 | | Vol. 16.07 – 22 February, 2024 |
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| Investigators used an autochthonous somatic TNBC mouse model, in which mutant p53 could be toggled on and off genetically while leaving the tumor microenvironment intact and wild-type for p53 to identify physiological dependencies on mutant p53.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using inducible models of human mammary epithelial cells, the authors demonstrated that the oncogenic activation of RAS promoted zinc finger e-box binding homeobox dependent epithelial-to-mesenchymal plasticity, which was necessary for malignant transformation.
[Science Advances] |
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| Using CD24 knock-down and over-expression TNBC models, in vitro and in vivo analysis revealed that CD24 was a tumor suppressor in metastatic TNBC.
[Cancer Letters] |
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| Differentially expressed circular RNAs (circRNAs) in breast cancer were identified by integrating breast tumor-associated somatic copy number variation data and circRNA high-throughput sequencing.
[Cell Death & Disease] |
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| Researchers discovered a novel long noncoding RNA (lncRNA) whose expression was significantly increased in breast cancer tissues.
[Oncogene] |
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| Human TNBC cell lines and patient-derived organoids were used in combination with real-time metabolic assays to evaluate the effect of neoadjuvant chemotherapy on tumor cell metabolism, in particular glycolysis.
[Breast Cancer Research] |
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| Scientists synthesized a series of toxoflavin analogs, among which D43 displayed a significant dose-dependent inhibitory effect on the proliferation of TNBC cells.
[Scientific Reports] |
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| Investigators selected RNA aptamers internalized by MGSO-3 cells derived from a primary site previously established in their laboratory.
[Journal Of Cellular Biochemistry] |
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| Researchers explored the role of p300 in the context of paclitaxel resistance in TNBC cells, focusing on its interaction with the phosphoenolpyruvate carboxykinase 1 (PCK1)/adenosine monophosphate-activated protein kinase (AMPK) pathway.
[The Pharmacogenomics Journal] |
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| The authors summarize the available information on the action exerted by all-trans retinoic acid on the breast cancer micro-environment, an emerging determinant of the progression and invasive behaviour of solid tumors.
[Cell Communication And Signaling] |
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| Blackford and b-rayZ announced a commercial partnership to bring the b-box plus solution to healthcare professionals.
[b-rayZ] |
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| March 17 – 22, 2024
Galveston, Texas, United States |
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| | Cedars Sinai Medical Center – Los Angeles, California, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Dana-Farber – Boston, Massachusetts, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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