 | | Vol. 15.18 – 11 May, 2023 |
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| Researchers discovered thousands of long noncoding RNAs expressed in human mammary epithelial cells and analyzed their expression in individual cells of the normal breast.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that Kita-Kyushu lung cancer antigen-1 (KK-LC-1) determined the stemness of TNBC aldehyde dehydrogenase (ALDH)+ cells via binding with FAT1 and subsequently promoting its ubiquitination and degradation.
[Nature Communications] |
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| The authors reported the development of a rationally designed antibody drug conjugate for the treatment of late-stage and refractory TNBC.
[Science Advances] |
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| Researchers used lentiviral barcoding coupled to single-cell RNA sequencing to trace clonal and transcriptional evolution during breast cancer metastasis.
[Cancer Research] |
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| Investigators examined the role of Kruppel Like Factor 12 (KLF12) in breast cancer and its associated molecular mechanisms. KLF12 was found to promote the proliferation of breast cancer and inhibit apoptosis in response to genotoxic stress.
[Cell Death & Disease] |
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| Vangl1 and Vangl2 knockdown and overexpression and Wnt5a stimulation were employed to manipulate Wnt/planar cell polarity signaling in a battery of breast cancer cell lines representing all breast cancer subtypes, and in tumor organoids from MMTV-PyMT mice.
[Breast Cancer Research] |
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| Scientists characterized the impact of overweight and obesity on tissue markers of risk, using normal breast biopsies, a mouse model of diet-induced obesity, and cultured breast acini.
[npj Breast Cancer] |
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| Investigators demonstrated that the splicing factor SRSF2 caused the inclusion of exon-8b, leading to the formation of the anti-angiogenic vascular endothelial growth factor A (VEGFA)-165b isoform under normoxic conditions.
[iScience] |
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| Researchers investigated the anticancer activity of synthetic diphenyl disulfide in breast cancer cell lines.
[Environmental Toxicology] |
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| Scientists discovered that phosphorylation of mitogen-activated protein kinase 1 was regulated by tamoxifen as well as estrogen related receptor alpha (ERRα).
[PLOS One] |
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| The authors gather some results for fused-pyrimidine derivatives on various cancerous cell lines and animal evaluation to highlight their potency.
[Journal Of Biomolecular Structure & Dynamics] |
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| Women at average risk for breast cancer should get screening mammograms every other year starting at age 40, according to a proposed guideline update from the US Preventive Services Task Force, reflecting improved diagnostic technology and treatment.
[CTV News] |
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| June 4 – 7, 2023
Heidelberg, Germany |
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| | Karolinska Institute – Stockholm, Sweden |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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Mammary Cell News
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