 | | Vol. 12.20 – 25 May, 2023 |
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| Investigators identified a mechanism mediated by sialyltransferases that induced an acidic tumor permissive microenvironment in BRCA1-mutant and most BRCA1-low breast cancers.
[Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The effects and molecular mechanisms of chronic unpredictable mild stress on modulating tumor-associated macrophages (TAMs) and pre-metastatic niche formation were clarified by experiments including multiplex immunofluorescence technique, cytokine array, and chromatin immunoprecipitation.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists found that receptor interacting protein kinase 1 (RIPK1)-dependent necroptosis promoted vasculogenic mimicry (VM) formation in TNBC. Knockdown of RIPK1 significantly suppressed the number of necroptotic cells and VM formation.
[Cell Death & Disease] |
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| Researchers reported that ZNF133, a zinc-finger protein, was negatively associated with poor survival and advanced pathological staging of breast carcinomas. Moreover, ZNF133 was a transcription repressor physically associated with the KAP1 complex.
[Oncogene] |
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| Investigators used chemical biology tools to track how a metabolite of glucose, GlcNAc, became linked to the transcriptional regulatory protein tet-methylcytosine dioxygenase 1 as an O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification in three TNBC cell lines.
[Cancer Cell International] |
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| Expression of bone morphogenetic protein (BMP), BMP receptors, and antagonists in breast cancer were analyzed by using TCGA-BRCA and E-MTAB-6703 cohorts.
[Frontiers In Oncology] |
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| To understand the mechanisms of p-Ser134-GR action in the presence of glucocorticoid receptor (GR) agonists, the authors examined glucocorticoid-driven transcriptomes in CRISPR knock-in models of TNBC cells expressing wild-type or phospho-mutant GR.
[Endocrinology] |
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| Scientists showed that Adenosine Deaminase Acting on RNA 1 (ADAR1) was more abundantly expressed in infiltrating breast cancer (BC) tumors than in benign tumors. Further, ADAR1 protein expression was higher in aggressive BC cells.
[Scientific Reports] |
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| Researchers investigated the molecular mechanism of miR-183 in breast cancer. Phosphatase and tensin homolog (PTEN) was validated by dual luciferase assay as a target gene of miR-183. Through qRT-PCR analysis, miR-183 and PTEN mRNA levels in breast cancer cell lines were measured.
[Scientific Reports] |
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| Scientists investigated the putative role of zinc finger protein 726 (ZNF726) in breast cancer tumorigenic potency. Gene expression analysis using multifactorial cancer databases predicted overexpression of ZNF726 in various cancers, including breast cancer.
[Journal of Cellular Biochemistry] |
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| The authors describe the mechanism of different peptides in reversing breast cancer resistance, including promoting cancer cell apoptosis and non-apoptotic regulatory cell death of cancer cells.
[Frontiers In Pharmacology] |
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| Rayyanah Barnawi is one of two Saudis on Axiom Space’s second private mission. During her scheduled 10 days in orbit on the International Space Station, the 34-year-old biomedical scientist plans to carry out stem cell and breast cancer research.
[BBC] |
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| June 25 – 30, 2023
Newry, Maine, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | University of Galway – Galway, Ireland |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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