Mammary Cell News Volume 16.11 | Mar 21 2024

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    Emily Salmini
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    2024-03-21 | MCN 16.11


    Mammary Cell News by STEMCELL Technologies
    Vol. 16.11 – 21 March, 2024
    TOP STORY

    Thermophoretic Glycan Profiling of Extracellular Vesicles for Triple-Negative Breast Cancer Management

    Scientists reported that a lectin-based thermophoretic assay streamlined vibrating membrane filtration and thermophoretic amplification, allowing for rapid, sensitive, selective, and cost-effective extracellular vesicle glycan profiling in TNBC plasma.
    [Nature Communications]

    Full Article
    Discover new celli Isolation technologies
    PUBLICATIONSRanked by the impact factor of the journal

    Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-Like Breast Cancer

    Among the hyperactive candidate transcription factors of basal-like breast cancer (BLBC) identified by bioinformatic analysis, POU4F1 was uniquely upregulated in BLBC and was associated with poor prognosis.
    [Advanced Science]

    Full Article

    E-Cadherin Interacts with EGFR Resulting in Hyper-Activation of ERK in Multiple Models of Breast Cancer

    Using novel multi-compartment organoids and multiple in vivo models, investigators showed that E-cadherin promoted a hyper-proliferative phenotype in breast cancer cells via interaction with the transmembrane receptor EGFR.
    [Oncogene]

    Abstract

    Linc00707 Regulates Autophagy and Promotes the Progression of Triple Negative Breast Cancer by Activation of PI3K/AKT/mTOR Pathway

    Linc00707 promoted TNBC cell proliferation, migration, and invasion. Knockdown of Linc00707 influenced autophagy via PI3K/AKT/mTOR signaling pathway in TNBC cells.
    [Cell Death Discovery]

    Full Article

    MCT4-Driven CAF-Mediated Metabolic Reprogramming in Breast Cancer Microenvironment Is a Vulnerability Targetable by miR-425-5p

    Investigators assessed the expression of miR-425-5p and its target monocarboxylate transporter (MCT4) in breast cancer associated fibroblasts and normal fibroblasts.
    [Cell Death Discovery]

    Full Article

    Extracellular Vesicles Derived from SARS-CoV-2 M-Protein-Induced Triple Negative Breast Cancer Cells Promoted the Ability of Tissue Stem Cells Supporting Cancer Progression

    The effects of M-protein on the ability of extracellular vesicles derived from TNBC cells to regulate the functions of tissue stem cells facilitating the tumor microenvironment were examined.
    [Frontiers In Oncology]

    Full Article
    Learn how to avoid jargon and use blogs and social media channels to inform the public about your science
    REVIEWS

    The Movement of Mitochondria in Breast Cancer: Internal Motility and Intercellular Transfer of Mitochondria

    The authors focus on the effect of mitochondria movement on breast cancer progression.
    [Clinical & Experimental Metastasis]

    Full Article
    INDUSTRY AND POLICY NEWS

    Puma Biotechnology Announces FDA Allowance to Proceed under IND for Alisertib in HER2-Negative, Hormone Receptor-Positive Metastatic Breast Cancer

    Puma Biotechnology, Inc. was notified by the US FDA that its investigational new drug application submission has been reviewed, and they can proceed with the clinical development of alisertib for the treatment of patients with HER2-negative, hormone receptor-positive metastatic breast cancer.
    [Puma Biotechnology, Inc.]

    Press Release
    FEATURED EVENT

    AI in Biomedicine

    May 1 – 3, 2024
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Biochemistry and Molecular Biology

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Research Fellow – Liposarcoma, Breast Cancer, and NSCLC

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Research Assistant – Breast Surgical Oncology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Cancer Epigenomics

    Princess Margaret Cancer Centre – Toronto, Ontario, Canada

    Postdoctoral Researcher – Breast Cancer Metastasis

    Montreal Clinical Research Institute – Montréal, Québec, Canada

    > See All Jobs

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