Mammary Cell News Volume 15.26 | July 06 2023

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    Noshin Noorjahan
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    2023-07-06 | MCN 15.26


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.26 – 6 July, 2023
    TOP STORY

    Cell Facilitation Promotes Growth and Survival Under Drug Pressure in Breast Cancer

    Scientists studied interactions between estrogen receptor-positive breast cancer cell lineages that were sensitive and resistant to ribociclib-induced cyclin-dependent kinase 4 and 6 inhibition.
    [Nature Communications]

    Full Article
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Stanniocalcin 1 Promotes Lung Metastasis of Breast Cancer by Enhancing EGFR–ERK–S100A4 Signaling

    Researchers reported that tumor-secreted stanniocalcin 1 promoted the pulmonary metastasis of breast cancer by enhancing the invasiveness of tumor cells and promoting angiogenesis and lung fibroblast activation in the metastatic microenvironment.
    [Cell Death & Disease]

    Full Article

    GATA Zinc Finger Protein p66β Promotes Breast Cancer Cell Migration by Acting as a Co-Activator of Snail

    Investigators reported that Snail cooperated with GATA zinc finger protein p66β to transactivate genes in breast cancer cells.
    [Cell Death & Disease]

    Full Article

    Lysine Metabolism Is a Novel Metabolic Tumor Suppressor Pathway in Breast Cancer

    Scientists created a new model to better understand how the obese microenvironment alters nuclear receptor function in breast cancer. The obesity related cancer phenotype was PPARγ dependent.
    [Oncogene]

    Abstract

    Truncated SCRIB Isoform Promotes Breast Cancer Metastasis through HNRNP A1 Mediated Exon 16 Skipping

    The authors investigated the function of SCRIB isoforms in breast cancer metastasis and their regulatory mechanisms.
    [Acta Pharmacologica Sinica]

    Abstract

    SERPINA3-ANKRD11-HDAC3 Pathway Induced Aromatase Inhibitor Resistance in Breast Cancer Can Be Reversed by HDAC3 Inhibition

    To identify the genes pivotal for endocrine-resistance progression, researchers screened five datasets and found seven commonly dysregulated genes in endocrine-resistant breast cancer cells.
    [Communications Biology]

    Full Article

    PAX5-miR-142 Feedback Loop Promotes Breast Cancer Proliferation by Regulating DNMT1 and ZEB1

    Investigators identified paired box protein 5 (PAX5) as the upstream regulator of miR-142-5p/3p through ALGGEN website and verified by series of assays in vitro and in vivo.
    [Molecular Medicine]

    Full Article

    NNAT Is a Novel Mediator of Oxidative Stress That Suppresses ER + Breast Cancer

    To evaluate the role of neuronatin (NNAT) on [Ca2+]i homeostasis, scientists used a combination of bioinformatics, gene expression and promoter activity assays, CRISPR gene manipulation, and more.
    [Molecular Medicine]

    Full Article

    Synergistic Anti-Tumor Effect of Toosendanin and Paclitaxel on Triple-Negative Breast Cancer via Regulating ADORA2A-EMT Related Signaling

    Researchers evaluated whether toosendanin could enhance the efficacy of paclitaxel, a common chemotherapeutic agent, against TNBC.
    [Advanced Biology]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Chromatin Organization and Transcriptional Programming of Breast Cancer Cell Identity

    The authors explore the current state of understanding of chromatin architecture in breast cancer subtypes and its potential role in defining their phenotypic characteristics.
    [Endocrinology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Biden Promised a ‘War on Cancer’ — But Declared War on the Cure Instead

    The Biden administration has adopted a series of policies that attack critical steps needed to bring new treatments out of the lab and to the patients who need them.
    [STAT]

    Editorial
    FEATURED EVENT

    AFLAS Congress 2023

    September 13 – 15, 2023
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    JOB OPPORTUNITIES

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    NCI Center for Cancer Research – Bethesda, Maryland, United States

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    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellowship – Cancer Research

    Ume̴ University РUme̴, Sweden

    Higher Scientific Officer – Proteomics

    Institute of Cancer Research – London, England, United Kingdom

    Breast Pathologist – Pathology

    University of Vermont – Burlington, Vermont, United States

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