Mammary Cell News Volume 15.17 | May 04 2023

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    2023-05-04 | MCN 15.17


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.17 – 4 May, 2023
    TOP STORY

    Combination of Novel Oncolytic Herpesvirus with Paclitaxel as an Efficient Strategy for Breast Cancer Therapy

    The antitumor effect of VG161 and paclitaxel was confirmed in a breast cancer xenograft mouse model.
    [Journal of Medical Virology]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Inhibition of VEGF Binding to Neuropilin-2 Enhances Chemosensitivity and Inhibits Metastasis in Triple-Negative Breast Cancer

    Using TNBC as a model, researchers demonstrated that aNRP2-10 could be used to isolate cancer stem cells (CSCs) from heterogeneous tumor populations and inhibit CSC function and epithelial-to-mesenchymal transition.
    [Science Translational Medicine]

    Abstract

    Dependency of NELF-E-SLUG-KAT2B Epigenetic Axis in Breast Cancer Carcinogenesis

    Using cancer cell lines and patient-derived tumor organoids, scientists demonstrated that loss of the negative elongation factor (NELF) complex inhibited breast cancer development through downregulating epithelial-mesenchymal transition and stemness-associated genes.
    [Nature Communications]

    Full Article

    Macrophages Maintain Mammary Stem Cell Activity and Mammary Homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 Axis

    Investigators showed that mammary resident macrophages regulated mammary epithelium cell division and mammary development through TNF-α-Cdk1/Cyclin B1 axis.
    [npj Regenerative Medicine]

    Full Article

    A Junction-Dependent Mechanism Drives Murine Mammary Cell Intercalation for Ductal Elongation

    The authors developed a quantitative cell culture assay that modeled intercalation into epithelial monolayers. They found that tight junction proteins played a key role in this process.
    [Developmental Cell]

    AbstractGraphical Abstract

    Inhibition of ACAA1 Restrains Proliferation and Potentiates the Response to CDK4/6 Inhibitors in Triple-Negative Breast Cancer

    Researchers identified that acetyl-CoA acyltransferase 1 (ACAA1) was highly expressed in the luminal androgen receptor (LAR) subtype of TNBC compared with adjacent normal tissues in their TNBC proteomics dataset.
    [Cancer Research]

    Abstract

    Noncanonical Role of Singleminded-2s in Mitochondrial Respiratory Chain Formation in Breast Cancer

    Scientists showed that the breast tumor suppressor gene Singleminded-2 (SIM2) promoted mitochondrial oxidative phosphorylation using breast cancer cell line models.
    [Experimental & Molecular Medicine]

    Full Article

    Sulforaphane Prevents LPS-Induced Inflammation by Regulating the Nrf2-Mediated Autophagy Pathway in Goat Mammary Epithelial Cells and a Mouse Model of Mastitis

    Investigators explored the anti-oxidant and anti-inflammatory effects and potential molecular mechanisms of sulforaphane in lipopolysaccharide-induced primary goat mammary epithelial cells and a mouse model of mastitis.
    [Journal Of Animal Science And Biotechnology]

    Full Article

    Haloarchaeal Carotenoids Exert an In Vitro Antiproliferative Effect on Human Breast Cancer Cell Lines

    Researchers evaluated the in vitro cytotoxic effect of Haloferax mediterranei bacterioruberin-rich carotenoid extracts in six breast cancer cell lines, representative of the intrinsic phenotypes and a healthy mammary epithelium cell line.
    [Scientific Reports]

    Full Article

    Circ_0001387 Regulates SKA2 to Accelerate Breast Cancer Progression through miR-136-5p

    Circ_0001387, miR-136-5p, and spindle and kinetochore-associated protein 2 (SKA2) levels were analyzed by quantitative real-time polymerase chain reaction.
    [Thoracic Cancer]

    Full Article

    The Effects of MYC on Exosomes Derived from Cancer Cells in the Context of Breast Cancer

    Scientists investigated for the first time how MYC affected the biological functions of normal breast cells cocultured with exosomes derived from MYC-expression manipulated breast cancer cells.
    [Chemical Biology & Drug Design]

    Abstract
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    REVIEWS

    Exploring the Anti-Cancer Potential of Dietary Phytochemicals for the Patients with Breast Cancer: A Comprehensive Review

    Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti-cancer therapies, have prompted scientists to discover innovative approaches and new chemo-preventive agents.
    [Cancer Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    NHS Grampian Breast Cancer Research Team Win Prestigious National Award

    NHS Grampian’s breast cancer research team is to receive the National Institute for Health Research’s CREST Award. The accolade recognizes the surgical team that has made the greatest contribution to clinical trials research across the UK during the last year.
    [NHS Grampian]

    Press Release
    FEATURED EVENT

    ATC 2023

    June 3 – 7, 2023
    San Diego, California, United States
    JOB OPPORTUNITIES

    Postdoctoral Positions – Cancer 3D Genome

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Research Assistant – Cancer Biology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Research Assistant – Lipidomic Dependencies of Cancer

    Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    Postdoctoral Research Fellow – Breast Cancer

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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