CURRENT PUBLICATIONS
LABORATORY RESEARCH
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis Researchers show that the enzyme monoacylglycerol lipase is highly expressed in aggressive human cancer cells and primary tumors, where it regulates a fatty acid network enriched in oncogenic signaling lipids that promotes migration, invasion, survival, and in vivo tumor growth. [Cell]
Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis Using a kinase-deficient cyclin D1 mouse, researchers identified two functional mammary progenitor cell populations, one of which is the target of MMTV-ErbB2. [Cancer Cell]
Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor The findings suggest that Notch4-targeted therapies will be more effective than targeting Notch1 in suppressing breast cancer recurrence, as it is initiated by breast cancer stem cells. [Cancer Res]
Heterogeneity of Gene Expression in Stromal Fibroblasts of Human Breast Carcinomas and Normal Breast Carcinoma-associated fibroblasts (CAF) support and promote tumorigenesis, whereas normal mammary fibroblasts (NF) are thought to suppress tumor progression. Little is known about the difference in gene expression between CAF and NF or the patient-to-patient variability in gene expression. [Oncogene]
Cooperative Interaction Between Retinoic Acid Receptor-Alpha and Estrogen Receptor in Breast Cancer Retinoic acid receptor-alpha is required for efficient estrogen receptor-alpha-mediated transcription and cell proliferation. [Genes Dev]
Glypican-3 Reexpression Regulates Apoptosis in Murine Adenocarcinoma Mammary Cells Modulating PI3K/Akt and p38MAPK Signaling Pathways Glypican-3 inhibits the PI3K/Akt anti-apoptotic pathway while it stimulates the p38MAPK stress-activated pathway. [Breast Cancer Res Treat]
CLINICAL RESEARCH
Phase II Trial of Primary Systemic Therapy with Doxorubicin and Docetaxel Followed by Surgery, Radiotherapy, and Adjuvant Chemotherapy with Cyclophosphamide, Methotrexate, and 5-Fluorouracil Based on Clinical and Pathologic Response in Patients with Stage IIB to III Breast Cancer : Long-Term Results from The University of Texas M. D. Anderson Cancer Center Study ID97-099 This study was performed to evaluate the outcomes of patients with locally advanced breast cancer who were treated with a multidisciplinary approach including primary systemic chemotherapy and noncross-resistant adjuvant chemotherapy. [Cancer]
A Phase 1B Dose Escalation Trial of Scutellaria barbata (BZL101) for Patients with Metastatic Breast Cancer The study concluded that the oral administration of BZL101 was safe, well tolerated, and showed promising clinical evidence of anticancer activity in this heavily pretreated population of women with metastatic breast cancer. [Breast Cancer Res Treat]
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EVENTS
27th Annual Miami Breast Cancer Conference March 3-6, 2010 Miami, United States
7th European Breast Cancer Conference March 24-27, 2010 Barcelona, Spain
ASBD’s 34th Annual Symposium April 16-17, 2010, New York City, Untied States
BIT’s 3rd Annual World Cancer Congress 2010 – Breast Cancer Conference April 25-27, 2010 Shanghai, China
IMPAKT Breast Cancer Conference May 6-8, 2010 Brussels, Belgium
Breast Cancer Research 2010 Conference May 18, 2010 London, United Kingdom
ASCO Annual Meeting June 4-8, 2010 Chicago, United States
Gordon Research Conference: Mammary Gland Biology June 6-11, 2010 Lucca (Barga), Italy
12th Milan Breast Cancer Conference June 16-18, 2010 Milan, Italy
The 21st Meeting of the European Association for Cancer Research June 26-29, 2010 Oslo, Norway
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES
Business Development Europe – Cell Therapy Products (PALL Corporation)
Research & Development Scientist – Pancreatic Cell Biology (STEMCELL Technologies)
Research & Development Scientist – Endothelial Cell Biology (STEMCELL Technologies)
Research & Development Scientist – Epithelial Cell Biology (STEMCELL Technologies)
Data Entry Assistant – Marketing (STEMCELL Technologies)
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