 | | Vol. 16.03 – 25 January, 2024 |
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| Researchers reported results for the secondary end point overall survival. Postmenopausal women with ER+/HER2– advanced breast cancer (ABC) without previous systemic therapy for ABC were randomly assigned 2:1 to palbociclib plus letrozole or placebo plus letrozole.
[Journal Of Clinical Oncology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the breast tumor coagulome and its relation to prognosis, treatment response to chemotherapy, and the tumor microenvironment.
[Journal Of Thrombosis And Haemostasis] |
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| Investigators developed an orally bioavailable rocaglate-based molecule, MG-002, which hindered ribosome recruitment and scanning via unscheduled and non-productive RNA clamping by the eukaryotic translation initiation factor 4A RNA helicase.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors demonstrated that the presence of extracellular matrix (ECM) supported the growth of invasive breast cancer cells, but not non-transformed mammary epithelial cells, under amino acid starvation, through a mechanism that required macropinocytosis-dependent ECM uptake.
[PLOS Biology] |
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| A combination of an androgen receptor (AR) inhibitor and a selective histone deacetylase inhibitor was used to treat AR‑positive TNBC cell lines, and a synergistic effect of these drugs was observed.
[International Journal Of Oncology] |
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| The authors examined the interaction between LYN kinase and BRCA1 loss-of-function in an in vivo mouse mammary tumor model, using conditional knockout Brca1 and Lyn alleles.
[Disease Models & Mechanisms] |
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| Researchers evaluated different treatment approaches in breast cancer cells. The expression of some membrane markers relevant to resistance was assessed.
[European Journal Of Pharmacology] |
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| Investigators found that Metadherin was overexpressed in breast cancer and was significantly correlated with individual cancer stage, age, subclasses, menopause and nodal metastasis status.
[Scientific Reports] |
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| Scientists explored whether chlorogenic acid attenuated lipopolysaccharide-induced inflammation and decreased milk fat in bovine mammary epithelial cells.
[Heliyon] |
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| The authors provide a comprehensive overview of the characteristics of breast cancer metastases, shedding light on the pivotal roles of immune and resident cells in the development of distinct metastatic foci.
[Cell Communication And Signaling] |
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| Scientists discuss the mechanism of action of various a disintegrin and metalloproteas (ADAM) molecules, their relation to pathogenic processes of breast cancer, and their potential as possible targets for breast cancer treatment.
[Heliyon] |
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| Millions of American women over age 40 receive regular mammograms to screen for breast cancer. About half of them turn out to have dense breast tissue — which makes screening significantly more complicated.
[STAT] |
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| Researchers from the University of California San Diego are using cancerous tumor grown using cells from breast cancer patients to explore the effectiveness of certain cancer treatments. The lack of gravity strains the cells and can speed up the aging process.
[The Messenger] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | Sunnybrook Health Science Centre – Toronto, Ontario, Canada |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Princeton University – Princeton, New Jersey, United States |
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| | Human Technopole – Milan, Italy |
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