 | | Vol. 15.44 – 9 November, 2023 |
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| Researchers described the development of a long-term adult stem cell-derived mammary mini gland culture system that supports robust three-dimensional outgrowths.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors examined the metabolic adaptations of metastasis-initiating cells in female breast cancer and how those shaped their metastatic phenotype.
[Nature Communications] |
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| Investigators demonstrated that the simultaneous inhibition of lysyl oxidase-like 2 (LOXL2) and bromodomain-containing protein 4 (BRD4) synergistically limited TNBC proliferation in vitro and in vivo.
[EMBO Molecular Medicine] |
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| The effect of doxazosin on TNBC cell lines in vitro was evaluated in terms of cell viability, apoptosis, c-MET/EGFR signaling pathway, molecular docking studies, and impact on cancer stem cell-like properties.
[Journal of Experimental & Clinical Cancer Research] |
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| In breast tumors, PRMT1 overexpression was associated with increased SRSF1 arginine methylation and aberrant exon inclusion, which were critical for breast cancer cell growth.
[Cell Reports] |
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| Scientists reported a combined in vitro/in vivo genome-wide CRISPR synthetic lethality screening approach in a relevant TNBC cell line model to identify several targets responsible for paclitaxel resistance.
[Oncogenesis] |
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| Circular RNA RHOT1 exhibited significantly high expression in exosomes derived from the serum of breast cancer patients and breast cancer cell lines, which suggested its potential diagnostic value.
[Cancer Cell International] |
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| Researchers found that F2, the gene encoding thrombin, was strongly upregulated in breast cancer compared with normal samples and that lower F2 levels were associated with poorer prognosis in breast cancer patients.
[Translational Oncology] |
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| Scientists analyzed the online datasets and found that Alpha-2-glycoprotein 1, zinc-binding (AZGP1) was highly expressed in breast cancer tissues and its expression was negatively correlated with the survival of breast cancer patients.
[Environmental Toxicology] |
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| Researchers studied the impact of 1,25 dihydroxycholecalciferols (1,25(OH)2D3) and genistein on the proliferation, progression, and metastasis of MCF-7 and MDA-MB-231 cells and investigated whether there was a synergistic effect between genistein and 1,25(OH)2D3.
[Heliyon] |
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| Scientists described the current utilization of antibody–drug conjugates (ADCs) and discussed the prospects of ADC combination therapy for TNBC.
[Cellular and Molecular Life Sciences] |
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| The authors emphasize the most recent research on nutraceuticals, medication repositioning, and novel therapeutic strategies for the treatment of TNBC.
[Molecular Biology Reports] |
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| Immutep Limited announced the open-label safety lead-in of its integrated AIPAC-003 Phase II/III trial evaluating for the very first time 90mg of eftilagimod alpha in combination with paclitaxel has been completed with no safety or tolerability issues.
[Immutep Limited] |
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| The International Society for Stem Cell Research (ISSCR) and publisher Cell Press announced the extension of their partnership to publish the ISSCR’s open-access, peer-reviewed journal, Stem Cell Reports.
[The International Society for Stem Cell Research] |
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| December 4 – 7, 2023
Dublin, Ireland |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Galway – Galway, Ireland |
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