CURRENT PUBLICATIONS LABORATORY RESEARCH 53BP1 Inhibits Homologous Recombination in BRCA1-Deficient Cells by Blocking Resection of DNA Breaks Here, researchers show that DNA breaks in BRCA1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining factors 53BP1 and DNA ligase 4. [Cell] CARM1 Mediates the Ligand-Independent and Tamoxifen-Resistant Activation of the Estrogen Receptor Alpha by cAMP Sustained protein kinase A activity promoting a constitutive interaction may contribute to tamoxifen resistance of breast tumors. [Genes Dev] Key Roles for MED1 LxxLL Motifs in Pubertal Mammary Gland Development and Luminal-Cell Differentiation Results establish a key nuclear receptor- and cell-specific in vivo role for MED1 LxxLL motifs, through Mediator-ER(alpha) interactions, in mammary gland development. [Proc Natl Acad Sci U S A] Function-Based Gene Identification Using Enzymatically Generated Normalized shRNA Library and Massive Parallel Sequencing As a general strategy for function-based gene identification, an shRNA library containing on average 150 shRNAs per gene was enzymatically generated from normalized (reduced-redundance) human cDNA. [Proc Natl Acad Sci U S A] Retinoic Acid Mediates Regulation of Network Formation by COUP-TFII and VE-Cadherin Expression by TGF(Beta) Receptor Kinase in Breast Cancer Cells This study demonstrates that of the endothelial-related genes induced by retinoic acid (RA) treatment, only a few were affected by knockdown of VE-cadherin, ruling it out as a regulator of the RA-induced endothelial genotypic switch. [PLoS ONE] Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer Researchers review recent evidence of the involvement of epithelial-mesenchymal transition in breast cancer tumor-initiating cells, focusing on clinical studies. [J Mammary Gland Biol Neoplasia] CLINICAL RESEARCH Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation in BRCA1 or BRCA2 This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation. [J Clin Oncol] Intratumor Heterogeneity and Precision of Microarray-Based Predictors of Breast Cancer Biology and Clinical Outcome Researchers investigate the impact of intratumor heterogeneity, a largely unstudied component of variance, on the performance of several microarray-based assays in breast cancer. [J Clin Oncol] Effect of Changing Breast Cancer Incidence Rates on the Calibration of the Gail Model The Gail model combines relative risks for five breast cancer risk factors with age-specific breast cancer incidence rates and competing mortality rates to predict risk of invasive breast cancer over a given time period. Researchers evaluated the model’s calibration in two recent cohorts. [J Clin Oncol] Effect of Zoledronic Acid on Disseminated Tumour Cells in Women With Locally Advanced Breast Cancer: An Open Label, Randomised, Phase II Trial The aim of this study was to assess the effect of zoledronic acid on clearance of disseminated tumor cells from the bone marrow in women undergoing neoadjuvant chemotherapy for breast cancer. [Lancet Oncol]
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POLICY NEWS Enhancing Peer Review: Updated Processes for the Review of All Ruth L. Kirschstein National Research Service Award Fellowship Applications (NOT-OD-10-071) [National Institutes of Health, United States] NIH Will Require the Electronic Submission of Appointment Forms and Termination Notices via xTrain for Research Training, Fellowship, Education, and Career Awards Beginning January 2011 (NOT-OD-10-072) [National Institutes of Health, United States] Small Business Innovation Research Award Levels Adjusted to $150,000 (Phase I) and $1,000,000 (Phase II) (NOT-OD-10-079) [National Institutes of Health, United States] Notice of Change in Expiration Date for Program Announcement on Bioengineering Research Partnerships (PAR-07-352) (NOT-EB-10-001) [National Institutes of Health, United States] Revision of the Requirements for Constituent Materials (Docket No. FDA-2010-N-0099) [Food and Drug Administration, United States] Voting and Nonvoting Consumer Representative Members on Public Advisory Committees and Panels; Notice of Public Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States] Determination of Regulatory Review Period for Purposes of Patent Extension; LUSEDRA (Docket Nos. FDA-2009-E-0202 and FDA-2009-E-0204) [Food and Drug Administration, United States] Revision of Organization and Conforming Changes to Regulations (Docket No. FDA-2010-N-0148) [Food and Drug Administration, United States] Administrative Practices and Procedures; Good Guidance Practices; Technical Amendment (Docket No. FDA-1999-N-3539) [Food and Drug Administration, United States] 2010 Biological License Application Supplement Noteworthy Approvals [Food and Drug Administration, United States]
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EVENTS 34th Annual Symposium of the American Society of Breast Disease (ASBD) April 16-17, 2010 New York City, United States American Association for Cancer Research (AACR) 101st Annual Meeting 2010 April 17-21, 2010 Washington, DC, United States BIT’s 3rd Annual World Cancer Congress 2010 – Breast Cancer Conference April 25-27, 2010 Shanghai, China IMPAKT Breast Cancer Conference May 6-8, 2010 Brussels, Belgium Breast Cancer Research 2010 Conference May 18, 2010 London, United Kingdom American Society of Clinical Oncology (ASCO) Annual Meeting 2010 June 4-8, 2010 Chicago, United States Gordon Research Conference: Mammary Gland Biology June 6-11, 2010 Lucca (Barga), Italy 12th Milan Breast Cancer Conference June 16-18, 2010 Milan, Italy The 21st Meeting of the European Association for Cancer Research (EACR) June 26-29, 2010 Oslo, Norway United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China 15th Congress of the European Society of Surgical Oncology (ESSO) September 15-17, 2010 Bordeaux, France 35th European Society for Medical Oncology (ESMO) Congress October 8-12, 2010 Milan, Italy International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy October 18-19, 2010 West Lafayette, United States 6th National Cancer Research Institute (NCRI) Conference November 7-10, 2010 Liverpool, United Kingdom JOB OPPORTUNITIES Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News. Visit here to post your career opportunities. Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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