LABORATORY RESEARCH Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Using single-molecule DNA fiber analysis, scientists show that nascent replication tracts created before fork stalling with hydroxyurea are degraded in the absence of BRCA2 but are stable in wild-type cells. [Cell] Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type Using a mammary chimera model in which an irradiated host is transplanted with oncogenic Trp53 null epithelium, investigators show accelerated development of aggressive tumors whose molecular signatures were distinct from tumors arising in non-irradiated hosts. [Cancer Cell] Zoledronic Acid Blocks the Interaction between Mesenchymal Stem Cells and Breast Cancer Cells: Implications for Adjuvant Therapy of Breast Cancer Zoledronic acid might exert its antitumor activity by inhibiting mesenchymal stem cell (MSC) migration and blocking MSCs’ secretion of factors involved in breast cancer progression. [Ann Oncol] Carnitine Palmitoyltransferase 1C Promotes Cell Survival and Tumor Growth Under Conditions of Metabolic Stress Investigators report that carnitine palmitoyltransferase 1C, a brain-specific metabolic enzyme, may participate in metabolic transformation. [Genes Dev] Disruption of Bone Morphogenetic Protein Receptor 2 (BMPR2) in Mammary Tumors Promotes Metastases through Cell Autonomous and Paracrine Mediators Scientists sought to determine whether disruption of the BMPR2 would alter mammary tumor progression in mice that express the Polyoma middle T antigen. [Proc Natl Acad Sci U S A] Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10−/− Mice Researchers generated and analyzed Abcc10−/− mice to investigate the ability of Abcc10 to function as an endogenous resistance factor. [Cancer Res] A Novel Fully Human Antitumor ImmunoRNase Targeting ErbB2-Positive Tumors Anti-ErbB2 human compact antibody-RNase was characterized as an enzymatic protein, and tested for its biological actions in vitro and in vivo on ErbB2-positive tumor cells. [Br J Cancer] CLINICAL RESEARCH Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Anti-Estrogen Therapy Failure The purpose of this study is to investigate nuclear localized and tyrosine phosphorylated Stat5 as a marker of prognosis in node-negative breast cancer and as a predictor of response to anti-estrogen therapy. [J Clin Oncol Projecting Individualized Absolute Invasive Breast Cancer Risk in Asian and Pacific Islander American Women Data from 589 women with breast cancer (case patients) and 952 women without breast cancer (control subjects) in the Asian American Breast Cancer Study were used to compute relative and attributable risks based on the age at menarche, number of affected mothers, sisters, and daughters, and number of previous benign biopsies. [J Natl Cancer Inst] Prognostic Utility of HOXB13 : IL17BR and Molecular Grade Index in Early-Stage Breast Cancer Patients from the Stockholm Trial In a blinded retrospective analysis of 588 ER-positive tamoxifen-treated and untreated breast cancer patients from the randomized prospective Stockholm trial, HOXB13 : IL17BR and molecular grade index were measured using real-time RT–PCR. [Br J Cancer] A Phase II Study of the Histone Deacetylase Inhibitor Vorinostat Combined with Tamoxifen for the Treatment of Patients with Hormone Therapy-Resistant Breast Cancer Preclinically, histone deacetylases inhibitors can reverse tamoxifen/aromatase inhibitor resistance in hormone receptor-positive breast cancer. This concept was examined in a phase II combination trial with correlative end points. [Br J Cancer] An Increase in Cancer Stem Cell Population After Primary Systemic Therapy Is a Poor Prognostic Factor in Breast Cancer The aim of this study was to investigate changes in the cancer stem cell populations before and after primary systemic therapy and their prognostic role in human breast cancer. [Br J Cancer] |