 | | Vol. 15.30 – 3 August, 2023 |
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| RNA sequencing analyses of the claudin-low TNBC cells untreated or treated with panobinostat were performed to identify the differentially expressed genes.
[npj Precision Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In vitro and in vivo experiments confirmed that the circRNA-SFMBT2 level was positively correlated with the estrogen receptor (ER) α protein level, implying a regulatory role for circRNA-SFMBT2 in ERα signaling.
[Cell Death & Disease] |
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| Using TNBC cell models, researchers demonstrated that mitogen-activated protein kinase 4 (MAPK4) could also enhance phosphoinositide-dependent protein kinase-1 (PDK1) protein synthesis, thus phosphorylate/activate PDK1 substrates beyond AKT.
[PLOS Biology] |
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| By comparing the gene expression patterns in cancer-associated fibroblasts (CAFs) and normal fibroblasts, scientists found SPRY2 expression was significantly decreased in CAFs and decreased SPRY2 expression was correlated with worse prognosis in breast cancer patients.
[Breast Cancer Research] |
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| Investigators showed that promyelocytic leukemia protein (PML) knockdown in MDA-MB-231, but not MCF7, breast cancer cells, prolonged stem-cell-like survival, and increased cell proliferation and migration, which was in line with gene-enrichment results from their RNA sequencing analysis.
[Molecular Oncology] |
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| Breast cancer-related RNA-Seq data were obtained from the TCGA database to analyze the correlation between discoidin domain receptor 1 (DDR1) and immune cells.
[Molecular Medicine] |
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| An antisolvent precipitation method was used to fabricate the nanocrystals and optimize them using central composite design.
[Nanomedicine] |
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| Researchers performed bioinformatics analysis to analyze the differentially expressed genes between normal breast tissues and TNBC tissues, and comprehensive network pharmacology analyses.
[Scientific Reports] |
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| The adhesion and encapsulation efficiency of low-cost carboxylate-modified fluorescent nanoparticles by breast cancer cells with high and low metastatic potential had been evaluated; benign cells were used as control.
[Scientific Reports] |
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| Qualitative and quantitative analysis of nanoparticle cellular uptake and accumulation was conducted using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy.
[Nanotechnology] |
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| Scientists talk about the crosstalk between Hippo and Wnt signaling pathways and the potential microRNAs that might regulate the interplay between the two pathways in breast cancer, which has not been explored earlier.
[Life Sciences] |
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| The authors summarize two different functions of PGRMC1: (i) to predict the prognosis of breast cancer (BC) patients and (ii) being a possible predictive marker for BC risk during hormone replacement therapy as suggested from in vitro and animal research.
[Breast Care] |
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| Susan G. Komen® announced the fourth metastatic breast cancer-focused research grant supported through the Komen Metastatic Breast Cancer Collaborative Research Initiative.
[Susan G. Komen] |
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| Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
[Science Insider] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | NICHD – Bethesda, Maryland, United States |
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| | Albert Einstein College of Medicine – New York City, New York, United States |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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