Mammary Cell News Volume 15.23 | June 15 2023

    By
    Noshin Noorjahan
    -
    0
    26








    2023-06-15 | MCN 15.23


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.23 – 15 June, 2023
    TOP STORY

    Inhibition of USP7 Induces p53-Independent Tumor Growth Suppression in Triple-Negative Breast Cancers by Destabilizing FOXM1

    Investigators found that the oncoprotein Forkhead Box M1 (FOXM1) acted as a potential driver for tumor growth in TNBC and through a proteomic screen, they identified USP7 as a major regulator of FOXM1 in TNBC cells.
    [Cell Death & Differentiation]

    Abstract
    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Self-Assembly of Organelle-Localized Neuropeptides Triggers Intrinsic Apoptosis against Breast Cancer

    Scientists developed an enzyme responsive precursor based on the neuropeptide Y1 receptor ligand, which self-assembled into nanoscale assemblies in the lysosomes and subsequently had an appreciable destructive effect on the mitochondria and cytoskeleton, resulting in breast cancer cell apoptosis.
    [Advanced Healthcare Materials]

    Abstract

    Breast Cancer Cell Mesenchymal Transition and Metastasis Directed by DAP5/eIF3d-Mediated Selective mRNA Translation

    Using genome-wide transcriptomic and translatomic studies, an alternate mechanism of cap-dependent mRNA translation by the DAP5/eIF3d complex was shown to be essential for metastasis, epithelial-to-mesenchymal transition, and tumor directed angiogenesis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer

    Researchers profiled EZH2 and NF-κB factor co-localization and positive gene regulation genome-wide, and defined a subset of NF-κB targets and genes associated with oncogenic functions in TNBC that was enriched in patient datasets.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Fibroblast Growth Factor 3 Promotes Spontaneous Mammary Tumorigenesis in Tientsin Albino 2 Mice via the FGF3/FGFR1/STAT3 Pathway

    To elucidate the molecular mechanism of mouse mammary tumor virus (MMTV), which led to the development of spontaneous breast cancer (SBC) in Tientsin albino 2 (TA2) mice, the integration site of MMTV in TA2 SBC was identified using whole-genome sequencing.
    [Frontiers In Oncology]

    Abstract

    The Protein and miRNA Profile of Plasma Extracellular Vesicles (EVs) Can Distinguish Feline Mammary Adenocarcinoma Patients from Healthy Feline Controls

    The authors investigated whether miRNAs associated with feline mammary adenocarcinoma tumors were secreted in extracellular vesicles (EVs) and whether they could potentially be used as a cancer biomarker in EVs from feline plasma.
    [Scientific Reports]

    Full Article

    Tamoxifen Decreases Ovarian Toxicity without Compromising Cancer Treatment in a Rat Model of Mammary Cancer

    Scientists examined mechanisms of the protective action of tamoxifen in the ovaries of tumor-bearing rats treated with the chemotherapy drug cyclophosphamide.
    [BMC Genomics]

    Full ArticleGraphical Abstract

    Exosome-Derived ANXA9 Functions as an Oncogene in Breast Cancer

    Using online bioinformatics tools, researchers predicted annexin A-9 (ANXA9) expression and its correlation with the clinicopathological characteristics of breast cancer (BCA) patients. RT-qPCR and western blot were utilized to measure ANXA9 mRNA and ANXA9 protein expression in BCA patient tissues and cells.
    [Journal Of Pathology Clinical Research]

    Full Article

    Exosomal GPT2 Derived from Triple-Negative Breast Cancer Cells Promotes Metastasis by Activating BTRC

    BT549 and BT474 cells were cultured and their exosomes were isolated by using ultracentrifugation. Cells migrated through the membrane were stained with crystal violet, and then were observed by microscope.
    [Thoracic Cancer]

    Full Article

    Circ_0059457 Promotes Proliferation, Metastasis, Sphere Formation, and Glycolysis in Breast Cancer Cells by Sponging miR-140-3p to Regulate UBE2C

    The expression of circ_0059457, taspase 1, microRNA-140-3p, and ubiquitin-binding enzyme E2C (UBE2C) was detected by quantitative real-time PCR.
    [Biochemical Genetics]

    Abstract
    Register for a recorded organoid panel discussion moderated by Dr. James Wells
    REVIEWS

    The Ubiquitin–Proteasome System in Breast Cancer

    Ubiquitin–proteasome system is a selective proteolytic system that is associated with the expression or function of target proteins and participates in various physiological and pathological processes of breast cancer.
    [Trends in Molecular Medicine]

    Abstract

    ACSL4: Biomarker, Mediator, and Target in Quadruple Negative Breast Cancer

    The author suggests three expanded roles for ACSL4: a biomarker for the classification of breast cancer subtypes; a predictor of sensitivity to hormone-based and certain other therapies; and a target for the development of new treatment modalities.
    [Oncotarget]

    Full Article
    INDUSTRY AND POLICY NEWS

    HighField Biopharmaceuticals Receives US FDA IND Clearance for Phase I Trial of Immunoliposome HF158K1 for Treatment of HER2 Low and HER2+ Cancers

    The company will conduct a Phase I multi-regional, open-label, clinical trial in patients who have advanced refractory solid tumors with HER2 low and HER2+ expression. HER2-expressing solid tumors include breast, bladder, pancreatic, ovarian, stomach, colon, prostate, lung, uterus, and cervix cancers.
    [HighField Biopharmaceuticals ]

    Press Release
    FEATURED EVENT

    89th Harden Conference – Proteoglycans: Matrix Master Regulators 2023

    September 4 – 7, 2023
    Surrey, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Breast Pathologist – Pathology

    University of Vermont – Burlington, Vermont, United States

    Higher Scientific Officer – Proteomics

    Institute of Cancer Research – London, England, United Kingdom

    Research Associate – Bioinformatics

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Immuno-Oncology Research

    Salk Institute – La Jolla, California, United States

    Postdoctoral Researcher – Comparative Breast Cancer Program

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mammary Cell News Twitter