 | | Vol. 16.12 – 28 March, 2024 |
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| Using single-cell RNA sequencing, multiplex staining, and serum analysis in inflammatory breast cancer (IBC) patients, researchers identified enrichment of a subgroup of luminal progenitor cells containing high expression of the neurotropic cytokine pleiotrophin in IBC tumors.
[Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that a specific ERβ agonist, LY500307, potently induced R-loop formation and DNA damage in TNBC cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors discovered that overexpression of Hpa2 in breast carcinoma cells resulted in bigger tumors, whereas targeting Hpa2 to the cell nucleus attenuated tumor growth and tumor metastasis.
[Cell Death & Disease] |
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| Researchers investigated the interplay between WW domain-containing oxidoreductase (WWOX) and BRCA1, both frequently inactivated in TNBC, on mammary tumor development and on DNA double-strand break repair choice.
[Cell Death Discovery] |
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| Investigators analyzed the role of mitophagy in the treatment of the most common anticancer drug, doxorubicin, in different models of breast cancer.
[Cell Death Discovery] |
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| Researchers reported that transient receptor potential cation channel subfamily V member (TRPV4) was prominently expressed in the stem/progenitor cell populations of the mammary epithelium, and seemed important for lineage-specific differentiation.
[Scientific Reports] |
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| The authors summarize the biological rationale behind the use of poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors in breast cancer, as well as the available evidence, recent progress, and potential future applications of these agents.
[JAMA Oncology] |
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| Scientists delve into the intrinsic stresses that cancer cells encounter throughout the metastatic journey and the additional stresses induced by therapeutic interventions.
[Disease Models & Mechanisms] |
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| ProLynx, Inc. announced that the first patient was included in Topology by investigator Dr. Delphine Loirat, with a Phase II clinical trial investigating PLX038 for locally-advanced or metastatic TNBC.
[ProLynx, Inc. (BioSpace)] |
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| Springer Nature and the Breast Cancer Research Foundation (BCRF) announced the Rising Scholars: Breast Cancer program, a partnership between Nature Portfolio and BCRF which provides early career researchers in the field of cancer with additional resources for professional development.
[Springer Nature] |
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| The University of Texas (UT) at Tyler received a $447,195 grant from the National Institutes of Health to support the research of Dr. May Abdelaziz in HER2, a protein that promotes the growth of breast cancer.
[The University of Texas at Tyler] |
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| May 6 – 8, 2024
Prague, Czech Republic |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Princess Margaret Cancer Centre – Toronto, Ontario, Canada |
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| | Montreal Clinical Research Institute РMontr̩al, Qu̩bec, Canada |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
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