Mammary Cell News Volume 15.33 | Aug 24 2023

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    2023-08-24 | MCN 15.33


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.33 – 24 August, 2023
    TOP STORY

    Osteoclast-Derived Apoptotic Bodies Inhibit Naive CD8+ T Cell Activation via Siglec15, Promoting Breast Cancer Secondary Metastasis

    Researchers discovered that apoptotic body-null MRL/lpr mice showed resistance to breast cancer cell implantation, with more CD8+ T cell infiltrations and a higher survival rate.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Expression of NORAD Correlates with Breast Cancer Aggressiveness and Protects Breast Cancer Cells from Chemotherapy

    Investigators confirmed upregulated NORAD expression levels in a set of human epithelial breast cancer cell lines, which belong to the most aggressive subtypes
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    FGF1 Supports Glycolytic Metabolism through the Estrogen Receptor in Endocrine-Resistant and Obesity-Associated Breast Cancer

    Scientists explored the effects of fibroblast growth factor 1 (FGF1) on estrogen receptor (ER)-positive endocrine-sensitive and resistant breast cancer and compared that to the effects of the canonical ER ligand, estradiol.
    [Breast Cancer Research]

    Full Article

    An Autophagy-Inducing Stapled Peptide Induces Mitochondria Dysfunction and Triggers Autotic Cell Death in Triple-Negative Breast Cancer

    Researchers showed that one lead peptide Tat-SP4 induced mild increase of autophagy in TNBC cells but showed potent anti-proliferative effect that could not be rescued by inhibitors of programmed cell death pathways.
    [Cell Death Discovery]

    Full Article

    Metabolic Characterization of Transglutaminase 2 Inhibitor Effects in Breast Cancer Cell Lines

    The authors used 1H-NMR metabolomics to study the effects of AA9, a novel TG2 inhibitor, on two breast cancer cell lines with distinct phenotypes, MCF-7 and MDA-MB-231.
    [FEBS Journal]

    Abstract

    Acid Ground Nano-Realgar Processed Product Inhibits Breast Cancer by Inducing Mitophagy via the p53/BNIP3/NIX Pathway

    Investigators verified whether acid ground nano-realgar processed product induced breast cancer mitophagy and explored the mitophagy-mediated mechanism.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    The Oncogene Musashi1 Encodes Novel miRNAs in Breast Cancer

    Scientists reported two novel miRNAs within intron 4 of Musashi1, MSI1, gene named MSM2 and MSM3, which were selected among several miRNA precursors predicted by bioinformatic studies.
    [Scientific Reports]

    Full Article

    LncRNA Miat Knockdown Enhances Pirarubicin-Mediated Anticancer Sensitivity in Breast Cancer Cells

    Researchers investigated the role and mechanism of LncRNA Miat knockdown in improving pirarubicin (THP) sensitivity. They assessed the role of Miat overexpression/knockdown on THP-mediated 4T1 anticancer activity
    [Environmental Toxicology]

    Abstract

    Effects of Photobiomodulation by Low-Power Lasers and LEDs On the Viability, Migration, and Invasion of Breast Cancer Cells

    The authors investigated the effects of exposure to low-power lasers and LEDs on cell viability, migration, and invasion in human breast cancer cells.
    [Lasers in Medical Science]

    Abstract
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    REVIEWS

    Long Non-Coding RNAs as the Critical Regulators of PI3K/AKT, TGF-β, and MAPK Signaling Pathways during Breast Tumor Progression

    Scientists discuss the role of lncRNAs in regulation of PI3K/AKT, MAPK, and TGF-β signaling pathways in breast tumor cells.
    [Journal of Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    As Part of President Biden’s Unity Agenda, Biden Cancer Moonshot Announces Launch of ARPA-H’s CUREIT Project Led by Emory University to Develop New Tools to Strengthen the Immune System and Save Lives

    The Biden Cancer Moonshot is announcing the launch of “Curing the Uncurable via RNA-Encoded Immunogene Tuning” (CUREIT), a project that aims to develop generalizable mRNA platforms that can be harnessed to train the immune system to more effectively fight cancer and other diseases.
    [The White House]

    Press Release
    FEATURED EVENT

    BioCon Asia 2023 – Advanced Cell & Gene Therapy (ACGT) Conference

    October 12 – 13, 2023
    Singapore & Virtual

    > See All Events

    JOB OPPORTUNITIES

    Clinical Research Associate – Breast Cancer

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Fellow – CDK4/6 Biology and Inhibitor Resistance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Associate – Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    > See All Jobs

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