Mammary Cell News Volume 15.37 | Sep 21 2023

    By
    Bob
    -
    0
    16








    2023-09-21 | MCN 15.37


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.37 – 21 September, 2023
    TOP STORY

    Cooperative Regulation of Coupled Oncoprotein Synthesis and Stability in Triple-Negative Breast Cancer by EGFR and CDK12/13

    Using a candidate drug screen, the authors identified that inhibition of cyclin-dependent kinases 12 and 13 (CDK12/13) dramatically sensitized diverse models of TNBC to epidermal growth factor receptor (EGFR) blockade.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Heat-Shock Protein 90α Protects NME1 against Degradation and Suppresses Metastasis of Breast Cancer

    Gene knockdown and overexpression were employed to examine the impact of HSP90AA1 on intracellular NME1 degradation. The motility and invasiveness of breast cancer cells were examined in vitro.
    [British Journal of Cancer]

    Abstract

    KIAA1429/VIRMA Promotes Breast Cancer Progression by m6A-Dependent Cytosolic HAS2 Stabilization

    Researchers investigated the expression of N6-methyladenosine (m6A) regulatory proteins in breast cancer. They found that expression of KIAA1429/VIRMA was upregulated in breast cancer tissue and correlated positively with poor survival.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    TAZ Facilitates Breast Tumor Growth by Promoting an Immune-Suppressive Tumor Microenvironment

    To elaborate the roles of TAZ in TNBC, the authors depleted Taz in murine TNBC 4T1 cells, using either CRISPR/Cas9 or small hairpin RNA. TAZ depletion resulted in smaller tumors compared to the tumors generated by control cells.
    [Molecular Oncology]

    Abstract

    HER3 Functions as an Effective Therapeutic Target in Triple Negative Breast Cancer to Potentiate the Antitumor Activity of Gefitinib and Paclitaxel

    Researchers demonstrated that increased HER3 was an effective therapeutic target for TNBC and found that their anti-HER3 monoclonal antibody could potentially enhance the efficacy of gefitinib or paclitaxel in TNBC.
    [Cancer Cell International]

    Full Article

    A Comprehensive Analysis of the Role of QPRT in Breast Cancer

    To explore the clinical role of QPRT in breast cancer, gene expression, methylation levels, and prognostic value of QPRT in breast cancer were analyzed using TCGA data.
    [Scientific Reports]

    Full Article

    ZNF746 Promotes M2 Macrophage Polarisation and Favours Tumor Progression in Breast Cancer via the Jagged1/Notch Pathway

    Investigators reported that zinc finger protein 746 (ZNF746), a Krüppel-associated box and zinc finger protein, exhibited tumor-promoting properties in breast cancer.
    [Cellular Signalling]

    AbstractGraphical Abstract

    Performance of a RAD51-Based Functional HRD Test on Paraffin-Embedded Breast Cancer Tissue

    Scientists evaluated the performance of a functional RAD51-based homologous recombination deficiency (HRD) test for the identification of HRD breast cancer.
    [Breast Cancer Research and Treatment]

    Full Article

    Inhibiting SETD7 Methyl-Transferase Activity Impairs Differentiation, Lipid Metabolism, and Lactogenesis in Mammary Epithelial Cells

    The impact of inhibiting SETD7 catalytic activity on mammary epithelial cell differentiation was studied by focusing on genes associated with epithelial differentiation, lactogenesis, and lipid metabolism.
    [FEBS Letters]

    Abstract
    See how small molecules affect key signaling pathways in cancer research. Download your free wallchart now.
    REVIEWS

    Breast Cancer Organoids Derived from Patients: A Platform for Tailored Drug Screening

    Investigators deliver an overview of breast organoid culture techniques and outline future prospects for organoid modeling.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    US Patent Issued to TUCVM Researcher for Breast Cancer Research

    Tuskegee University College of Veterinary Medicine researcher Dr. Deepa Bedi was issued a US Patent for her methods for identifying aggressive breast cancer cells.
    [Tuskegee University]

    Press Release
    FEATURED EVENT

    Great Debates & Updates | Women’s Oncology

    November 1 – 3, 2023
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Mammary Tumors

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Clinical Research Associate – Breast Cancer

    Cedars-Sinai – Los Angeles, California, United States

    Clinical Research Assistant – Division of Breast Surgery

    City of Hope – Duarte, California, United States

    Assistant Professor – Cell Cycle Regulation and PI3K Signaling

    Georgetown University – Washington D.C., United States

    Postdoctoral Fellow – Translational Breast Cancer Research

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Mammary Cell News Twitter