Mammary Cell News Volume 15.41 | Oct 19 2023

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    2023-10-19 | MCN 15.41


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.41 – 19 October, 2023
    TOP STORY

    PML Modulates Epigenetic Composition of Chromatin to Regulate Expression of Pro-Metastatic Genes in Triple-Negative Breast Cancer

    Researchers examined promyelocytic leukemia (PML) chromatin association in TNBC cell lines, where it exerted important oncogenic functions.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Differential DNA Damage Repair and PARP Inhibitor Vulnerability of the Mammary Epithelial Lineages

    The authors showed that the DNA damage response in normal mammary gland inherently depended on the epithelial cell lineage identity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    RACK1 Facilitates Breast Cancer Progression by Competitively Inhibiting the Binding of β-Catenin to PSMD2 and Enhancing the Stability of β-Catenin

    Investigators showed that receptor for activated C kinase 1 (RACK1) was required for breast cancer cell proliferation in vitro and tumor growth in vivo.
    [Cell Death & Disease]

    Full Article

    Pyrroline-5-Carboxylate Reductase 1 Reprograms Proline Metabolism to Drive Breast Cancer Stemness under Psychological Stress

    Researchers identified that proline synthetase PYCR1 was critical for breast cancer stemness and tumor growth. PYCR1-synthesized proline activated cGMP-PKG signaling to enhance cancer stem-like traits.
    [Cell Death & Disease]

    Full Article

    KLHL29-Mediated DDX3X Degradation Promotes Chemosensitivity by Abrogating Cell Cycle Checkpoint in Triple-Negative Breast Cancer

    Scientists identified KLHL29, which was an understudied member of the Kelch-like gene family, as a crucial tumor suppressor that regulates chemosensitivity in TNBC.
    [Oncogene]

    Full Article

    Antitumor Effect of Algae Silver Nanoparticles on Human Triple Negative Breast Cancer Cells

    The effects of Algae- silver nanoparticles synthesized were tested on MDA-MB-231 human breast cancer cells and HaCat human keratinocyte normal cells.
    [Biomedicine & Pharmacotherapy]

    Full Article

    SGCE Promotes Breast Cancer Stemness by Promoting the Transcription of FGF-BP1 by Sp1

    Researchers found that ε-Sarcoglycan (SGCE) depletion reduces breast cancer stem cells, partially through inhibiting the transcription of FGF-BP1, a secreted oncoprotein.
    [Journal of Biological Chemistry]

    Full Article

    Dual Targeting of H2S Synthesizing Enzymes; Cystathionine β-Synthase and Cystathionine γ-Lyase by miR-939-5p Effectively Curbs Triple Negative Breast Cance

    Scientists shed light on the reciprocal relationship between cystathionine-β-synthase and cystathionine-γ-lyase and on the importance of their dual targeting, particularly in TNBC.
    [Heliyon]

    Full Article

    Circular RNA AGFG1 Motivates Breast Cancer Cell Proliferation, Invasion, Migration, and Glycolysis by Controlling MicroRNA-653-5p/14-3-3 Protein Epsilon

    The investigators elucidated the biological role of circAGFG1 in breast cancer and explored its potential downstream molecular mechanisms.
    [Acta Biochimica Polonica]

    Abstract
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    REVIEWS

    Targeting Breast Cancer Stem Cells through Retinoids: A New Hope for Treatment

    The authors summarize the current understanding of breast cancer stem cells, their biomarkers, and the associated signaling pathways.
    [Critical Reviews in Oncology/Hematology]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Researchers Are Investigating How to Stop Triple Negative Breast Cancer Spreading

    The charity Breast Cancer Now has awarded £249,992 to Dr. Sankari Nagarajan and her team at The University of Manchester to help discover why some TNBCs spread to other parts of the body and whether existing drugs can be repurposed to stop this.
    [Manchester Cancer Research Centre]

    Press Release
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    November 28 – 30, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Research

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    Faculty Positions – Cancer Research

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Positions – HER2+ Breast Cancer Cells

    NYU Medical Center – New York, New York, United States

    Associate Professor – DNA Repair

    Stanford University – Stanford, California, United States

    Postdoctoral Scholarship – Structural Biology in Targeted Cancer Therapy

    Ume̴ University РUme̴, Sweden

    > See All Jobs

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