 | | Vol. 16.06 – 15 February, 2024 |
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| Investigators reported the results of 24 women, 50% with hormone receptor-positive breast cancer and 50% with advanced TNBC, treated with entinostat + nivolumab + ipilimumab from the dose escalation and expansion cohort of ETCTN-9844.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Markable reductions were observed in tumorigenesis of estrogen receptor (ER)− breast cancer cells by applying both supernatants from Tamoxifen -treated ER+ cells and a transwell co-culture system, validating the presence of a TAM-induced bystander effect.
[Cell Death & Disease] |
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| Investigators found that MAP1B interacted with key components for invadopodia formation, cortactin, and Tks5, the latter of which was a PtdIns(3,4)PM2-binding and scaffold protein that localized to invadopodia.
[Journal Of Cell Biology] |
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| MicroRNA-21 was employed as a biomarker for breast cancer, and miR-21 induced the quenching of the electrochemiluminescence signal from luminophores via a strategically designed catalytic three-hairpin assembly circuit.
[Analytical Chemistry] |
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| Researchers utilized the MMTV-cre, The Ubiquitin Specific Peptidase 22 (Usp22)fl/fl transgenic mouse model to study the involvement of USP22 in the stem cell-like properties of the growing mammary tissue.
[Cell Communication And Signaling] |
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| The authors developed a mechanistic quantitative systems pharmacology model of the pathophysiology of HER2+ metastatic breast cancer that was extensively calibrated and validated against multiscale data to quantitatively predict and characterize the signal transduction under different therapeutic interventions.
[Acta Pharmacologica Sinica] |
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| The Cancer Genome Atlas and Gene Expression Omnibus. The prognostic signature of metabolism-related lncRNAs was constructed using the least absolute shrinkage and selection operator cox regression analysis.
[Scientific Reports] |
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| To determine if transcriptional differences between tumor cells lead to differential drug responses, researchers performed single cell RNA-seq on cell line and PDX models of breast cancer revealing cell subpopulations in states associated with resistance to standard-of-care therapies.
[Scientific Reports] |
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| The cell viability, cell proliferation, lactate dehydrogenase showed potential anti-proliferative in dose dependent manner, these results were well correlated with hoesch stain and DNA fragmentation on MDA-MB-231 breast cancer cell lines.
[Journal of Receptors and Signal Transduction] |
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| The authors explore the regulatory mechanisms governing alternative splicing processes, intricate signal transduction pathways, and the intricate association linking insulin receptor (IR-A) and IR-B splicing variants to breast and prostate cancer tumorigenesis.
[Cancer Cell International] |
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| Dr. Taran Gujral and his lab created a drug-matching platform that uses artificial intelligence to help researchers, clinicians and, most importantly, patients find additional uses for drugs that have already gone through clinical trials and received approval from the US FDA.
[Fred Hutch Cancer Center] |
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| McMaster biologist Juliet Daniel is one of three Canadian scientists to be named a Black Innovator in Research and Medicine by the Government of Canada’s Canadian Intellectual Property Office, for her pioneering research on TNBC.
[McMaster University] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Dana-Farber – Boston, Massachusetts, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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