LABORATORY RESEARCH Keratin 6a Marks Mammary Bipotential Progenitor Cells That Can Give Rise to a Unique Tumor Model Resembling Human Normal-Like Breast Cancer By generating transgenic mice using the keratin 6a (K6a) gene promoter to express tumor virus A, scientists provide direct evidence that K6a+ cells are bipotential progenitor cells, and the first demonstration of a non-basal location for some biopotential progenitor cells. [Oncogene] CEACAM1 Creates a Pro-Angiogenic Tumor Microenvironment that Supports Tumor Vessel Maturation Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) expression in the tumor periphery determines the vascular phenotype in a tumor, whereas systemic absence of CEACAM1 interferes with the formation of an organized tumor matrix and intratumoral vessel maturation. [Oncogene] Frizzled Homolog 7 Has a Critical Role in Cell Proliferation in Triple Negative Breast Cancer Investigators used microarray analysis to perform a pathway analysis of triple negative breast cancer compared with non-triple negative breast cancer. [Oncogene] Differential Regulation of PTEN Expression by Androgen Receptor in Prostate and Breast Cancers Scientists performed in silico analysis of publicly available microarray data sets from prostate or breast carcinomas. [Oncogene] ESR1 Is Co-Expressed with Closely Adjacent Uncharacterised Genes Spanning a Breast Cancer Susceptibility Locus at 6q25.1 Researchers’ investigation of factors associated with the level of expression of ESR1 in estrogen receptor α-positive tumors has revealed unexpected associations between genes in this region and ESR1 expression that are important to consider in studies of the genetic causes of breast cancer risk. [PLoS Genet] Transducin-Like Enhancer Protein 1 Mediates Estrogen Receptor Binding and Transcriptional Activity in Breast Cancer Cells Investigators show that the human groucho protein, transducin-like enhancer protein 1, positively assists some estrogen receptor-chromatin interactions, a role that is distinct from its general role as a transcriptional repressor. [Proc Natl Acad Sci U S A] Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice In this article, preclinical data show that the combination of the Akt activation inhibitor triciribine and the farnesyltransferase inhibitor tipifarnib is more effective than single agents both in cultured cells and in vivo. [Clin Cancer Res] Cdc42-Interacting Protein 4 Is a Src Substrate That Regulates Invadopodia and Invasiveness of Breast Tumors by Promoting Transmembrane Type I Matrix Metalloprotease Endocytosis Researchers show that Cdc42-interacting protein 4 is a Src substrate that localizes to invadopodia in MDA-MB-231 breast tumor cells expressing activated Src. [J Cell Sci] CLINICAL RESEARCH Tumor Characteristics Associated with Mammographic Detection of Breast Cancer in the Ontario Breast Screening Program Scientists conducted a case-case study within the cohort of women (n = 431 480) in the Ontario Breast Screening Program who were aged 50 years and older and were screened between January 1, 1994, and December 31, 2002. [J Natl Cancer Inst] Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening Researchers proposed a statistical framework for risk prediction given an individual’s genotype profile and family history. [Am J Hum Genet] Immunohistochemical and Molecular Analyses of HER2 Status in Breast Cancers Are Highly Concordant and Complementary Approaches Investigators compared immunohistochemistry and quantitative determination of HER2 overexpression in 466 breast tumors. [Br J Cancer] Explaining the Difference in Prognosis Between Screen-Detected and Symptomatic Breast Cancers Scientists analyzed 10-year survival data in 19 411 women aged 50–64 years diagnosed with invasive breast cancer in the West Midlands region of the United Kingdom. [Br J Cancer] |