 | | Vol. 15.19 – 18 May, 2023 |
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| The authors showed that focal amplifications in breast cancer frequently derived from a mechanism, which they termed translocation–bridge amplification, involving inter-chromosomal translocations that lead to dicentric chromosome bridge formation and breakage.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified one antisense RNA that drove cancer progression by upregulating the redox enzyme NADPH quinone dehydrogenase 1 (NQO1), and named it NQO1-AS.
[Nature Cancer] |
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| Integrative transcriptomic and preclinical studies unraveled that p140Cap controlled an epistatic axis where, through the upstream inhibition of β-Catenin, it restricted tumorigenicity and self-renewal of tumor-initiating cells.
[Nature Communications] |
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| With a genome-wide CRISPR-Cas9 knockout screen, scientists identified previously unknown biomarkers and potential therapeutic targets of endocrine resistance.
[Science Advances] |
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| Researchers identified that acetyl-CoA acyltransferase 1 (ACAA1) was highly expressed in the luminal androgen receptor subtype of TNBC compared with adjacent normal tissues in their TNBC proteomics dataset.
[Cancer Research] |
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| Investigators reported a prodrug, Nic-A that was designed to target TNBC cancer stem cells (CSCs) and was found to inhibit both proliferating TNBC cells and CSCs via signal transducer and transcriptional activator 3 dysregulation and suppression of CSC-like properties.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists comprehensively evaluated the cellular effects of N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate in a panel of human breast cancer cell lines and normal breast cells.
[Cell Death Discovery] |
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| Using bioinformatics analysis, the authors identified four hub prognostic genes related to CD8+ T-lymphocyte infiltration and found that chromatin-modifying protein 4A (CHMP4A) was the most significant gene.
[Cancer Science] |
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| Researchers evaluated the effect of the combination of chloroquine and propranolol on colorectal cancer and TNBC by using as in vitro models the colorectal cancer cell lines HCT116, HT29, and CT26, and as TNBC models the 4T1, M-406, and MDA-MB-231 cell lines.
[Scientific Reports] |
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| Investigators treated SK-BR-3 cells with Herceptin and the signal transducer and activator of transcription 3 (STAT3)-inhibitor, FLLL32, and assessed the apoptosis and expression of apoptosis-related proteins, VEGF, Her-2, and apoptosis targets of STAT3.
[Scandinavian Journal of Immunology] |
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| The authors present a systematic overview of biogenesis and down streaming molecular mechanism of the subgroups of non-coding RNAs (ncRNAs). They also explain ncRNA-based strategies and challenges to target the chemo-, radio-, and immunoresistance in TNBCs from a clinical standpoint.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| Next&Bio Inc. has signed a memorandum of understanding (MOU) with the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore on the establishment of collaboration to realize the development of novel precision medicine therapeutics using cancer-organoids.
[Next&Bio Inc. (Business Wire)] |
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| June 18 – 22, 2023
Keystone, Colorado, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Karolinska Institute – Stockholm, Sweden |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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