TOP STORY PIK3CA Mutations in In Situ and Invasive Breast Carcinomas The results suggest that mutation of PIK3CA is an early event in breast cancer that is more likely to play a role in breast tumor initiation than in invasive progression, although a potential role for exon 9 mutations in the progression of a subset of ductal carcinoma in situ cases cannot be excluded. [Cancer Res]
|
|
SCIENCE NEWS Women Who Choose Boiled Coffee Run Lower Risk of Breast Cancer Women who drink boiled coffee more than four times a day run a lower risk of developing breast cancer than women who drink coffee less than once a day. [Press release from Umea University discussing online prepublication in Cancer Causes & Control] Angiotensin Receptor Blockers Linked to Cancer Researchers have uncovered a troubling link between angiotensin-receptor blockers and cancers of the breast, prostate, and lung. [Press release from Canadian Broadcasting Corporation discussing online prepublication in Lancet Oncology]
|
|
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies (GWAS) Researchers apply single nucleotide polymorphism (SNP)-set analysis to analyze the Cancer Genetic Markers of Susceptibility breast cancer GWAS discovery-phase data. [Am J Hum Genet] The Transcription Factor REST Is Lost in Aggressive Breast Cancer Here, researchers test the hypothesis that loss of RE1 silencing transcription factor (REST) function plays a role in breast cancer. [PLoS Genet] Nuclear Alternate Estrogen Receptor GPR30 Mediates 17Beta-Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts In this report, researchers show that cancer-associated fibroblasts respond to physiologic concentrations of 17beta-estradiol by rapidly inducing extracellular signal-regulated kinase phosphorylation and immediate early gene expression, including c-fos and connective tissue growth factor, and cyclin D1. [Cancer Res] Preneoplastic Changes Persist after IGF-IR Downregulation and Tumor Regression Type I insulin-like growth factor receptor (IGF-IR)-targeting agents may be effective at regressing mammary tumors expressing IGF-IR, but these agents will not completely eradicate all tumor cells or restore the mammary stromal environment. [Oncogene] miR-661 Expression in SNAI1-Induced Epithelial to Mesenchymal Transition Contributes to Breast Cancer Cell Invasion by Targeting Nectin-1 and StarD10 Messengers The non-a priori approach revealed a nonpredicted link between SNAI1-triggered epithelial to mesenchymal transition and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome. [Oncogene] Inhibition of AP-1 by SARI Negatively Regulates Transformation Progression Mediated by CCN1 The results illustrate that SARI (suppressor of activator protein (AP)-1, regulated by interferon (IFN)) inhibits AP-1 transactivating factor binding to the cis-element of the CCN1 promoter, possibly through its interaction with c-Jun. [Oncogene] Zinc Induces Structural Reorganization of Gelatin Binding Domain from Human Fibronectin and Affects Collagen Binding Here, researchers present the 2.5-angstrom resolution crystal structure of fibronectin’s 45-kDa gelatin-binding domain, which also corresponds to the C-terminal half of the migration stimulating factor, a Fn splice variant expressed in human breast cancers. [Structure] Progesterone Reverses the Mesenchymal Phenotypes of Basal Phenotype Breast Cancer Cells Via a Membrane Progesterone Receptor Mediated Pathway The data suggest that the signaling cascade of progesterone induced mesenchymal repression is mediated through membrane progesterone receptor alpha and other caveolae bound signaling molecules namely caveolin-1, epidermal growth factor receptor, and PI3K. [Breast Cancer Res] CLINICAL RESEARCH Effect of Body Mass Index on Recurrences in Tamoxifen and Anastrozole Treated Women: An Exploratory Analysis From the ATAC Trial The results suggest that the relative efficacy of anastrozole compared to tamoxifen is greater in thin postmenopausal women and higher doses or more complete inhibitors might be more effective in overweight women, but this requires independent confirmation. [J Clin Oncol] Are Mastectomy Rates Really Increasing in the United States? In contrast to single-institution studies, this population-based analysis found a decrease in unilateral mastectomy rates from 2000 to 2006 in the United States. [J Clin Oncol] Angiotensin-Receptor Blockade and Risk of Cancer: Meta-Analysis of Randomised Controlled Trials Researchers assessed whether angiotensin-receptor blockers affect cancer occurrence with a meta-analysis of randomised controlled trials of these drugs. [Lancet Oncol]
|
|
POLICY NEWS FDA Takes Issue with Genetic Tests from 23andMe, Four Other Firms The Food and Drug Administration has put five genetic test makers on notice that they must get federal approval before marketing their products for use by consumers. [Food and Drug Administration, United States] Diseased Cells Fail to Win Approval In the latest obstacle to expanding the number of embryonic stem-cell lines eligible for US federal funding, a National Institutes of Health (NIH) committee has unanimously rejected dozens of cell lines carrying mutations for specific diseases. [National Institutes of Health, United States] NIH Researchers Explore How Healthy, Young Adults View the Role Genetics Plays in Improving Health Most healthy young adults place greater emphasis on health habits than on genetic risk factors when considering what causes common diseases, a research team from the National Human Genome Research Institute and the Henry Ford Health System in Detroit has found. [National Institutes of Health, United States] Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States] PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-Study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States] Clinical Trials for Medicines Section Updated [Medicines and Healthcare Products Regulatory Agency, United Kingdom] Advertising and Supply of Therapeutic Goods to Complementary Healthcare Professionals: Schedule 1 to the Therapeutic Goods Regulations [Therapeutic Goods Administration, Australia] Increased Transparency of the Prescription Medicine Regulatory Process [Therapeutic Goods Administration, Australia]
|
|
EVENTS The 21st Meeting of the European Association for Cancer Research (EACR) June 26-29, 2010 Oslo, Norway United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States 15th Congress of the European Society of Surgical Oncology (ESSO) September 15-17, 2010 Bordeaux, France 2010 World Cancer Congress August 18-21, 2010 Shenzhen, China 35th European Society for Medical Oncology (ESMO) Congress October 8-12, 2010 Milan, Italy International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy October 18-19, 2010 West Lafayette, United States 6th National Cancer Research Institute (NCRI) Conference November 7-10, 2010 Liverpool, United Kingdom JOB OPPORTUNITIES Senior Scientist – Magnetic Cell Separation (STEMCELL Technologies) Business Development Manager Europe – Cell Therapy Products (Pall Corporation) Sr. Product Support and Training Specialist (CardianBCT) Manager/Sr. Manager, Therapeutic Cell Solutions, Process Development (Lonza) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News. Visit here to post your career opportunities. Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
Have we missed an important article or publication in Mammary Cell News? Click here to submit! |
| |
|