Mammary Cell News Volume 3.24 | Jun 23 2011

The HOXB7 Protein Renders Breast Cancer Cells Resistant to Tamoxifen through Activation of the EGFR Pathway
In this report, scientists provided evidence that HOXB7 overexpression renders MCF-7 cells resistant to tamoxifen via cross-talk between receptor tyrosine kinases and estrogen receptor-α signaling. [Proc Natl Acad Sci U S A]

Roadmap Published for Dynamic Mapping of Estrogen Signaling in Breast Cancer
The first roadmap to mathematical modeling of a powerful basic “decision circuit” in breast cancer has been developed. [Press release from Virginia Tech discussing online prepublication in Nature Reviews Cancer]

Is Eating Soy Safe for Breast Cancer Patients and Survivors?
A breast cancer expert has conducted research that shows that soy is safe to eat for breast cancer survivors. [Dana-Farber Cancer Institute Press Release]

LABORATORY RESEARCH

Dynamic Modeling of Estrogen Signaling and Cell Fate in Breast Cancer Cells
Because the molecular logic of breast cancer circuits is difficult to comprehend by intuitive reasoning alone, researchers presented some preliminary mathematical models of the basic decision circuits in breast cancer cells that may aid the understanding of their susceptibility or resistance to endocrine therapy. [Nat Rev Cancer]

Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice During Tumor-Specific Antibody Immunotherapy
Scientists investigated the mechanism of action of a Tn antigen-specific chimeric monoclonal antibody, which binds selectively to a wide variety of carcinomas, but not to normal tissues, in both humans and mice. [Cancer Res]

β-Arrestin 1 Mediates Metastatic Growth of Breast Cancer Cells by Facilitating Hypoxia-Induced Factor-1-Dependent Vascular Endothelial Growth Factor Expression
Investigators reported that β-arrestin 1 expression regulates breast tumor colonization in nude mice and cancer cell viability during hypoxia. [Oncogene]

Adoptive Transfer of Tumor Reactive B Cells Confers Host T Cell Immunity and Tumor Regression
Researchers investigated the antitumor reactivity of adoptively transferred effector B cells and the mechanisms by which they may mediate tumor regression in a spontaneous metastases model. [Clin Cancer Res]

Global Profiling of Signaling Networks: Study of Breast Cancer Stem Cells and Potential Regulation
In the present study, investigators identified the rare population of breast cancer stem cells using flow cytometry. [Oncologist]

Combinatorial Effects of Lapatinib and Rapamycin in Triple-Negative Breast Cancer Cells
Scientists examined the combination effects of mTOR inhibition with epidermal growth factor receptor inhibition in triple negative breast cancer in vitro and in vivo. [Mol Cancer Ther]

Methyl Binding Domain Protein 2 (MBD2) Dependent Proliferation and Survival of Breast Cancer Cells
Researchers have investigated the role of MBD2 in breast cancer cell growth and tumor suppressor gene expression. [Mol Cancer Res]

CLINICAL RESEARCH

Cost-Effectiveness of Contralateral Prophylactic Mastectomy Versus Routine Surveillance in Patients with Unilateral Breast Cancer
Contralateral prophylactic mastectomy (CPM) rates in women with unilateral breast cancer are increasing despite controversy regarding survival advantage. Current scrutiny of the medical costs led researchers to evaluate the cost-effectiveness of CPM versus routine surveillance as an alternative contralateral breast cancer risk management strategy. [J Clin Oncol]

p53 Expression in Node Positive Breast Cancer Patients: Results from the Cancer and Leukemia Group B (CALGB) 9344 Trial (159905)
Investigators studied p53 protein expression, by immunohistochemistry, in a randomized clinical trial of stage II patients treated with adjuvant doxorubicin and cyclophosphamide with or without paclitaxel. [Clin Cancer Res]

Plasma Leptin Levels and Risk of Breast Cancer in Premenopausal Women
Scientists conducted a prospective case-control study nested within the Nurses’ Health Study II cohort examining the association between plasma leptin levels in premenopausal women and breast cancer risk. [Cancer Prev Res]

A Randomized 3-Week Presurgical Trial of Lapatinib Versus Placebo in HER-2 Positive Breast Cancer
Researchers conducted a placebo-controlled trial of lapatinib administered for 3 weeks between biopsy and surgery in 60 women with HER-2 positive breast cancer to assess its antiproliferative activity in hyperplastic, dysplastic and malignant tissue. [Cancer Prev Res]

Localized Fibroglandular Tissue as a Predictor of Future Tumor Location within the Breast
In 231 British women diagnosed with breast cancer after at least one negative screen during a mammographic screening trial, investigators assessed whether tumor location was related to localized mammographic density 5 years prior to diagnosis. [Cancer Epidemiol Biomarkers Prev]

Genetic Technologies Launches BREVAGen™ Breast Cancer Risk Test in US
Genetic Technologies Limited, through its North American division Phenogen Sciences Inc., has launched the new BREVAGen™ genetic test for assessing non‐familial breast cancer risk. [Genetic Technologies Limited Press Release]

Roche Speakers at Avastin Hearing Urged to Share Financial Ties
Roche Holding AG should be required to disclose any financial ties to its presenters at a hearing to consider a U.S. proposal to withdraw approval of the drug Avastin in breast cancer, regulators said. [Bloomberg Press Release]

Leaders in Fight Against Cancer Join Historic Initiative Addressing Clinical Investigator Shortage
The Damon Runyon Cancer Research Foundation announced the formation of Accelerating Cancer Cures, a historic collaboration of the biopharmaceutical industry and academia with a strong commitment to achieving key breakthroughs in cancer treatments. [Damon Runyon Cancer Research Foundation Press Release]

Groups Come Together In Opposition To Senate Bill 173
The American Congress of Obstetricians and Gynecologists District IX, The California Radiological Society, the California Medical Association, the Medical Oncology Association of Southern California and the Association of Northern California Oncologists have come together to show opposition to Senate Bill 173. [Senate, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW American Association for Cancer Research International Conference New Horizons in Cancer Research: Biology to Prevention to Therapy
December 13-16, 2011
Gurgaon, India

Visit our events page to see a complete list of events in the mammary cell community.

Chemist (STEMCELL Technologies) 

Research and Development Senior Technologist (STEMCELL Technologies)

Lab Technologist – Tissue Culture (Maternity Leave) (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Fellow (Roswell Park Cancer Institute)

Postdoctoral Fellow Position: Transcriptional/Epigenetic Gene Regulation and Breast Cancer/Stem Cell Biology (University of Cincinnati College of Medicine)

Laboratory Project Scientist (University of California, San Diego)

Senior Research Assistant (MD Anderson Cancer Center) 

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