Study Provides Molecular Rationale For Combining Targeted Agents to Treat Breast Cancer A new study provides a rationale for treating breast cancer by combining two kinds of targeted agents, one that inhibits an overactive, cancer-causing pathway in cancer cells and one that reverses changes that silence genes that normally prevent cancer. [Press release from The Ohio State University discussing online prepublication in Cancer Research]
U-M Researchers Find Indirect Path to Attack Breast Cancer Stem Cells Scientists have identified a potential new way of attacking breast cancer stem cells. Researchers found that breast cancer stem cells are regulated by mesenchymal stem cells. [Press release from the University of Michigan (U-M) discussing online prepublication in Cancer Research]
Automated Assay Detects Lymph Node Metastases after Breast Cancer An automated molecular assay that can detect metastatic breast cancer in axillary sentinel lymph nodes during surgery performs comparably to conventional postoperative histologic examination, study findings indicate. [Press release from MedWire News discussing online prepublication in Cancer]
Inducible Formation of Breast Cancer Stem Cells and Their Dynamic Equilibrium with Non-Stem Cancer Cells via IL6 Secretion Tumor heterogeneity involves a dynamic equilibrium between cancer stem cells (CSCs) and nonstem cancer cells mediated by IL6 and activation of the inflammatory feedback loop required for oncogenesis. This dynamic equilibrium provides an additional rationale for combining conventional chemotherapy with metformin, which selectively inhibits CSCs. [Proc Natl Acad Sci USA]
Epigenetic Silencing Mediated Through Activated PI3K/AKT Signaling in Breast Cancer Trimethylation of histone 3 lysine 27 is a critical epigenetic mark for the maintenance of gene silencing. Additional accumulation of DNA methylation in target loci is thought to cooperatively support this epigenetic silencing during tumorigenesis. However, molecular mechanisms underlying the complex interplay between the two marks remain to be explored. Investigators demonstrate that activation of PI3K/AKT signaling can be a trigger of this epigenetic processing at many downstream target genes. [Cancer Res]
Targeting the Akt/Mammalian Target of Rapamycin Pathway in Brca1-Deficient Cancers To further investigate the role of breast cancer susceptibility gene 1 (Brca1)/Akt in tumorigenesis, investigators analyzed Brca1/Akt expression in human breast cancer samples and found that reduced expression of Brca1 was highly correlated with increased phosphorylation of Akt. [Oncogene]
A Novel Automated Assay for the Rapid Identification of Metastatic Breast Carcinoma in Sentinel Lymph Nodes The authors prospectively evaluated the performance of a proprietary molecular testing platform using one-step nucleic acid amplification (OSNA) for the detection of metastatic carcinoma in sentinel lymph nodes in a large multicenter trial and compared the OSNA results with the results from a detailed postoperative histopathologic evaluation (reference pathology) and from intraoperative imprint cytology. [Cancer]