Mammary Cell News Volume 15.36 | Sep 14 2023

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    2023-09-14 | MCN 15.36


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.36 – 14 September, 2023
    TOP STORY

    RNF8 Ubiquitylation of XRN2 Facilitates R-loop Resolution and Restrains Genomic Instability in BRCA1 Mutant Cells

    Investigators sought to identify novel targets to selectively kill BRCA1-mutant cancers. They reported that loss of RNF8 significantly protected Brca1-mutant mice against mammary tumorigenesis.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Nimbolide Based Nanomedicine Inhibits Cancer Stem-Like Cells by Epigenetic Reprogramming of DNMTs-SFRP1-Wnt/β-Catenin Signaling Axis in Triple-Negative Breast Cancer

    Scientists investigated nimbolide, a limonoid triterpenoid that has potent anticancer properties but poor pharmacokinetics and low bioavailability limit its therapeutic application.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    ZNF500 Abolishes Breast Cancer Proliferation and Sensitizes Chemotherapy by Stabilizing P53 via Competing with MDM2

    The authors revealed that the ZNF500 mRNA and protein levels were higher in breast cancer tissues than those in their normal counterparts.
    [Cancer Science]

    Full Article

    BPIFB1 Promotes Metastasis of Hormone Receptor-Positive Breast Cancer via Inducing Macrophage M2-Like Polarization

    Scientists identified that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1), which played an important role in innate immunity, was significantly elevated in breast cancer and associated with lymph node metastasis.
    [Cancer Science]

    Full Article

    α-Catenin Acetylation Is Essential for Its Stability and Blocks Its Tumor Suppressor Effects in Breast Cancer through Yap1

    Researchers reported that α-catenin was acetylated by p300, and identified three acetylation sites, K45, K866, and K881. Conversely, they found that α-catenin acetylation could be reversed by deacetylase HDAC6.
    [Cancer Gene Therapy]

    Abstract

    Combined Dandelion Extract and All-Trans Retinoic Acid Induces Cytotoxicity in Human Breast Cancer Cells

    Scientists evaluated the antiproliferative and anti-metastasis activities of two natural compounds of dandelion and all-trans-retinoic acid in human MCF-7 and MDA-MB231 breast cancer cells.
    [Scientific Reports]

    Full Article

    Rare HER2 L796P Missense Mutation Promotes the Growth and Oncogenic Signaling in Breast Cancer Cells

    Researchers aimed to find potential HER2 mutations that would have an impact on breast cancer and investigated the underlying mechanism.
    [Proteomics Clinical Applications]

    Abstract

    FUNDC2, a Mitochondrial Outer Membrane Protein, Mediates Triple-Negative Breast Cancer Progression via the AKT/GSK3β/GLI1 Pathway

    Investigators found that FUN14 domain-Contains 2 (FUNDC2) expression in TNBC tissues was significantly higher than that in luminal subtype breast cancer tissues.
    [Acta Biochimica Et Biophysica Sinica]

    Full ArticleGraphical Abstract

    In Vitro Cytotoxic Effect of Stigmasterol Derivatives against Breast Cancer Cells

    The synthesized stigmasterol derivatives were screened for cytotoxicity against the hormone receptor-positive breast cancer, TNBC, and non-tumorigenic mammary epithelial cell lines using the resazurin assay.
    [BMC Complementary Medicine and Therapies]

    Full Article
    SepMateâ„¢ PBMC Isolation
    REVIEWS

    Emerging Systemic Therapy Options beyond CDK4/6 Inhibitors for Hormone Receptor-Positive HER2-Negative Advanced Breast Cancer

    The authors describe the findings from clinical trials using small molecule inhibitors, antibody–drug conjugates, and immunotherapy, providing insights into how these novel strategies may circumvent treatment resistance.
    [npj Breast Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Scientific Sleuths Spot Dishonest ChatGPT Use in Papers

    Many publishers, including Elsevier and Springer Nature, have said that authors can use ChatGPT and other large language model tools to help them produce their manuscripts, as long as they declare it.
    [Nature News]

    Editorial
    FEATURED EVENT

    The Tumor Landscape: Translating Mechanism to Therapy

    October 29 – November 1, 2023
    New York, New York, United States

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    JOB OPPORTUNITIES

    Research Technician – Cancer Research

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Associate – ARID4B in Breast Cancer

    The George Washington University – Washington D.C., United States

    Postdoctoral Fellow – Translational Breast Cancer Research

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Fellow – CDK4/6 Biology and Inhibitor Resistance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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