Mammary Cell News Volume 16.02 | Jan 18 2024

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    2024-01-18 | MCN 16.03


    Mammary Cell News by STEMCELL Technologies
    Vol. 16.02 – 18 January, 2024
    TOP STORY

    MRE11 Liberates cGAS from Nucleosome Sequestration during Tumorigenesis

    The authors reported that the DNA double-strand break sensor MRE11 suppressed mammary tumorigenesis through a pivotal role in regulating cGAS activation.
    [Nature]

    Full ArticlePress Release
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    Identification of Aberrant Luminal Progenitors and mTORC1 as a Potential Breast Cancer Prevention Target in BRCA2 Mutation Carriers

    Using preneoplastic specimens from age-matched, premenopausal females, scientists showed broad dysregulation across the luminal compartment in BRCA2mut/+ tissue, including expansion of aberrant ERBB3lo luminal progenitor and mature cells, and the presence of atypical ER-positive lesions.
    [Nature Cell Biology]

    AbstractPress Release

    Breast Cancer Immunopeptidomes Contain Numerous Shared Tumor Antigens

    Investigators characterized the repertoire of MHC I–associated peptides presented by hormone receptor–positive breast cancer and TNBC tumors. They identified 25 tumor-specific antigens mainly deriving from aberrantly expressed regions.
    [Journal Of Clinical Investigation]

    Full ArticleGraphical Abstract

    The HER2-Directed Antibody-Drug Conjugate DHES0815A in Advanced and/or Metastatic Breast Cancer: Preclinical Characterization and Phase I Trial Results

    Researchers reported a dose-escalation study in patients with HER2-positive metastatic breast cancer, with the primary objective of evaluating the safety and tolerability of DHES0815A.
    [Nature Communications]

    Full ArticlePress Release

    Genomic and Transcriptomic Analysis of Breast Cancer Identifies Novel Signatures Associated with Response to Neoadjuvant Chemotherapy

    Scientists performed whole-exome and RNA sequencing on 233 samples from 50 breast cancer patients with rigorously defined responses to neoadjuvant chemotherapy and analyzed changes in the multi-omics landscape.
    [Genome Medicine]

    Full Article

    Fibroblast-Induced Mammary Epithelial Branching Depends on Fibroblast Contractility

    Investigators employed fibroblast-organoid or fibroblast-spheroid co-culture systems and time-lapse imaging to reveal that physical contact between fibroblasts and epithelial cells and fibroblast contractility are required to induce mammary epithelial branching.
    [PLOS Biology]

    Full Article

    ZO-1 Regulates the Migration of Mesenchymal Stem Cells in Cooperation with α-Catenin in Response to Breast Tumor Cells

    Scientists identified zonula occludens-1 (ZO-1) as a specific intrinsic molecule that plays a vital role in mediating the collective migration of mesenchymal stem cells towards breast tumor cells and transforming growth factor beta, which was a crucial factor secreted by breast tumor cells.
    [Cell Death Discovery]

    Full Article

    RUNX2 Prompts Triple Negative Breast Cancer Drug Resistance through TGF-β Pathway Regulating Breast Cancer Stem Cells

    Researchers took a multifaceted approach from in vitro and in vivo experiments to validate the relationship between RUNX2 and TGF-β and to search for their pathogenic mechanisms in chemoresistance.
    [Neoplasia]

    Full Article

    Stiffness-Dependent MSC Homing and Differentiation into CAFs – Implications for Breast Cancer Invasion

    By analyzing previously published single-cell RNA sequencing datasets, scientists established the existence of a subpopulation of cells in primary tumors, secondary sites, and circulatory tumor cell clusters of highly aggressive TNBC that co-express mesenchymal stem cells and cancer-associated fibroblast markers.
    [Journal Of Cell Science]

    Abstract
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    REVIEWS

    Targeting Systemic and Gut Microbial Metabolism in ER+ Breast Cancer

    The authors review recent literature concerning the metabolic pathways regulated in ER+ breast tumors by the availability of nutrients and endocrine therapies and summarizes research on how changes in systemic and gut microbial metabolism can affect ER activity and responsiveness to endocrine therapy.
    [Trends In Endocrinology And Metabolism]

    Abstract
    INDUSTRY AND POLICY NEWS

    European Commission Approves Roche’s Tecentriq SC, the EU’s First PD-(L)1 Cancer Immunotherapy Subcutaneous Injection for Multiple Cancer Types

    Until now, Tecentriq has been given directly into patients’ veins by IV infusion which takes approximately 30-60 minutes. The new subcutaneous injection will cut treatment time to approximately seven minutes, with most injections taking between four and eight minutes.
    [Roche]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Researchers – Advanced Imaging & 3D Genome Analysis in Cancer Biology

    Karolinska Institutet – Solna, Sweden

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

    Postdoctoral Research Associate – Morphogenesis of the Lung and Mammary Gland

    Princeton University – Princeton, New Jersey, United States

    Postdoctoral Researcher – Computational Cancer Evolution

    Human Technopole – Milan, Italy

    Research Fellow – Breast and Lung Cancer Diagnosis

    University of Melbourne – Melbourne, Australia

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