Mammary Cell News Volume 2.39 | Oct 14 2010

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    Mammary Cell News 2.39 October 14, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Fox Chase Researchers Uncover Achilles’ Heel in Aggressive Breast Tumors  ShareThis
    In an unexpected twist, researchers find that the loss of a single protein, Nedd9, initially slows cancer formation but then makes the tumors that do arise more aggressive. The good news, though, is that the lack of Nedd9 also makes the aggressive tumors more sensitive to a class of drugs that are already used in the clinic. [Press release from the Fox Chase Cancer Center discussing online prepublication in Cancer Research]

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    SCIENCE NEWS

    Breast Density Linked to Increased Risk of Subsequent Breast Cancer
    Researchers have found that patients with a very early form of breast cancer (ductal carcinoma in situ) who have higher mammographic density may be at increased risk for subsequent breast cancer, especially in the breast opposite to the one with the initial cancer. [Press release from the American Association for Cancer Research (AACR) discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention]

    Creighton Study Offers Hope for Women with ER-Negative Breast Cancer
    Women who have estrogen receptor-negative breast cancer may have more drug-treatment options than previously thought, a study suggests. [Press release from Creighton University discussing online prepublication in Oncogene]

    Adding Cetuximab to Chemotherapy Doubles Response Rate in Hard-to-Treat Breast Cancer
    European researchers have proven for the first time that targeting the epidermal growth factor receptor can provide substantial clinical benefit for women with hard-to-treat triple-negative breast cancer. [Press release from the European Society for Medical Oncology (ESMO) discussing data presented at the 35th ESMO Congress in Milan]

    Iniparib Extends Overall Survival in Metastatic Triple-Negative Breast Cancer: Final Phase II Results
    Women with an aggressive subtype of metastatic breast cancer appear to live an average of almost five months longer when treated with iniparib plus chemotherapy, compared to chemotherapy alone, the results of a randomized Phase II trial show. [Press release from the European Society for Medical Oncology (ESMO) discussing data presented at the 35th ESMO Congress in Milan]

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    LABORATORY RESEARCH

    Filamin A Regulates Focal Adhesion Disassembly and Suppresses Breast Cancer Cell Migration and Invasion
    In this study, researchers report that actin cross-linking protein filamin A (FLNa) suppresses invasion of breast cancer cells and regulates focal adhesion turnover. [J Exp Med]

    Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics
    Researchers investigated whether prolonged continuous selection of cells for drug resistance enriches cultures for cancer stem-like cells. [J Natl Cancer Inst]

    Methionine Sulfoxide Reductase A Down-Regulation in Human Breast Cancer Cells Results in a More Aggressive Phenotype
    In the present study, researchers show that methionine sulfoxide reductase A, which is known to protect proteins from oxidation and which acts as a reactive oxygen species scavenger, is down-regulated in a number of breast cancers. [Proc Natl Acad Sci USA]

    Enhanced Genetic Instability and Dasatinib Sensitivity in Mammary Tumor Cells Lacking NEDD9
    The studies identify NEDD9 as a complex modulator of different aspects of mammary tumor growth. [Cancer Res]

    A Positive Feedback Loop of ER-Alpha36/EGFR Promotes Malignant Growth of ER-Negative Breast Cancer Cells
    In this study, researchers found that ER-Alpha36 was highly expressed in 10/12 cases of triple-negative breast cancer. [Oncogene]

    RARalpha1 Control of Mammary Gland Ductal Morphogenesis and Wnt1-Tumorigenesis
    Retinoic acid signaling pathways are disabled in human breast cancer suggesting a controlling role in normal mammary growth that might be lost in tumorigenesis. Researchers tested a single receptor isotype, RARalpha1, for its role in mouse mammary gland morphogenesis and MMTV-wnt1-induced oncogenesis. [Breast Cancer Res]

    CLINICAL RESEARCH

    Effectiveness of Tocotrienol-Rich Fraction Combined with Tamoxifen in the Management of Women with Early Breast Cancer: A Pilot Clinical Trial
    Researchers conducted a double-blinded, placebo-controlled pilot trial to test the effectiveness of adjuvant tocotrienol therapy in combination with tamoxifen for five years in women with early breast cancer. [Breast Cancer Res]

    Stability of Estrogen Receptor (ER) Status in Breast Carcinoma
    The purposes of this study were to address a persistent controversy as to whether the ER status of a primary tumor remains stable during progression to metastasis and to evaluate the influence of disease course and prior systemic therapy on ER status. [Cancer]

    INDUSTRY NEWS

    Roche Reports Positive Data for Avastin in Ovarian Cancer and T-DM1 in Breast Cancer
    Roche announced that new data released at the 35th Congress of the European Society of Medical Oncology (ESMO) congress continue to support Roche’s development programs for Avastin in ovarian cancer and T-DM1 in HER2-positive breast cancer. [F. Hoffmann-La Roche Ltd. Press Release]

    Genomic Health Announces Analysis From First European Clinical Decision Making Study of Oncotype DX(R) Breast Cancer Test Among Spanish Physicians
    Genomic Health, Inc. announced positive results from a prospective, multi-center, study that showed the Oncotype DX(R) Recurrence Score(R) result had a significant impact on treatment decisions for early-stage breast cancer patients in Spain. [Genomic Health, Inc. Press Release]

    ImmunoGen, Inc. Announces Presentation of Encouraging Clinical Data for Lorvotuzumab Mertansine at ESMO Annual Meeting
    ImmunoGen, Inc. announced the presentation of encouraging clinical data for the Company’s lorvotuzumab mertansine (IMGN901) targeted anticancer compound at the 35th European Society for Medical Oncology (ESMO) Conference. [ImmunoGen, Inc. Press Release]

    STEMSOFT Connect – A Simplified Solution to a Complex Problem
    STEMSOFT Software Inc. is pleased to announce the release of their new standard interfaces, STEMSOFT Connect(TM). [STEMSOFT Software Inc. Press Release]

    Diamonds Donate $3 Million to Fight Breast Cancer
    Breast-cancer detection in B.C. will take a giant leap forward, thanks to a $3 million donation from the Gordon and Leslie Diamond family to the Canadian Breast Cancer Foundation and B.C. Women’s Hospital. [The Vancouver Sun]



    POLICY NEWS

    NIH Announces New Program to Accelerate Research Independence
    The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States]

    NIH Launches Genotype-Tissue Expression Project
    The National Institutes of Health (NIH) announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. [National Institutes of Health, United States]

    FDA’s $25 Million Pitch for Improving Drug Regulation
    The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States]

    FDA to Push for More Investment in Science
    Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States]

    FDA Issues Regulatory Science Report
    The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States]

    Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States]

    Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States]

    National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-25176) [National Institutes of Health, United States]

    National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-25172) [National Institutes of Health, United States]



    EVENTS (Listed by Date)

    International Symposium on Breast Cancer Prevention: Nutrition, Communications and Public Policy
    October 18-19, 2010
    West Lafayette, United States

    6th Modern Drug Discovery & Development Summit (M3D)
    October 20-22, 2010
    San Francisco, United States

    16th World Congress of the Senologic International Society
    October 20-22, 2010
    Valencia, Spain

    American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference
    October 21-22, 2010
    Washington, DC, United States

    MENA Oncology Conference
    October 22-23, 2010
    Cairo, Egypt

    Frontiers in Tumour Progression
    October 24-27, 2010
    Madrid, Spain

    2nd Annual Stem Cells Asia and Regenerative Medicine Congress
    October 26-28, 2010
    Seoul, Korea

    UAE Cancer Congress 2010
    October 28-30, 2010
    Dubai, United Arab Emirates

    6th National Cancer Research Institute (NCRI) Conference
    November 7-10, 2010
    Liverpool, United Kingdom

    9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
    November 7-10, 2010
    Philadelphia, United States

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
    November 16-19, 2010
    Berlin, Germany

    33rd Annual San Antonio Breast Cancer Symposium
    December 8-12, 2010
    San Antonio, United States

    Epithelial Plasticity and Epithelial to Mesenchymal Transition
    January 21-26, 2011
    Vancouver, Canada

    Select Biosciences 5th Annual Stem Cells World Congress
    January 24-25, 2011
    San Diego, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    28th Annual Miami Breast Cancer Conference
    March 9-12, 2011
    Miami, United States

    American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
    April 2-6, 2011
    Orlando, United States

    International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
    June 15-18, 2011
    Toronto, Canada

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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