SCIENCE NEWS
News Note: Scientists Identify Molecular Link Between BRCA1 Protein Levels and Obesity
NCI researchers have defined a possible molecular link between breast cancer risk and obesity. New study results show that a protein called C-terminal binding protein (CtBP) acts to control a gene linked to breast cancer risk in rapidly growing cells by monitoring and responding to how the cells use and store energy (metabolic state). [Press release from the National Cancer Institute discussing online prepublication in Nature Structural and Molecular Biology]
Magnetic Field Directs Nanoparticles to Tumors
To improve the tumor-specific delivery of drug to tumors, a team of investigators from the University of California, San Diego has created a system of nanoparticles-within-a-nanoparticle that can be directed to and concentrated at the site of the tumor using a magnetic field. [Press release from the National Cancer Institute discussing online prepublication in Nano Letters]
|
|
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release
Nanocapsules containing intentionally trapped magnetic nanoparticles and defined anticancer drugs have been prepared to provide a powerful magnetic vector under moderate gradient magnetic fields. In vitro as well as in vivo results indicate that these nanocapsules can be enriched near the mouse breast tumor and are effective in reducing tumor cell growth. [Nano Lett]
Nucleotide Excision Repair Deficiency Is Intrinsic in Sporadic Stage I Breast Cancer
Taken together, the data suggest that nucleotide excision repair (NER) deficiency may play an important role in the etiology of sporadic breast cancer, and that early-stage breast cancer may be intrinsically susceptible to genotoxic chemotherapeutic agents, such as cis-platinum, whose damage is remediated by NER. [Proc Natl Acad Sci USA]
Profilin1 Regulates PI(3,4)P2 and Lamellipodin Accumulation at the Leading Edge Thus Influencing Motility of MDA-MB-231 Cells
In this study, researchers show that profilin1 negatively regulates lamellipodin targeting to the leading edge in MDA-MB-231 breast cancer cells and normal cells; profilin1 depletion increases lamellipodin concentration at the lamellipodial tip (where it binds Ena/VASP), and this mediates the hypermotility. [Proc Natl Acad Sci USA]
Systematic Detection of Putative Tumor Suppressor Genes Through the Combined Use of Exome and Transcriptome Sequencing
To identify potential tumor suppressor genes, genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele specific expression. The analysis was conducted on the breast cancer cell line, HCC1954, and a lymphoblast cell line from the same individual, HCC1954BL. [Genome Biol]
Evidence for SMAD3 as a Modifier of Breast Cancer Risk in BRCA2 Mutation Carriers
Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome wide association studies. In this study, researchers evaluated 24 single nucleotide polymorphisms tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritize candidate modifier genes for association studies. [Breast Cancer Res]
Mena Deficiency Delays Tumor Progression and Decreases Metastasis in Polyoma Middle-T Transgenic Mouse Mammary Tumors
The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Here, researchers report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development. [Breast Cancer Res]
Epigenetic Control of the Basal-Like Gene Expression Profile via Interleukin-6 in Breast Cancer Cells
Researchers conclude that IL-6, whose methylation-dependent autocrine loop is triggered by the inactivation of p53, induces an epigenetic reprogramming that drives breast carcinoma cells towards a basal-like/stem cell-like gene expression profile. [Mol Cancer]
CLINICAL RESEARCH
Effect of Obesity on Prognosis After Early-Stage Breast Cancer
This study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes in relation to adjuvant treatment. [J Clin Oncol]
|
|
EVENTS (Listed by Date)
5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States
American Association for Cancer Research (AACR) 33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States
The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China
Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada
5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States
Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States
American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States
NEW Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany
American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada
28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States
MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt
NEW PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States
United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom
American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States
NEW World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom
International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada
National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States
4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES
Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)
Lab Technologist – Tissue Culture (STEMCELL Technologies)
Product Manager – Pluripotent Stem Cells (STEMCELL Technologies)
Recruit Top Talent
Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News at no cost.
Visit here to post your career opportunities.
Have we missed an important article or publication in Mammary Cell News? Click here to submit!
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
