TOP STORY
Hormone Sensitivity of Breast Stem Cells Presents Drug Target
Researchers have discovered that breast stem cells are exquisitely sensitive to the female hormones oestrogen and progesterone, a finding that opens the way for the development of new preventions and treatments for breast cancer. [Press release from Walter and Eliza Hall Institute of Medical Research discussing online prepublication in Nature]
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CURRENT PUBLICATIONS
LABORATORY RESEARCH
Control of Mammary Stem Cell Function by Steroid Hormone Signaling
Here researchers demonstrate that mouse mammary stem cells are highly responsive to steroid hormone signaling, despite lacking the oestrogen and progesterone receptors. [Nature]
Tuning Payload Delivery in Tumour Cylindroids Using Gold Nanoparticles
Here, researchers show that gold nanoparticles carrying either fluorescein or doxorubicin molecules move and localize differently in an in vitro three-dimensional model of tumour tissue, depending on whether the nanoparticles are positively or negatively charged. [Nat Nanotechnol]
Deciphering the Transcriptional Complex Critical for RhoA Gene Expression and Cancer Metastasis
Researchers show that RhoA transcription is orchestrated by the Myc-Skp2-Miz1-p300 transcriptional complex. [Nat Cell Biol]
HOXA9 Regulates BRCA1 Expression to Modulate Human Breast Tumor Phenotype
In this study, researchers identified homeobox A9 (HOXA9) as a gene frequently downregulated in human breast cancers and tumor cell lines and noted that reduced HOXA9 transcript levels associated with tumor aggression, metastasis, and patient mortality. [J Clin Invest]
ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation Via DEF Motif-Dependent Signaling Events
Researchers demonstrate that ERK2 but not ERK1 signaling is necessary for Ras-induced epithelial-to-mesenchymal transformation. [Mol Cell]
Antagonistic Roles of Notch and p63 in Controlling Mammary Epithelial Cell Fates
Researchers show that in primary human breast epithelial cells, maintenance of basal cell characteristics depends on continued expression of the p63 isoform, (Delta)Np63, which is expressed in the basal compartment. [Cell Death Differ]
Permanently Blocked Stem Cells Derived From Breast Cancer Cell Lines
Researchers describe here the tagging of cancer stem cell-like populations from four human breast cancer cell lines with green fluorescent protein under the control of the Oct3/4 stem cell-specific promoter. [Stem Cells]
Mouse Mammary Tumor Virus-like Sequences in Human Breast Cancer
The findings extend the evidence that mouse mammary tumor virus sequences found in naturally occurring mouse mammary tumors can be found in some human breast cancers, prompting further evaluation of causal roles in these settings. [Cancer Res]
CLINICAL RESEARCH
Effect of Concomitant CYP2D6 Inhibitor Use and Tamoxifen Adherence on Breast Cancer Recurrence in Early-Stage Breast Cancer
The objectives of this study were to relate concomitant CYP2D6 inhibitor use and tamoxifen adherence to breast cancer event-free time. [J Clin Oncol]
Effect of Zoledronic Acid on Disseminated Tumour Cells in Women with Locally Advanced Breast Cancer: An Open Label, Randomised, Phase II Trial
This study supports the hypothesis that the antimetastatic effects of zoledronic acid may be through effects on disseminated tumour cells. [Lancet Oncol]
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POLICY NEWS
University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues
Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States]
National Human Genome Research Institute Names New Chief of Genome Technology Branch
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States]
Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States]
Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States]
Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States]
Clinical Investigator Status (Biologics) [Food and Drug Administration, United States]
Background on Study Results of U.S. Academic Researchers [Food and Drug Administration, United States]
Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Department of Health & Human Services, United States]
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POLICY NEWS
University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues
Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States]
National Human Genome Research Institute Names New Chief of Genome Technology Branch
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States]
Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States]
Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States]
Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States]
Clinical Investigator Status (Biologics) [Food and Drug Administration, United States]
Background on Study Results of U.S. Academic Researchers [Food and Drug Administration, United States]
Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Department of Health & Human Services, United States]
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