic associations with cancer in vitro.
    [BMC Cancer]

    Full Article

    Altered Expression of Anti-Apoptotic Protein Api5 Affects Breast Tumorigenesis

    The authors carried out in silico analyses using TCGA and GENT2 datasets to understand expression pattern of apoptosis inhibitor 5 (Api5) in breast cancer patients followed by investigating the protein expression in Indian breast cancer patient samples.
    [BMC Cancer]

    Full Article

    Lithium Chloride Promotes Endogenous Synthesis of CLA in Bovine Mammary Epithelial Cells

    Scientists investigated whether lithium chloride could encourage conjugated linoleic acid (CLA) synthesis in mammary epithelial cells.
    [Biological Trace Element Research]

    Abstract

    Long Noncoding RNA HOTAIR Promotes Breast Cancer Development through the lncRNA HOTAIR/miR-1/GOLPH3 Axis

    Researchers investigated the level of HOTAIR in breast cancer and its clinical pathological characteristics by bioinformatic methods. They evaluated the effects of HOTAIR and miRNA-1 expression on the biological behavior of breast cancer cells by experiments including qPCR and Cell Counting Kit-8 assay.
    [Clinical And Translational Oncology]

    Abstract

    Comparison of Transcriptome Alterations Induced by Pendimethalin or Its Commercial Formulation Stomp Aqua in Human MCF-7, MCF-10 A, and MCF-12 a Mammary Epithelial Cells

    Investigators mined high-throughput data from the US National Toxicology Program to identify whether pendimethalin possessed an estrogenic capability in human cells.
    [BMC Research Notes]

    Full Article
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    REVIEWS

    Bone Serves as a Transfer Station for Secondary Dissemination of Breast Cancer

    The authors summarize the clinical and experimental evidence that bone is a transfer station for the secondary dissemination of breast cancer.
    [Bone Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    Damon Runyon Cancer Research Foundation Awards Quantitative Biology Fellowships to Three Cutting-Edge Scientists

    Damon Runyon has announced its 2023 Quantitative Biology Fellows, three exceptional early-career scientists who are applying the tools of computational science to generate and interpret cancer research data at extraordinary scale and resolution.
    [Damon Runyon Cancer Research Foundation]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Breast Cancer

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Tumor Biology

    University of Gothenburg – Gothenburg, Sweden

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Research Scientist – Breast Cancer Research

    Columbia University Irving Medical Center – New York City, New York, United States

    Postdoctoral Training Fellow – Cell Death & Immunity

    Institute of Cancer Research – London, England, United Kingdom

    > See All Jobs

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