 | | Vol. 15.28 – 20 July, 2023 |
| |
|
|
| Scientists found that upregulation of dolichyl-phosphate N-acetylglucosaminyltransferase (DPAGT1) sustained high-level HER2 shedding to confer trastuzumab resistance, which was associated with poor clinical outcomes.
[Journal Of Clinical Investigation] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators reported gene-centric common insertion-sites (gCIS) that were enriched in primary-tumors, in metastases, or shared by both compartments.
[Nature Communications] |
|
|
|
| The authors found that receptor activator of nuclear factor-κB (RANK) overexpression in luminal breast cancer was associated with intrinsic resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, both in vitro and in mouse xenografts.
[Cell Reports Medicine] |
|
|
|
| Researchers identified insulin-like growth factor–binding protein 2 (IGFBP2) as a potent adipocrine factor secreted by healthy breast adipocytes that acted as a barrier against invasive progression.
[Science Advances] |
|
|
|
| Using two independent cohorts of breast cancer patients, investigators identified nuclear PRMT5 expression as an independent predictive marker of sensitivity to tamoxifen.
[EMBO Molecular Medicine] |
|
|
|
| Scientists identified the long non-coding RNA (lncRNA) actin gamma 1 pseudogene 25 (AGPG) as a regulator of E2F1 activity in endocrine resistant breast cancer. Expression of AGPG was increased in endocrine-resistant breast cancer cells, which was driven by epigenomic activation of an enhancer.
[Cancer Research] |
|
|
|
| Investigators demonstrated that ectopic high FOXA1 (H-FOXA1) expression promoted estrogen receptor-positive (ER+) breast cancer metastasis in a xenograft mouse model.
[Cell Reports] |
|
|
|
| Researchers demonstrated that receptor for advanced glycation end products (RAGE) signaling maintained the mesenchymal phenotype of aggressive TNBC cells by enforcing the expression of SNAIL1.
[Oncogene] |
|
|
|
| Transcriptomic analysis of primary xenograft tumor and metastatic tissue revealed high concordance in gene and protein changes with both drugs, with TTP488 showing greater potency against metastatic driver pathways.
[npj Breast Cancer] |
|
|
|
| Scientists explored the functional role of loss of miR-6844 in breast cancer cells derived mammosphere. Down expression of miR-6844 significantly decreased cell proliferation in MCF-7 and T47D cells derived mammosphere in a time-dependent manner.
[Journal of Cellular Biochemistry] |
|
|
|
| Researchers investigated the functional roles and target genes of miR-4796 and miR-1287 in breast cancer cells in response to radiation.
[Breast Cancer] |
|
|
|
|
| The authors provide an updated narrative review focusing on the impact of tibolone on breast. They report data from major preclinical and clinical studies regarding the effects of the use of this compound on breast tissue and breast density.
[Reproductive Sciences] |
|
|
|
|
| Professor Nicholas Turner, Professor of Molecular Oncology at The Institute of Cancer Research, London, and Head of the Ralph Lauren Centre for Breast Cancer Research, has received the Translational Research Award by the European Society for Medical Oncology (ESMO).
[The Institute of Cancer Research] |
|
|
|
|
| October 2 – 4, 2023
Boston, Massachusetts, United States |
|
|
|
|
|
| | City of Hope – Duarte, California, United States |
|
|
|
| | Albert Einstein College of Medicine – New York City, New York, United States |
|
|
|
| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
|
|
|
| | Ume̴ University РUme̴, Sweden |
|
|
|
| | Institute of Cancer Research – London, England, United Kingdom |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
