 | | Vol. 15.24 – 22 June, 2023 |
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| In validation studies, genetic disruption of calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) expression or inhibition of its activity with small molecule inhibitors disrupted spontaneous metastatic outgrowth from primary tumors in murine xenograft models of TNBC.
[Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Nanodiamonds were tested and optimized to deliver miR-34a. The physical-chemical properties of nanodiamonds were investigated suggesting electrical stability and uniformity of structure and size.
[Molecular Therapy – Nucleic Acids] |
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| Scientists demonstrated that the expression of ZNF451, a poorly characterized vertebrate zinc-finger protein, was upregulated in TNBC and associated with a poor prognosis.
[Cell Reports] |
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| Using genome-wide transcriptomic and translatomic studies, an alternate mechanism of cap-dependent mRNA translation by the DAP5/eIF3d complex was shown to be essential for metastasis, epithelial-to-mesenchymal transition, and tumor directed angiogenesis.
[Cell Reports] |
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| Researchers identified an unannotated nuclear long noncoding RNA that they designated LETS1 that was not only increased but also perpetuated by TGF-β signaling.
[Science Signaling] |
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| Immunohistochemical studies of tissue microarray revealed increased activation of non-receptor tyrosine kinase, ACK1 in most of the breast cancer subtypes, independent of their hormone receptor status.
[Oncogene] |
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| The authors investigated the molecular mechanism through which ERα/LKB1 complex might modulate the expression of E-cadherin, influencing tumor growth, progression, and distant metastasis.
[International Journal Of Cancer] |
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| Multiomics analysis of chromatin immunoprecipitation sequencing and RNA sequencing were performed in cell lines derived from endometrial cancer and mammary tumor to screen the differential co-regulatory factors of progesterone receptor.
[Cell Death Discovery] |
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| Scientists identified a deubiquitinase, ubiquitin-specific peptidase 9, X-linked (USP9X), that could physically interact with and deubiquitinate K48-linked ubiquitinated cell division cycle 123 (CDC123) at the K308 site.
[Molecular Carcinogenesis] |
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| Alcohol consumption is associated with an increased risk of breast cancer, even at low alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol intake is low.
[Journal of Applied Toxicology] |
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| Three researchers from Cornell University and University of Rochester are getting a boost in funding from the Breast Cancer Coalition in Rochester. Among these grant awards include a $50,000 Breast Cancer Research Faculty Grant and two $25,000 Pre-Doctoral Student Grants.
[Nexstar Media Inc.] |
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| Breast Cancer Canada announced a new research grant in collaboration with AstraZeneca Canada and Illumina. Breast Cancer Canada also announced the recipients of its annual Precision Oncology Research Grants.
[Breast Cancer Canada (Business Wire)] |
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| University of Tennessee Health Science Center researchers Wei Li, PhD and Tiffany Seagroves, PhD, are principal investigators on a $3.07 million grant from the National Cancer Institute for a project to develop a new series of drugs targeting microtubules to stop the spread of breast cancer to the brain and bone.
[The University of Tennessee Health Science Center] |
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| September 20 – 23, 2023
Milan, Italy |
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| | University of Galway – Galway, Ireland |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | University of Vermont – Burlington, Vermont, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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