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| Scientists identified a subset of myofibroblast cancer-associated fibroblast (CAFs) that were senescent (senCAF) in mouse and human breast tumors. SenCAFs were present in HER2+, ER+, and triple-negative breast cancer and in ductal carcinoma in situ (DCIS) where they predicted tumor recurrence.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators revealed a gene activation program that required arginine methylation established by coactivator-associated arginine methyltransferase 1 (CARM1) on a key chromatin remodeler.
[Nucleic Acids Research] |
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| Researchers observed that interleukin-1 receptor type 2 (IL1R2) blockade strongly attenuated macrophage recruitment and the polarization of tumor-associated macrophages to inhibit breast tumor-initiating cell (BTIC) self-renewal and CD8+ T cell exhaustion.
[Cancer Research] |
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| Using preclinical models of spontaneous breast cancer metastasis, scientists investigated the impact of SMAD4 on the ability of bone morphogenetic protein 4 (BMP4) to regulate tumor growth and metastasis.
[Cell Communication and Signaling] |
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| The authors investigated the effects of miR-99a and miR-143 in single expression plasmids for breast cancer (BC) inhibition.
[Biotechnology and Applied Biochemistry] |
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| Investigators described a normal breast explant model utilizing a tunable hydrogel which maintained epithelial proliferation, hormone receptor expression, and residency of T cells and macrophages over seven days.
[Journal Of Mammary Gland Biology And Neoplasia] |
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| The authors provide insights into the mechanism of exosome-derived non-coding RNAs (ncRNAs) in breast cancer (BC) drug resistance, thereby suggesting new strategies for the treatment of BC.
[Discover Oncology] |
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| Two research projects on different aspects of breast cancer treatment led by Monash Biomedicine Discovery Institute researchers, Drs. Lan Nguyen and Thierry Jardé have been awarded a total of almost $1.5 milion by the National Breast Cancer Foundation.
[Monash University] |
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| June 8 – 12, 2024
St. Louis, Missouri, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | University of Miami – Miami, Florida, United States |
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