Mammary Cell News Volume 2.41 | Oct 28 2010

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    Mammary Cell News 2.41 October 28, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Repression of Mammary Stem/Progenitor Cells by P53 is Mediated by Notch and Separable from Apoptotic Activity  ShareThis
    The results demonstrate that basal levels of p53 restrict mammary stem/progenitor cells through Notch and that the Notch pathway is a therapeutic target to prevent expansion of this vulnerable pool of cells. [Stem Cells]

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    SCIENCE NEWS

    Scientists Show TAp63 Suppresses Cancer Metastasis
    Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs. [Press release from The University of Texas MD Anderson Cancer Center discussing online prepublication in Nature]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    A Major Role of p95/611-CTF, a Carboxy-Terminal Fragment of HER2, in the Down-Modulation of the Estrogen Receptor in HER2-Positive Breast Cancers
    The results reveal a mechanism of estrogen receptor regulation mediated by human epidermal growth factor receptor 2, which suggests a new strategy to improve responses to endocrine therapy in breast cancer. [Cancer Res]

    mTOR Complex Component Rictor Interacts with PKCZeta and Regulates Cancer Cell Metastasis
    Here, researchers report that the rapamycin-insensitive mTORC2 component protein Rictor is a critical mediator of metastasis in breast cancer cells. [ Cancer Res]

    Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features
    The oncogene cyclin D1 is highly expressed in many breast cancers and, despite its proliferation-activating properties, it has been linked to a less malignant phenotype. To clarify this observation, researchers focused on two key components of malignant behavior, migration and proliferation, and observed that quiescent G0/G1 cells display an increased migratory capacity compared to cycling cells. [Am J Pathol]

    Adipocyte Derived Paracrine Mediators of Mammary Ductal Morphogenesis Controlled by Retinoic Acid Receptors
    Researchers generated a transgenic-mouse model expressing a dominant negative-RARalpha, (RARalphaG303E) under adipocytes-specific promoter to explore the paracrine role of adipocyte retinoic acid receptors (RARs) in mammary morphogenesis. [Dev Biol]

    RB-Pathway Disruption in Breast Cancer: Differential Association with Disease Subtypes, Disease-Specific Prognosis and Therapeutic Response
    Researchers investigated RB pathway deregulation in the context of both ER-positive and ER-negative disease using combined microarray datasets encompassing over 900 breast cancer patient samples. [Cell Cycle]

    Expression of ctBP Family Protein Isoforms in Breast Cancer and Their Role in Chemoresistance
    The studies support recent evidence that CtBP family proteins represent potential targets for therapeutic strategies for the treatment of cancer in general, and breast cancer in particular. [Biol Cell]

    Spontaneously Immortalised Bovine Mammary Epithelial Cells Exhibit a Distinct Gene Expression Pattern from the Breast Cancer Cells
    Here, researchers report the establishment of a spontaneously immortalised bovine mammary epithelial cell line (BME65Cs) and the changes in gene expression associated with BME65Cs cells. [BMC Cell Biol]

    CLINICAL RESEARCH

    Long-Term Survival Among Patients With Hodgkin’s Lymphoma Who Developed Breast Cancer: A Population-Based Study
    Women with Hodgkin’s lymphoma may survive a subsequent diagnosis of breast cancer, only to experience significant excesses of death from other primary cancers and cardiac disease. [J Clin Oncol]

    Phase I Study of Everolimus Plus Weekly Paclitaxel and Trastuzumab in Patients With Metastatic Breast Cancer Pretreated With Trastuzumab
    The purpose of this study was to determine the recommended dose of everolimus, a mammalian target of rapamycin inhibitor, combined with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor 2 (HER2) -overexpressing metastatic breast cancer pretreated with trastuzumab. [J Clin Oncol]

    Increased NOS2 Predicts Poor Survival in Estrogen Receptor-Negative Breast Cancer Patients
    To investigate whether nitric oxide synthase (NOS2) levels influence survival of breast cancer patients, researchers examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors. [J Clin Invest]

    Endoxifen, a New Cornerstone of Breast Cancer Therapy: Demonstration of Safety, Tolerability, and Systemic Bioavailability in Healthy Human Subjects
    This is the first study demonstrating that single oral doses of endoxifen are safe and well tolerated and have sufficient bioavailability to reach systemically effective levels in human subjects. [Clin Pharmacol Ther]

    A Protein Microarray Signature of Autoantibody Biomarkers for the Early Detection of Breast Cancer
    Cancer patients spontaneously generate autoantibodies (AAb) to tumor-derived proteins. To detect AAb, researchers have probed novel high-density custom protein microarrays (NAPPA) expressing 4,988 candidate tumor antigens with sera from patients with early stage breast cancer, and bound IgG was measured. [J Proteome Res]



    INDUSTRY NEWS

    Unique Database of Cancer – Designed to Personalize Treatment – Is Launched
    Georgetown Lombardi Comprehensive Cancer Center announces the launch of the Georgetown Database of Cancer or G-DOC. Under development for two years, G-DOC is a repository for biological information that is normally only available in scattered information libraries and tissue banks, if at all. [Georgetown University Medical Center Press Release]

    Myriad and Abbott Enter Into Cooperative Agreement
    Myriad Genetics, Inc. announced that it has signed an agreement with Abbott Laboratories, a global health care company, to conduct BRCA1 and BRCA2 mutation testing on patients to be enrolled in a Phase III multi-center, multi-national clinical study of a novel drug candidate for the treatment of metastatic breast cancer. [Myriad Genetics, Inc. Press Release]

    BioSante Pharmaceuticals Reports Positive LibiGel(R) Data Monitoring Committee Recommendation
    BioSante Pharmaceuticals, Inc. announced that the Phase III LibiGel (testosterone gel) cardiovascular and breast cancer safety study will continue without modifications and will continue to enroll new subjects as a result of the fourth unblinded review of adverse events and the first unblinded statistical analysis for sample-size determination by its independent Data Monitoring Committee (DMC). [BioSante Pharmaceuticals, Inc. Press Release]



    POLICY NEWS

    NIH Recovery Act Awards Enable Crucial Health Research Technologies
    Thanks to the Recovery Act, more health scientists now will have access to state-of-the-art devices, the National Institutes of Health announced. Through its National Center for Research Resources, NIH has awarded $300 million in shared instrumentation grants.  [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26362) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26363) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26317) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26497) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26499) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States]

    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26702) [National Institutes of Health, United States]

    National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26706) [National Institutes of Health, United States]

    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-26390) [National Institutes of Health, United States]

    Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]



    EVENTS (Listed by Date)

    Queen Mary University of London: 5th UK Cancer Stem Cell Symposium
    November 2, 2010
    London, United Kingdom

    National Cancer Research Institute (NCRI) Conference 2010
    November 7-10, 2010
    Liverpool, United Kingdom

    9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
    November 7-10, 2010
    Philadelphia, United States

    NEW Third Annual Research Experience of Stem Cells in European Society (RESCUES) Conference
    November 8-9, 2010
    Oxford, United Kingdom

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
    November 16-19, 2010
    Berlin, Germany

    5th Annual Stem Cell Meeting on the Mesa
    December 7, 2010
    La Jolla, United States

    American Association for Cancer Research (AACR) 33rd Annual San Antonio Breast Cancer Symposium
    December 8-12, 2010
    San Antonio, United States

    Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
    January 21-26, 2011
    Vancouver, Canada

    5th Annual Stem Cells and Regenerative Medicine World Congress
    January 24-25, 2011
    San Diego, United States

    Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
    February 23-25, 2011
    San Francisco, United States

    American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
    February 24-27, 2011
    San Francisco, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    28th Annual Miami Breast Cancer Conference
    March 9-12, 2011
    Miami, United States

    MENA Oncology Conference
    March 11-12, 2011
    Cairo, Egypt

    NEW United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
    March 30-April 1, 2011
    York, United Kingdom

    American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
    April 2-6, 2011
    Orlando, United States

    International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
    June 15-18, 2011
    Toronto, Canada

    4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
    June 30-July 1, 2011
    Hamburg, Germany

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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