Mammary Cell News Volume 15.32 | Aug 17 2023

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    2023-08-17 | MCN 15.32


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.32 – 17 August, 2023
    TOP STORY

    Coagulation Factor FVIIa Enhances PD-L1 Expression and Its Stability in Breast Cancer Cells to Promote Breast Cancer Immune Evasion

    The authors investigated whether coagulation factor FVIIa could protect breast cancer cells from CD8 T cell-mediated killing.
    [Journal Of Thrombosis And Haemostasis]

    Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    Triple-Negative Breast Tumors Are Dependent on Mutant p53 for Growth and Survival

    Scientists developed an autochthonous somatic K14-Cre driven TNBC mouse model with p53R172H and p53R245W mutations in which mutant p53 can be toggled on and off genetically while leaving the tumor microenvironment intact and wild-type for p53.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Identification of a Novel PAK1/HDAC6 Dual Inhibitor ZMF-23 That Triggers Tubulin-Stathmin Regulated Cell Death in Triple Negative Breast Cancer

    Researchers discovered a novel dual-targeting PAK1/HDAC6 inhibitor which presented profound inhibitory activity against PAK1 and HDAC6 and robust antiproliferative potency in MDA-MB-231 cells.
    [International Journal of Biological Macromolecules]

    Abstract

    Nanoparticles Carrying Paclitaxel and Anti-miR-221 for Breast Cancer Therapy Triggered by Ultrasound

    In order to improve the chemotherapeutic effect in TNBC, investigators developed a novel kind of nanoparticles shelled with PLGA and loaded with perfluoropentane, paclitaxel, and anti-miR-221 inhibitor.
    [Cell Death Discovery]

    Full Article

    Estrogen-Related Receptor Alpha (ERRα) Promotes Cancer Stem Cell-Like Characteristics in Breast Cancer

    The authors evaluated the role of ERRα in the maintenance of breast cancer stem cells using breast cancer cell lines.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    DAB2IP Suppresses Invadopodia Formation through Destabilizing ALK by Interacting with USP10 in Breast Cancer

    Researchers found that DOC-2/DAB2 interacting protein (DAB2IP) effectively suppressed invadopodia formation and metastasis in breast cancer, both in vitro and in vivo.
    [iScience]

    AbstractFull Article

    Resistance to Hormone Therapy in Breast Cancer Cells Promotes Autophagy and EGFR Signaling Pathway

    Scientists developed MCF-7 cell lines resistant to Fulvestrant and Tamoxifen, with the aim of investigating mechanisms underlying resistance to hormonoe therapy in breast cancer.
    [American Journal Of Physiology-Cell Physiology]

    Abstract

    Short Term Exposure to Ethanol Induces Transcriptional Changes in Non-Tumorigenic Breast Cells

    Researchers investigated induced transcriptional changes in response to a short cellular exposure to moderate levels of alcohol.
    [FEBS Open Bio]

    Abstract

    Role of Apoptosis and Autophagy in Folic Acid-Induced Cytotoxicity of Human Breast Cancer Cells In Vitro

    Scientists determined how folic acid affected the apoptotic and autophagic pathways of the breast cancer cell lines MCF-7 and MDA-MB-231.
    [Fundamental & Clinical Pharmacology]

    Abstract
    How to prioritize and manage your research projects
    REVIEWS

    PYK2, a Hub of Signaling Networks in Breast Cancer Progression

    The authors describe unique roles of the non-receptor tyrosine kinase PYK2 in signaling integration and feedback looping in breast cancer.
    [Trends In Cell Biology]

    Abstract

    MicroRNAs Mediated Interaction of Tumor Microenvironment Cells with Breast Cancer Cells during Bone Metastasis

    Scientists summarize the recent developments on the functional role of miRNAs secreted directly or indirectly from the tumor microenvironment-resident cells in facilitating tumor growth, progression, and metastasis.
    [Breast Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    BriaCell Awarded National Cancer Institute Grant to Advance Its Bria-Otsâ„¢ Immunotherapy for Cancer

    BriaCell Therapeutics Corp. announced that the National Cancer Institute has awarded the Company a research grant to advance its platform of personalized off-the-shelf immunotherapies for cancer.
    [BrioCell Therapeutics Corp.]

    Press Release
    FEATURED EVENT

    ESMO Congress 2023

    October 20 – 24, 2023
    Madrid, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Investigator Position – Translational Research

    NICHD – Bethesda, Maryland, United States

    > See All Jobs

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