TOP STORY Fox Chase Researchers Uncover Achilles’ Heel in Aggressive Breast Tumors In an unexpected twist, researchers find that the loss of a single protein, Nedd9, initially slows cancer formation but then makes the tumors that do arise more aggressive. The good news, though, is that the lack of Nedd9 also makes the aggressive tumors more sensitive to a class of drugs that are already used in the clinic. [Press release from the Fox Chase Cancer Center discussing online prepublication in Cancer Research]
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SCIENCE NEWS Breast Density Linked to Increased Risk of Subsequent Breast Cancer Researchers have found that patients with a very early form of breast cancer (ductal carcinoma in situ) who have higher mammographic density may be at increased risk for subsequent breast cancer, especially in the breast opposite to the one with the initial cancer. [Press release from the American Association for Cancer Research (AACR) discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention] Creighton Study Offers Hope for Women with ER-Negative Breast Cancer Women who have estrogen receptor-negative breast cancer may have more drug-treatment options than previously thought, a study suggests. [Press release from Creighton University discussing online prepublication in Oncogene] Adding Cetuximab to Chemotherapy Doubles Response Rate in Hard-to-Treat Breast Cancer European researchers have proven for the first time that targeting the epidermal growth factor receptor can provide substantial clinical benefit for women with hard-to-treat triple-negative breast cancer. [Press release from the European Society for Medical Oncology (ESMO) discussing data presented at the 35th ESMO Congress in Milan] Iniparib Extends Overall Survival in Metastatic Triple-Negative Breast Cancer: Final Phase II Results Women with an aggressive subtype of metastatic breast cancer appear to live an average of almost five months longer when treated with iniparib plus chemotherapy, compared to chemotherapy alone, the results of a randomized Phase II trial show. [Press release from the European Society for Medical Oncology (ESMO) discussing data presented at the 35th ESMO Congress in Milan]
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POLICY NEWS NIH Announces New Program to Accelerate Research Independence The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States] NIH Launches Genotype-Tissue Expression Project The National Institutes of Health (NIH) announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. [National Institutes of Health, United States] FDA’s $25 Million Pitch for Improving Drug Regulation The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States] FDA to Push for More Investment in Science Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States] FDA Issues Regulatory Science Report The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States] Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States] Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States] National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-25176) [National Institutes of Health, United States] National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-25172) [National Institutes of Health, United States]
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EVENTS (Listed by Date) International Symposium on Breast Cancer Prevention: Nutrition, Communications and Public Policy October 18-19, 2010 West Lafayette, United States 6th Modern Drug Discovery & Development Summit (M3D) October 20-22, 2010 San Francisco, United States 16th World Congress of the Senologic International Society October 20-22, 2010 Valencia, Spain American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference October 21-22, 2010 Washington, DC, United States MENA Oncology Conference October 22-23, 2010 Cairo, Egypt Frontiers in Tumour Progression October 24-27, 2010 Madrid, Spain 2nd Annual Stem Cells Asia and Regenerative Medicine Congress October 26-28, 2010 Seoul, Korea UAE Cancer Congress 2010 October 28-30, 2010 Dubai, United Arab Emirates 6th National Cancer Research Institute (NCRI) Conference November 7-10, 2010 Liverpool, United Kingdom 9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research November 7-10, 2010 Philadelphia, United States The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms November 15-18, 2010 Nara, Japan 22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany 33rd Annual San Antonio Breast Cancer Symposium December 8-12, 2010 San Antonio, United States Epithelial Plasticity and Epithelial to Mesenchymal Transition January 21-26, 2011 Vancouver, Canada Select Biosciences 5th Annual Stem Cells World Congress January 24-25, 2011 San Diego, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada 28th Annual Miami Breast Cancer Conference March 9-12, 2011 Miami, United States American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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