 | | Vol. 15.21 – 1 June, 2023 |
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| Through a whole-genome CRISPR activation screen, followed by mechanistic investigation, researchers identified phospholipid-modifying enzymes MBOAT1 and MBOAT2 as ferroptosis suppressors.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using breast cancer cell lines, scientists showed that reduction of aldehyde dehydrogenase 1 family member 2 (ALDH1L2) expression increased ROS levels and the production of both formate and formyl-methionine.
[Cell Reports] |
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| The authors isolated epithelial and mesenchymal populations from human breast cancer metastatic biopsies and assessed their functional potential in vivo. Progressively decreasing epithelial cell adhesion molecule levels correlated with declining disease propagation.
[Cell Reports] |
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| Investigators showed that RB-loss and high E2F1/E2F2 signatures correlated with expression of poliovirus receptor (PVR), CD274 and other immune-checkpoint modulators and that pRB repressed whereas RB depletion and E2F1 induced PVR and CD274 in TNBC cells.
[Oncogenesis] |
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| Researchers determined the correlation between miR-561-3p and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and their roles in breast cancer progression.
[Scientific Reports] |
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| The authors examined the expression and prognostic significance of cannabinoid receptor 2 in breast cancer tissues by qPCR, second-generation sequencing, western blot, and immunohistochemistry.
[Cancer Medicine] |
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| Investigators focused on the regulatory function of the lncRNA DSCR9 in breast cancer stem cells (BCSCs). Through bioinformatics analysis, DSCR9, microRNA-504-5p, and G protein-coupled receptor 65 were identified as targets implicated in breast cancer development.
[Human Cell] |
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| The antiproliferative effects of Calotropis procera were investigated on two cancer cell lines: human colon, HCT-116, and breast, MCF-7, cancer. The effectiveness of the plant extract on the cytotoxicity, apoptosis, cell cycle progression, and protein expression profiles of HCT-116 and MCF-7 cells was analyzed.
[Heliyon] |
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| In order to better understand the phenolic compounds found in Isabella grapes and the biological effect they induce on breast cancer cells, an ultrasound-assisted extraction was carried out.
[Heliyon] |
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| CD4- and CD25-positive cells were sorted from cultured T lymphocytes of a previously characterized experimental thymic tumor model composed of thymic nurse cells and abundant lymphoid stroma.
[Thoracic Cancer] |
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| An ambuic acid derivative anticancer compound was isolated from Talaromyces flavus, and its cytotoxicity and apoptosis induction potential were analyzed.
[Chemical Biology & Drug Design] |
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| Scientists summarize the vital druggable targets, therapeutic approaches, and strategies associated with TNBC.
[Molecular and Cellular Biochemistry] |
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| The authors elucidate the mechanism of current targeting strategies and the engineering methods to construct nanocarrier targeting systems or to improve their targeting efficiency.
[Journal of Applied Polymer Science] |
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| A post-doctoral researcher at Queen’s University Cancer Research Institute has been recognized nationally for her groundbreaking work to monitor breast cancer using a simple, routine blood test.
[Queen’s University] |
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| Researchers from Rensselaer Polytechnic Institute (RPI) and Albany Medical College were awarded a $3.3 million grant over five years by the National Cancer Institute to use artificial intelligence to improve targeted drug therapy in HER2-positive breast cancer treatment.
[Albany Medical College] |
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| June 26 – 29, 2023
Boston, Massachusetts, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | Salk Institute – La Jolla, California, United States |
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| | University of Galway – Galway, Ireland |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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