Mammary Cell News Volume 2.34 | Sep 9 2010

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    Mammary Cell News 2.34 September 9, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe


    TOP STORY

    Scientists Make Major Discovery in Finding Origins of Aggressive Breast Cancer  ShareThis
    Researchers show for the first time that the most aggressive and hard-to-treat types of breast cancer are likely to arise from intermediary, or progenitor, cells. [Press release from the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research discussing online prepublication in Cell Stem Cell]

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    SCIENCE NEWS

    Gambling on Breast Scans: Monte Carlo Analysis Could Help Reduce Number of Cancers Missed by Mammography
    A mathematical tool known as a Monte Carlo analysis could help improve the way X-rays are used for mammography and reduce the number of breast cancers missed by the technique as well as avoiding false positives, according to research. [Press release from EurekAlert! discussing online prepublication in the International Journal of Low Radiation]

    Team to Study Health Effects of Botanical Estrogens
    The Botanical Research Center will draw on the expertise of a multidisciplinary team of researchers to address the many unknowns associated with use of botanical estrogens. [The University of Illinois Press Release]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    Effect of Multikinase Inhibitors on Caspase-Independent Cell Death and DNA Damage in HER2-Overexpressing Breast Cancer Cells
    Results showed that HER2 and dasatinib-sensitive tyrosine kinases act in a synergistic manner to safeguard the breast cancer cells from DNA damage. [J Natl Cancer Inst]

    MI-219-Zinc Combination: A New Paradigm in MDM2 Inhibitor-Based Therapy
    In this clinically translatable study, researchers explored the critical role of zinc on p53 reactivation by MDM2 inhibitor, MI-219, in colon and breast cancer cells. [Cell Res]

    Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity Engendered by a Kinase-Inactive Human HER2 Adenovirus-Based Vaccination Mediates Resistance to Breast Tumors
    The findings define a critical requirement for natural killer cells in vaccine-induced protection against HER2-expressing tumors. [Cancer Res]

    Estrogen and Progesterone Receptor Status Affect Genome-Wide DNA Methylation Profile in Breast Cancer
    Researchers performed a genome-wide DNA methylation profiling to evaluate whether the DNA methylation state is different in the estrogen receptor and progesterone receptor status of breast cancer. [Hum Mol Genet]

    miR-145-Dependent Targeting of Junctional Adhesion Molecule A and Modulation of Fascin Expression are Associated with Reduced Breast Cancer Cell Motility and Invasiveness
    As several predicted targets of miR-145 potentially regulate cell motility, researchers aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. [Oncogene]

    Benefits of Biomarker Selection and Clinico-Pathological Covariate Inclusion in Breast Cancer Prognostic Models
    Researchers generated prognostic models that incorporate protein-based molecular markers and clinico-pathological variables to improve survival prediction. [Breast Cancer Res]

    Phenotypic and Molecular Characterization of the Claudin-Low Intrinsic Subtype of Breast Cancer
    Here, researchers comprehensively characterize the recently identified claudin-low tumor subtype. [Breast Cancer Res]

    CLINICAL RESEARCH

    First-Line Bevacizumab Plus Taxane-Based Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: Safety and Efficacy in an Open-Label Study in 2251 Patients
    First-line bevacizumab combined with chemotherapy significantly improves efficacy versus chemotherapy alone in human epidermal growth factor receptor 2 (HER2)-negative locally recurrent or metastatic breast cancer (LR/mBC). This large, open-label study further assesses first-line bevacizumab with taxane-based chemotherapy in routine oncology practice. [Ann Oncol]

    Meta-Analysis of the Impact of Surgical Margins on Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy
    Meta-analysis of studies reporting local recurrence relative to quantified final microscopic margin status and the threshold distance for negative margins. [Eur J Cancer]

    Mammography Image Quality Optimisation: A Monte Carlo Study
    Different irradiation configurations for typical mammographic facilities were evaluated in order to establish optimal irradiation parameters for improving X-ray image quality. [Int J Low Radiation]


    INDUSTRY NEWS

    Roche Announces Operational Excellence Initiative
    Roche announced the launch of a Group-wide Operational Excellence initiative. In view of mounting pressures to curb healthcare costs – especially in the United States and Europe – together with recent developments in late-stage projects in the Roche pipeline, this initiative aims to adapt cost structures and accelerate productivity improvements Group-wide. [Hoffmann-La Roche Ltd. Press Release]


    POLICY NEWS

    NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research
    Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States]

    Obama Administration Appeals Stem Cell Injunction
    The Obama administration asked a federal judge to lift an injunction halting human embryonic stem cell research, saying it would irreparably harm research and cost more than 1,300 jobs. [The White House, United States]

    Appeals Court Stays Stem Cell Injunction
    A federal appeals court stayed, or suspended, a preliminary injunction issued 2 weeks ago that brought federal funding for human embryonic stem cell (hESC) research to a standstill. [Court of Appeals, United States]

    Medical School Leaders Express Support for Stem Cell Research in New AAMC Ad [Association of American Medical Colleges, United States]

    Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

    Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States]

    Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States]

    Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]

    Status of Applications and Awards Involving Human Embryonic Stem Cells, and Submissions of Stem Cell Lines for Eligibility Consideration (NOT-OD-10-126) [National Institutes of Health, United States]

    Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal Research (NOT-OD-10-128) [National Institutes of Health, United States]

    Clarification of Eligible Institutions for PA-10-050: Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) [National Institutes of Health, United States]

    Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-21816) [National Institutes of Health, United States]


    EVENTS (Listed by Date)

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    15th Congress of the European Society of Surgical Oncology (ESSO)
    September 15-17, 2010
    Bordeaux, France

    Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
    September 24-27, 2010
    Montpellier, France

    International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
    September 27-28, 2010
    San Francisco, United States

    Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
    October 1, 2010
    National Harbor, United States

    2010 Breast Cancer Symposium
    October 1-3, 2010
    Washington, DC, United States

    2nd International Inflammatory Breast Cancer Conference
    October 6-7, 2010
    Marseille, France

    35th European Society for Medical Oncology (ESMO) Congress
    October 8-12, 2010
    Milan, Italy

    New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
    October 12-13, 2010
    New York, United States

    International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
    October 18-19, 2010
    West Lafayette, United States

    16th World Congress of the International Society of Senology
    October 20-22, 2010
    Valencia, Spain

    The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
    October 21-22, 2010
    Washington, DC, United States

    MENA Oncology Conference
    October 22-23, 2010
    Cairo, Egypt

    UAE Cancer Congress 2010
    October 28-30, 2010
    Dubai, United Arab Emirates

    6th National Cancer Research Institute (NCRI) Conference
    November 7-10, 2010
    Liverpool, United Kingdom

    22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
    November 16-19, 2010
    Berlin, Germany

    33rd Annual San Antonio Breast Cancer Symposium
    December 8-12, 2010
    San Antonio, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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