Mammary Cell News Volume 16.04 | Feb 1 2024

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    2024-02-01 | MCN 16.04


    Mammary Cell News by STEMCELL Technologies
    Vol. 16.04 – 1 February, 2024
    TOP STORY

    Mismatch Repair Protein MLH1 Suppresses Replicative Stress in BRCA2 Deficient Breast Tumors

    Scientists identified mismatch repair gene, MLH1 as a genetic interactor of BRCA2 whose over-expression supported the viability of Brca2-null cells. Mechanistically, they showed that MLH1 interactd with Flap endonuclease 1 and competed to process the RNA flaps of Okazaki fragments.
    [Journal Of Clinical Investigation]

    Abstract
    Reliably Generate Spheroids with AggreWell™
    PUBLICATIONSRanked by the impact factor of the journal

    Injectable Nano-in-Gel Vaccine for Spatial and Temporal Control of Vaccine Kinetics and Breast Cancer Postsurgical Therapy

    The authors introduced a one-shot injectable nano-in-gel vaccine (NIGel-Vax) for postoperative breast cancer therapy. The NIGel-Vax was constructed by mixing protein antigens with PEI-4BImi-Man adjuvant and then encapsulated in a hydrogel made with oxidized dextran and 4-arm PEG-ONH2.
    [ACS Nano]

    AbstractGraphical Abstract

    Targeting EMSY-Mediated Methionine Metabolism Is a Potential Therapeutic Strategy for Triple-Negative Breast Cancer

    Investigators discovered that EMSY, inducing a BRCAness phenotype, was preferentially expressed in breast CSCs, promoted ALDH+ cells enrichment, and was positively correlated with poor relapse-free survival.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Blocking LBH Expression Causes Replication Stress and Sensitizes Triple-Negative Breast Cancer Cells to ATR Inhibitor Treatment

    Researchers demonstrated a novel role for LBH in promoting TNBC cell survival. Depletion of LBH in multiple TNBC cell models triggered apoptotic cell death both in vitro and in vivo and led to S-G2M cell cycle delays.
    [Oncogene]

    AbstractGraphical Abstract

    Long Noncoding RNA DLEU2 and ROR1 Pathway Induces Epithelial-to-Mesenchymal Transition and Cancer Stem Cells in Breast Cancer

    Investigators found that lncRNA DLEU2 and ROR1 were specifically upregulated in tumor tissues compared to their normal counterparts in TCGA, PubMed GEO datasets, and samples from archived breast cancer tumor tissues.
    [Cell Death Discovery]

    Full Article

    Studying the Effects of Secondary Metabolites Isolated from Cycas thouarsii R.Br. Leaves on MDA-MB-231 Breast Cancer Cells

    The authors elucidated the possible anticancer potential of four compounds 7, 4′, 7′′, 4′′′-tetra-O-methyl amentoflavone, hesperidin, ferulic acid, and chlorogenic acid that are isolated from Cycas thouarsii leaves n-butanol fraction for the first time.
    [Artificial Cells Nanomedicine And Biotechnology]

    Full Article

    Exploration of MELK as a Downstream of Del-1 and Druggable Targets in Triple-Negative Breast Cancer

    Scientists investigated the expression of Del-1 and maternal embryonic leucine zipper kinase (MELK), mRNA levels in eight different TNBC cell lines were analyzed.
    [Breast Cancer Research And Treatment]

    Abstract

    Propranolol Inhibits EMT and Metastasis in Breast Cancer through miR-499-5p-Mediated Sox6

    Researchers found that propranolol significantly reduced lung metastasis in 4T1 murine breast cancer cells. In vitro and in vivo experiments demonstrated that propranolol inhibited the epithelial–mesenchymal transition as evidenced by Western Blot analysis.
    [Journal Of Cancer Research And Clinical Oncology]

    Full Article

    Differential DNA Methylation and CTCF Binding between the ESR1 Promoter A of MCF-7 and MDA-MB-231 Breast Cancer Cells

    The authors probed if the transcription factor CTCF plays a role in the differential expression of ESR1 in the breast cancer cell lines MCF-7 and MDA-MB-231.
    [Molecular Biology Reports]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Cell-Cell Communication Characteristics in Breast Cancer Metastasis

    Scientists provide a comprehensive overview of the characteristics of breast cancer metastases, shedding light on the pivotal roles of immune and resident cells in the development of distinct metastatic foci.
    [Cell Communication And Signaling]

    Full ArticleGraphical Abstract

    RNA-Binding Proteins in Breast Cancer: Biological Implications and Therapeutic Opportunities

    Investigators summarize the regulatory mechanisms of RNA-binding proteins (RBPs) and their signaling crosstalk in breast cancer. They emphasize the potential of certain RBPs as prognostic factors due to their effects on proliferation, invasion, apoptosis, and therapy resistance of breast cancer cells.
    [Critical Reviews In Oncology/Hematology]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Phase II Study of Denifanstat Looks to Add First-in-Class Agent to HER2+Breast Cancer Treatment Armamentarium

    With the development of the first-in-class fatty acid synthase inhibitor denifanstat, which is being evaluated in a Phase II trial, investigators are hoping that the agent can be a key component in restoring sensitivity to standard treatments for patients with HER2- positive metastatic breast cancer.
    [OncLive]

    Press Release
    FEATURED EVENT

    46th JSTCT Annual Meeting (JSTCT2024) Japanese Society for Transplantation and Cellular Therapy

    March 21 – 23, 2024
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Clinical Research Physician – Ovarian and Breast Cancer

    National Cancer Institute – Bethesda, Maryland, United States

    PhD Studentship – 3D Collagen Fiber Networks in Breast Cancer Progression

    University of Nottingham – Nottingham, England, United Kingdom

    Postdoctoral Researchers – Advanced Imaging & 3D Genome Analysis in Cancer Biology

    Karolinska Institutet – Solna, Sweden

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

    Postdoctoral Research Associate – Morphogenesis of the Lung and Mammary Gland

    Princeton University – Princeton, New Jersey, United States

    > See All Jobs

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