Mammary Cell News Volume 15.27 | July 13 2023

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    2023-07-13 | MCN 15.27


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.27 – 13 July, 2023
    TOP STORY

    A Novel Polypeptide CAPG-171aa Encoded by circCAPG Plays a Critical Role in Triple-Negative Breast Cancer

    CircRNA expression data in TNBC were reanalyzed and then circCAPG was selected for further study. To identify the polypeptide-coding function of circCAPG, a series of experiments, such as mass spectrometry and dual-luciferase reporter assays were conducted.
    [Molecular Cancer]

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    Dysfunction of Ubiquitin Protein Ligase MYCBP2 Leads to Cell Resilience in Human Breast Cancers

    Researchers performed a comprehensive functional multi-omics analysis of somatic mutations in breast cancer and identified previously unknown key regulators of breast cancer tumorgenicity.
    [NAR Cancer]

    Full ArticleGraphical Abstract

    Molecular Profiling of Aromatase Inhibitor Sensitive and Resistant ER+HER2- Postmenopausal Breast Cancers

    Given the limited understanding of intrinsic resistance in estrogen receptor positive (ER+) breast cancer (BC) tumors, scientists conducted a large-scale molecular analysis to identify features that impacted the response of ER + HER2- BC to aromatase inhibitors.
    [Nature Communications]

    Full Article

    A PDA-Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy

    Polydopamine (PDA)-modified decellularized lung scaffolds were designed which could serve as a functional biosystem to study tumor progression and anticancer drug screening, as well as mimic the tumor microenvironment.
    [Advanced Science]

    Full Article

    Acquired Secondary HER2 Mutations Enhance HER2/MAPK Signaling and Promote Resistance to HER2 Kinase Inhibition in Breast Cancer

    Investigators showed that secondary acquired HER2T862A and HER2L755S mutations promoted resistance to HER2 tyrosine kinase inhibitors via enhanced HER2 activation and impaired neratinib binding.
    [Cancer Research]

    Abstract

    Embedded Bioprinting of Breast Tumor Cells and Organoids Using Low Concentration Collagen Based Bioinks

    Scientists produced embedded, bioprinted breast cancer cells and tumor organoid models using low concentration collagen I based bioinks.
    [Advanced Healthcare Materials]

    Abstract

    Sumoylated SnoN Interacts with HDAC1 and p300/CBP to Regulate EMT-Associated Phenotypes in Mammary Organoids

    Investigators found that sumoylation promoted the interaction of SnoN with the epigenetic regulators histone deacetylase 1 (HDAC1) and histone acetylase p300 in epithelial cells.
    [Cell Death & Disease]

    Full Article

    Extracellular Vesicle-Associated Tyrosine Kinase-Like Orphan Receptors ROR1 and ROR2 Promote Breast Cancer Progression

    Extracellular vesicles were isolated by differential ultracentrifugation from cell culture supernatant as well as plasma samples from healthy individuals and breast cancer patients.
    [Cell Communication and Signaling]

    Full Article

    The ELK3-DRP1 Axis Determines the Chemosensitivity of Triple-Negative Breast Cancer Cells to CDDP by Regulating Mitochondrial Dynamics

    Scientists demonstrated that ELK3, an oncogenic transcriptional repressor that is highly expressed in TNBC, determined the chemosensitivity of two representative TNBC cell lines to cisplatin by regulating mitochondrial dynamics.
    [Cell Death Discovery]

    Full Article

    CMA Mediates Resistance in Breast Cancer Models

    A cohort of patients and breast cancer cells have been screened for doxorubicin effect and chaperone-Mediated Autophagy (CMA) activation by analysing the lysosome associated membrane protein 2A level.
    [Cancer Cell International]

    Full Article

    Simultaneous Isolation of Hormone Receptor Positive Breast Cancer Organoids and Fibroblasts Reveals Stroma-Mediated Resistance Mechanisms

    The authors presented an optimized protocol that allowed high take-rate, and simultaneous propagation of patient-derived organoids and matching cancer-associated fibroblasts, from primary and metastatic hormone receptor-positive breast cancers.
    [Journal Of Biological Chemistry]

    Full Article

    Codelivery of Resveratrol Melatonin Utilizing pH Responsive Sericin Based Nanocarriers Inhibits the Proliferation of Breast Cancer Cell Line at the Different pH

    Investigators developed a surface charge reversal sericin-based nanocarrier to co-deliver resveratrol and melatonin to MCF-7 breast cancer cells as combination therapy.
    [Scientific Reports]

    Full Article

    Predictive Biological Factors for Late Survival in Patients with HER2-Positive Breast Cancer

    Scientists determined predictive factors for late survival in patients with human epidermal growth factor receptor-2 (HER2)-positive breast cancer. They analyzed 20,672 patients with HER2-positive stage I–III breast cancer.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Regulatory miRNAs, circRNAs, and lncRNAs in Cell Cycle Progression of Breast Cancer

    The authors summarize the latest related literature in breast cancer that emphasize the regulatory roles of miRNAs, circRNAs, and lncRNAs in the cell cycle progress of breast cancer.
    [Functional & Integrative Genomics]

    Abstract
    INDUSTRY AND POLICY NEWS

    Novartis Retreats from TIGIT, Handing $300M Candidate Back to BeiGene

    Having paid $300 million to enter the TIGIT space by acquiring ociperlimab in 2021, Novartis is now handing the candidate back to BeiGene.
    [Fierce Biotech]

    News Article
    FEATURED EVENT

    2023 Cellular and Molecular Mechanisms of Toxicity Conference GRC

    August 13 – 18, 2023
    Andover, New Hampshire, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Cancer Drug Persistence & Tumor Microenvironment

    Albert Einstein College of Medicine – New York City, New York, United States

    Scientific Director – Clinical Research

    NCI Center for Cancer Research – Bethesda, Maryland, United States

    Postdoctoral Fellowship – Cancer Research

    Umeå University – Umeå, Sweden

    Higher Scientific Officer – Proteomics

    Institute of Cancer Research – London, England, United Kingdom

    Breast Pathologist – Pathology

    University of Vermont – Burlington, Vermont, United States

    > See All Jobs

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