Mammary Cell News Volume 15.40 | Oct 12 2023

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    2023-10-12 | MCN 15.40


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.40 – 12 October, 2023
    TOP STORY

    Luminal Rank Loss Decreases Cell Fitness Leading to Basal Cell Bipotency in Parous Mammary Glands

    Scientists found that loss of luminal Rank reduced the luminal progenitor pool and led to aberrant alveolar-like differentiation with high protein translation capacity in virgin mammary glands.
    [Nature Communications]

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    PUBLICATIONSRanked by the impact factor of the journal

    LncRNA EILA Promotes CDK4/6 Inhibitor Resistance in Breast Cancer by Stabilizing Cyclin E1 Protein

    Researchers reported that a cyclin E1–interacting lncRNA was up-regulated in CDK4/6 inhibitor (CDK4/6i)-resistant breast cancer cells and contributed to CDK4/6i resistance by stabilizing cyclin E1 protein.
    [Science Advances]

    Full Article

    Loss of PPARγ Activity Characterizes Early Protumorigenic Stromal Reprogramming and Dictates the Therapeutic Window of Opportunity

    Investigators primarily observed CD36 expression in adipocytes and intralobular capillaries within the disease-free breast.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Downregulation of EphA2 Stability by RNF5 Limits Its Tumor-Suppressive Function in HER2-Negative Breast Cancers

    Researchers revealed that RNF5 negatively regulated Ephrin receptor A2 (EphA2) properties and suppressed its tumor-suppressive function in HER2-negative breast cancers.
    [Cell Death & Disease]

    Full Article

    PRMT6 Methylation of STAT3 Regulates Tumor Metastasis in Breast Cancer

    Investigators established that PRMT6 exerted a positive regulatory influence on breast cancer metastasis through both in vivo and in vitro experiments.
    [Cell Death & Disease]

    Full Article

    CircANKRD17 Promotes Glycolysis by Inhibiting miR-143 in Breast Cancer Cells

    Scientists reported that the circular RNA circ ankyrin repeat domain 17 (ANKRD17) functioned as a key regulator for glycolysis to promote cell growth, migration, invasion, and cell-cycle progression in breast cancer cells.
    [Journal Of Cellular Physiology]

    Abstract

    Tetracaine Downregulates Matrix Metalloproteinase Activity and Inhibits Invasiveness of Strongly Metastatic MDA-MB-231 Human Breast Cancer Cells

    The authors explored whether tetracaine would reduce the invasive characteristics of breast cancer cells. Importantly, tetracaine suppressed the migratory, invasive, and adhesive capacities of MDA-MB-231 cells.
    [Chemico-Biological Interactions]

    Abstract

    Resistance to Abemaciclib Is Associated with Increased Metastatic Potential and Lysosomal Protein Deregulation in Breast Cancer Cells

    Using estrogen receptor positive breast cancer cell models, researchers showed that acquired resistance to abemaciclib was accompanied by increase in metastatic potential.
    [Molecular Carcinogenesis]

    Full Article

    PRIMA-1 Synergizes Olaparib-Induced Cell Death in p53 Mutant Triple Negative Human Breast Cancer Cell Line via Restoring p53 Function, Arresting Cell Cycle, and Inducing Apoptosis

    Scientists assessed the effect of restoring p53 using PRIMA-1 on the anti-cancer activity of olaparib against TP53-mutant TNBC cells and explored the optimum synergistic concentrations and the underlying mechanism.
    [Canadian Journal Of Physiology And Pharmacology]

    Abstract
    Your Online Resource for Cell Visualization. View StainsFile.
    REVIEWS

    Roles of Long Noncoding RNA in Triple-Negative Breast Cancer

    The authors review the current literature on the roles of lncRNAs in the pathogenesis, therapy resistance, and prognosis of patients with TBNC.
    [Cancer Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Tuskegee University Receives Record $25 Million NIH Grant

    The Tuskegee University Research Centers in Minority Institutions Center for Biomedical Research has received a $25 million grant from the National Institute on Minority Health and Health Disparities to help researchers develop health solutions for minority populations.
    [Tuskegee University]

    Press Release
    FEATURED EVENT

    Generation and Application of Organoid Disease Models

    October 29 – November 3, 2023
    Hinxton, England, United Kingdom

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    JOB OPPORTUNITIES

    Postdoctoral Positions – HER2+ Breast Cancer Cells

    NYU Medical Center – New York, New York, United States

    Associate Professor – DNA Repair

    Stanford University – Stanford, California, United States

    Postdoctoral Scholarship – Structural Biology in Targeted Cancer Therapy

    Ume̴ University РUme̴, Sweden

    Postdoctoral Fellow – Mammary Tumors

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Faculty Positions – Cancer Research

    Houston Methodist Research Institute – Houston, Texas, United States

    > See All Jobs

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